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Publikováno v:
The American Journal of Dermatopathology. 43:e141-e145
Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase pathway activation has recently been found to be associated with almost all Langerhans cell histiocytosis cases. In BRAF V600E mutation-positive cases, this activation is s
Autor:
Giuseppe Familiari, Qingtao Meng, Xiaobo Li, Michael Aschner, Hongbao Yang, Shenshen Wu, Michela Relucenti, Xuehao Wang, Hao Sun, Rui Chen, Chengyu Shi
Publikováno v:
Hepatology. 74:2633-2651
Background and aims Liver metastasis is a frequent occurrence in patients with colorectal cancer (CRC), with 15%-25% of CRC patients having liver metastases at the time of initial diagnosis. Specifically, some regional-stage patients with mild sympto
Autor:
Camille Laurent, Brigitte Balme, Vanessa Szablewski, Claire Mauduit, Catherine Chassagne-Clément, Pierre Sesques, Laurent Genestier, Alexandra Traverse-Glehen, Gilles Salles, Marie Donzel, Juliette Fontaine, Jean-François Emile, Emmanuel Bachy, Hervé Ghesquières, Christiane Copie-Bergman, Alexis Trecourt
Publikováno v:
American Journal of Surgical Pathology. 46:58-70
Follicular lymphoma and classic Hodgkin lymphoma can be associated in composite and/or sequential lymphomas. Common IGH and BCL2 rearrangements have already been identified between both contingents of these entities, but mutation profiles have not ye
Expression of cathepsins B and D by cancer stem cells in head and neck metastatic malignant melanoma
Autor:
Adam B Sangster, Nicholas Bockett, Erin Paterson, Swee T. Tan, Bridget Chang-McDonald, Paul F. Davis, Josie Patel
Publikováno v:
Melanoma Research. 31:426-438
We have previously demonstrated cancer stem cell (CSC) subpopulations in head and neck metastatic malignant melanoma (HNmMM), and the expression of components of the renin-angiotensin system (RAS) by these CSCs. Cathepsins B, D and G are involved in
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 29:693-699
Glypican 3 (GPC3) is a cell membrane protein and plays a dual role, as a tumor suppressor and oncogene, depending on its structure. It is known to regulate the Wnt/β-catenin signaling pathway and affect cell growth and proliferation. β-catenin play
Autor:
Natalie D Hillerson, Joseph L Maniaci, Anne M. Mills, Timothy N. J. Bullock, Erik A. Dill, Anna C. Dusenbery
Publikováno v:
American Journal of Surgical Pathology. 45:701-707
Suppression of the immune system is intimately linked to the development and progression of malignancy, and immune modulating treatment options have shown promise in a variety of tumor types, including some triple-negative breast cancers (TNBC). The
Publikováno v:
Journal of Immunotherapy. 44:22-28
Colorectal cancer (CRC) is the third most common malignancy worldwide. The novel immune checkpoint V-domain Ig suppressor of T-cell activation (VISTA) has emerged as a promising target for cancer treatment; however, the prognostic significance of its
Autor:
Andres Matoso, Woonyoung Choi, Kara Lombardo, Belkiss Murati Amador, Trinity J. Bivalacqua, Vamsi Parimi, Noah M. Hahn, Mohammad O. Hoque, David J. McConkey, Jean H. Hoffman-Censits, Max Kates
Publikováno v:
Appl Immunohistochem Mol Morphol
Immunohistochemical stains have been suggested to aid in diagnostically challenging cases of urothelial carcinoma in-situ (CIS). Although full thickness immunostaining for CK20 is supportive of CIS, a subset of CIS cases is CK20(-), the clinical sign
Publikováno v:
Anti-Cancer Drugs. 31:973-978
Tumor human epidermal growth factor receptor 2 (HER2) status is defined by either protein expression using immunohistochemistry (IHC) or gene amplification using fluorescence in situ hybridization (FISH). Approximately 20% of HER2-positive breast can
Publikováno v:
American Journal of Surgical Pathology. 44:962-969
Secretory carcinoma (SC) of the salivary glands is a low-grade carcinoma characterized by a well-defined morphology and immunohistochemical features. ETV6-NTRK3 fusions are detected in the great majority of SCs. Recently, other partners fused to ETV6