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Publikováno v:
Pancreas. 50:756-765
Objectives This study aimed to investigate the effect and mechanism of hypoxia on pancreatic cancer (PC) cell dedifferentiation and tumorigenic potential. Methods Inhibition of hypoxia-inducible factor 1α (HIF-1α) and overexpression of Notch1 in PC
Autor:
Dwight A. Towler
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37:392-395
Every osteotropic agent has vasculotropic actions. I have yet to see this principle violated. The reason most likely lies within the intimate relationships between bone matrix biology and the arterial vasculature in vertebrate physiology.1 Prototypic
Autor:
Hans Oberleithner, Hermann Pavenstädt, Bernd Kasprzak, Verena Hofschröer, Kristina Kusche-Vihrog, Markus Missler, Eva Brand, Astrid Rohlmann, Malte Lenders, Stefan-Martin Brand, Boris Schmitz
Publikováno v:
Journal of Hypertension. 33:2455-2462
Recently, the nanomechanical properties (i.e. stiffness) of endothelial cells have been identified as crucial for appropriate endothelial function. One major determinant of endothelial stiffness is the endothelial sodium channel (EnNaC). EnNaC-depend
Autor:
Gautam Das
Publikováno v:
Current Opinion in Lipidology. 30:355-356
Autor:
Michael J. Liptay, Mark Pool, Philip Bonomi, Dawn P. Bradly, Sanjib Basu, Paolo Gattuso, Lela Buckingham
Publikováno v:
Diagnostic Molecular Pathology. 21:207-213
Purpose Non-small cell lung cancer (NSCLC) occurs most frequently in individuals older than 60 years of age. Currently, no biological indicators associated with NSCLC in younger patients (30 to 60 y) have been identified. To explore epigenetic influe
Autor:
Ke-seng Zhao, Lihua Ao, Jessica A. Yu, Rui Song, Xianzhong Meng, David A. Fullerton, Qingchun Zeng, Joseph C. Cleveland
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:2711-2720
Objective— Although biglycan (BGN) and oxidized low-density lipoprotein (oxLDL) accumulation has been observed in calcific, stenotic aortic valves, their role in the pathogenesis of calcific aortic valve disease is poorly understood. We hypothesize
Autor:
Laia Bernet, Vegué, Federico, Rojo, David, Hardisson, Alicia Córdoba, Iturriagagoitia, Maria José, Panadés, Ana, Velasco, Eugeni López, Bonet, Rafael Cano, Muñoz, Luis, Polo, L, Polo
Publikováno v:
Diagnostic Molecular Pathology. 21:69-76
In breast cancer, the number of lymph node metastases is the strongest predictor of outcome. However, histopathology may underestimate the frequency of metastasis. Here we compare automated molecular detection of cytokeratin 19 mRNA by one-step nucle
Autor:
Yu-Jen Chen, Ming Liu, Lu-Te Chuang, Chiu-Chen Huang, Kuen-Bao Chen, Hua-Che Chiang, Chia-Ling Liu, Yuan-Chiang Chung, Chih-Ping Hsu, Chin-Hui Chen
Publikováno v:
Pancreas. 41:447-454
Grape-seed procyanidins (GSPs) can inhibit cell proliferation and invasiveness in various human cancers. However, the effect of GSP on pancreatic carcinoma cells has not been investigated.Pancreatic carcinoma cell lines MIA PaCa-2 and BxPC-3 treated
Autor:
Hjalti Gudmundsson, Patrick Wright, Shane R. Cunha, Na Li, Hervé Le Marec, Mark E. Anderson, Thomas J. Hund, Seyed Hashemi, Peter J. Mohler, Richard J. Gumina, Olha M. Koval, Niels Voigt, Vincent Probst, Dobromir Dobrev, Matthias Karck, Jean-Jacques Schott, Jingdong Li, Xander H.T. Wehrens
Publikováno v:
Circulation; Vol 124
Background— Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting >2 million patients in the United States alone. Despite decades of research, surprisingly little is known regarding the molecular pathways underlying the pathogen
Autor:
Seock-Ah Im, Se Hyung Kim, Tae Min Kim, Se-Hoon Lee, Jee Hyun Kim, Yung-Jue Bang, Tae-You Kim, Do-Youn Oh, W.H. Kim, Dong Wan Kim, Youngil Koh, Dae Seog Heo, Hee Eun Lee, Sae-Won Han
Publikováno v:
Diagnostic Molecular Pathology. 20:143-147
We intended to find predictive markers in advanced gastrointestinal stromal tumor patients treated with sunitinib. Korean patients who received sunitinib after imatinib failure for advanced gastrointestinal stromal tumor were studied. Genotyping for