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Publikováno v:
Journal of Immunotherapy. 44:22-28
Colorectal cancer (CRC) is the third most common malignancy worldwide. The novel immune checkpoint V-domain Ig suppressor of T-cell activation (VISTA) has emerged as a promising target for cancer treatment; however, the prognostic significance of its
Autor:
Teijo Pellinen, Mikko Loukovaara, Pia Vahteristo, Ralf Bützow, Terhi Ahvenainen, Annukka Pasanen
Publikováno v:
American Journal of Surgical Pathology. 44:174-181
Programmed death-ligand 1 (PD-L1) is a biomarker that may predict the response to anti-programmed death 1/PD-L1 immunotherapy. We evaluated the expression of PD-L1 in carcinoma cells (Ca) and immune cells (ICs) across histopathologic and The Cancer G
Publikováno v:
Am J Surg Pathol
BACKGROUND: Immune checkpoint inhibition is effective in a subset of patients with advanced gastric cancer. Genomic profiling has revealed the heterogeneity of gastric adenocarcinomas, but the immune microenvironment and predictors of immunotherapy r
Publikováno v:
American Journal of Clinical Oncology. 42:507-511
BACKGROUND Consensus guidelines recommend that active surveillance (AS) be considered in the management of men with low-risk prostate cancer (LRPC). The objective was to evaluate the prevalence and predictors of an AS approach in black men (BM) diagn
Autor:
Gloria Y.F. Ho, Geoffrey C. Kabat, Wendy E. Barrington, Mimi Y. Kim, Mara Z. Vitolins, Dorothy S. Lane, Simin Liu, Xiaochen Lin, Wanda K. Nicholson, Rowan T. Chlebowski, Thomas E. Rohan, Juhua Luo, Oleg Zaslavsky
Publikováno v:
European Journal of Cancer Prevention. 27:261-268
Limited evidence suggests that hyperinsulinemia may contribute to the risk of breast, endometrial, and, possibly, ovarian cancer. The aim of this study was to assess the association of serum glucose and insulin with risk of these cancers in postmenop
Autor:
Albert C. Koong, Sonya Aggarwal, Rie von Eyben, Muthuraman Alagappan, George A. Poultsides, Daniel T. Chang, Erqi L. Pollom, Margaret M. Kozak
Publikováno v:
American Journal of Clinical Oncology. 41:242-247
To determine if pretreatment nutritional status and inflammatory markers correlate with survival in patients with locally advanced pancreatic adenocarcinoma treated with stereotactic body radiotherapy (SBRT). We retrospectively reviewed 208 patients
Autor:
Pierre Heimann, Max Schreuer, Simon Planken, Bart Neyns, Mélanie Delaunoy, Teofila Seremet, Hakim El Housni, Yanina Jansen, Véronique Del Marmol, Danielle Lienard
Publikováno v:
Melanoma Research. 28:65-70
Anti-programmed death 1 (PD-1) monoclonal antibodies improve the survival of metastatic melanoma patients. Predictive or monitoring biomarkers for response to this therapy could improve the clinical management of these patients. To date, no establish
Autor:
Jeong Il Yu, Kyung-Il Jo, Jung-Il Lee, Heerim Nam, Do-Hyun Nam, Doo-Sik Kong, Ho Jun Seol, Yeon-Lim Suh, Do Hoon Lim, Yunseon Choi
Publikováno v:
American Journal of Clinical Oncology. 41:18-23
This study was performed to determine the clinical significance of the Ki-67 labeling index (LI) for local control (LC) in patients with World Health Organization (WHO) grade II meningioma. We also tried to discern the effect of postoperative radioth
Autor:
Patrick M. Forde, Kristen A. Marrone
Publikováno v:
The Cancer Journal. 23:219-222
Advancing age remains one of the most significant risk factors for cancer development. Changes in the immune system occur with aging, and likely play a role in the increased incidence of malignancy in older patients. With the advent of immune checkpo
Autor:
Elizabeth A. Grimm, Alexander J. Lazar, Genevieve Lyons, Chandrani Chattopadhyay, Julie A. Ellerhorst, Mariana Petaccia de Macedo, Wei Lien Wang, Junna Oba, Bita Esmaeli, Denái R. Milton
Publikováno v:
Melanoma Research. 27:126-133
This exploratory study was carried out to determine the expression levels of hepatocyte growth factor (HGF), insulin-like growth factor 1, thyroid-stimulating hormone (TSH), and leptin in serum and tumor samples from patients with uveal melanoma and