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Autor:
Kaho Nomura, Yoshihiro Osawa, Hiroshi Mano, Aya Kataoka-Matsushita, Seiko Koizumi, Seiji Kushibe, Ken-ichi Takeyama, Masashi Nagao, Yoshifumi Kimira
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Active collagen oligopeptides (ACOP) are bioactive collagen-derived peptides detected by a recently-established ELISA. To facilitate studies of the function and metabolism of these products, this study aims to determine which of these peptides is rec
Autor:
Adam J. Mead, Jack Bartram, Natalina Elliott, Anindita Roy, Carryl Dryden, Christina Halsey, Siobhan Rice, Trisevgeni Crabb, Irene Roberts, Dilys Addy, Sorcha O’Byrne, Nicholas T. Crump, Nicholas Fordham, Gary Wright, Thomas Jackson, Dariusz Ladon, Thomas A. Milne, Philip Ancliff, Maria del Mar Lara Fanego, Sarah Inglott
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arises in utero: an MLL/KMT2A gene rearrangement (MLL-r). This is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f482cb0c7edcfa62aa38988a44fec1d
https://eprints.gla.ac.uk/258628/1/258628.pdf
https://eprints.gla.ac.uk/258628/1/258628.pdf
Autor:
Nuno A. M. Araújo, Hygor P. M. Melo, Joaquim M. Oliveira, André S. Nunes, Rui L. Reis, F. Raquel Maia
Publikováno v:
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-021-99390-x.
The collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in
The collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a184abec82aab9af88d072c7fa743ebd
https://hdl.handle.net/1822/74291
https://hdl.handle.net/1822/74291
Autor:
Kim Benstead, Carolien H.M. van Deurzen, C. Poncet, Lavinia P. Middleton, Elise van Leeuwen-Stok, Isabel T. Rubio, Joanna Vermeij, Oliver Bogler, Barbro Linderholm, Tammy Piper, Carolien P. Schröder, Larissa A. Korde, Carrie Cunningham, Stéphanie Peeters, Anouk Neven, John W.M. Martens, Ingrid Hedenfalk, M Nowaczyk, Fatima Cardoso, Sharon H. Giordano, Florentine Hilbers, Eric P. Winer, Peggy L. Porter, Christi J. van Asperen, Kathryn J. Ruddy, John M. S. Bartlett, Stefan Aebi, Judith Fraser, Lissandra Dal Lago, Cecilia Nilsson, Danielle Van den Weyngaert, Jane Bayani, Monika Sobol, Catherine M. Kelly, Melissa Murray, Cheryl Crozier, Aleksandra Peric
Publikováno v:
Scientia
npj Breast Cancer, 7(1):98. Nature Publishing Group
NPJ Breast Cancer, 7(1):98, 1-8. Springer International Publishing, part of Springer Nature 2019
NPJ breast cancer, 7 (1
npj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
npj Breast Cancer
npj Breast Cancer, 7(1). NATURE RESEARCH
NPJ Breast Cancer
npj Breast Cancer, 7(1):98. Nature Publishing Group
NPJ Breast Cancer, 7(1):98, 1-8. Springer International Publishing, part of Springer Nature 2019
NPJ breast cancer, 7 (1
npj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
npj Breast Cancer
npj Breast Cancer, 7(1). NATURE RESEARCH
NPJ Breast Cancer
Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Several multigene assays are increasingly used to guide clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce951cee865544bf64f1b60973864fa4
https://hdl.handle.net/11351/6955
https://hdl.handle.net/11351/6955
Publikováno v:
Repositorio Abierto de la UdL
Universitad de Lleida
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Solé, E, Ros-Freixedes, R, Tor, M, Pena, R N & Estany, J 2021, ' A sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle ', Scientific Reports, vol. 11, no. 1, 14797 . https://doi.org/10.1038/s41598-021-94235-z
Universitad de Lleida
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Solé, E, Ros-Freixedes, R, Tor, M, Pena, R N & Estany, J 2021, ' A sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle ', Scientific Reports, vol. 11, no. 1, 14797 . https://doi.org/10.1038/s41598-021-94235-z
The bulk of body fat in mammals is in the form of triacylglycerol. Diacylglycerol O-acyltransferase 2 (DGAT2) catalyses the terminal step in triacylglycerol synthesis. The proximity of DGAT2 with stearoyl-CoA desaturase (SCD) in the endoplasmic retic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7993b526c5b58c16f0dca1551ae877
https://hdl.handle.net/10459.1/71934
https://hdl.handle.net/10459.1/71934
Autor:
Melanie S. Flint, Anotida Madzvamuse, Chandrasekhar Venkataraman, Marta Falcinelli, Hazel J. Hunt, Andrew E. Greenstein, Eduard Campillo-Funollet, Haya Intabli, Myrthe Mampay, Gheed Abdulmajeed Waleed Al-Hity, Feng Wei Yang
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Investigational in vitro models that reflect the complexity of the interaction between the immune system and tumours are limited and difficult to establish. Herein, we present a platform to study the tumour-immune interaction using a co-culture betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260f1f7b7463c44fcf4ea9fdc19f576d
http://sro.sussex.ac.uk/id/eprint/101167/1/s42003-021-02296-7.pdf
http://sro.sussex.ac.uk/id/eprint/101167/1/s42003-021-02296-7.pdf
Autor:
Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith
Publikováno v:
Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fa596497393cd588028cd95531690
https://hdl.handle.net/1887/3213877
https://hdl.handle.net/1887/3213877
Autor:
Ingebjørg Seljeflot, Johannes R. Hov, Vemund Paulsen, Asta Bye, Geir E. Tjønnfjord, Kristin Aneta Joan Skaarud, Knut E.A. Lundin, Per Ole Iversen, Marius Trøseid, Simen Hyll Hansen, Jørgen Valeur, Martin Kummen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Gut mucosal barrier injury is common following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and associated with poor clinical outcomes. Diet is critical for microbial diversity, but whether nutritional support affects microbiota and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9aededd52d88a0545b6897bb299640
https://hdl.handle.net/11250/2761177
https://hdl.handle.net/11250/2761177
Autor:
George Dickson, Linda Popplewell, Farhat V N Din, Adam E. Hall, Kevin Myant, Malcolm G. Dunlop, Paz Freile, Alfonso Bolado, Caroline V. Billard, Victoria Gudiño, Stuart Aitken, Mark Agostino, David A. Stevenson, Douglas Strathdee, Laura Murphy, Owen J. Sansom, Alex von Kriegsheim, Sebastian Öther-Gee Pohl, John W. Cassidy, Patrizia Cammareri, Colin Nixon, Ann P. Wheeler
Publikováno v:
Nature Communications
Gudiño, V, Öther-Gee Pohl, S, V Billard, C, Cammareri, P, Bolado Carrancio, A, Aitken, S, Stevenson, D, Hall, A, Agostino, M, Cassidy, J, Nixon, C, von Kriegsheim, A, Friele, P, Popplewell, L, Dickson, G, Murphy, L, Wheeler, A P, Dunlop, M G, Din, F V N, Strathdee, D, J. Sansom, O & Myant, K B 2021, ' Rac1b modulates intestinal tumourigenesis via modulation of Wnt and Egfr signalling pathways ', Nature Communications . https://doi.org/10.1038/s41467-021-22531-3
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Gudiño, V, Öther-Gee Pohl, S, V Billard, C, Cammareri, P, Bolado Carrancio, A, Aitken, S, Stevenson, D, Hall, A, Agostino, M, Cassidy, J, Nixon, C, von Kriegsheim, A, Friele, P, Popplewell, L, Dickson, G, Murphy, L, Wheeler, A P, Dunlop, M G, Din, F V N, Strathdee, D, J. Sansom, O & Myant, K B 2021, ' Rac1b modulates intestinal tumourigenesis via modulation of Wnt and Egfr signalling pathways ', Nature Communications . https://doi.org/10.1038/s41467-021-22531-3
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Current therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during treatment is common, even following patient stratification. Understanding the mechanisms that promote therapy resistance may lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d761f8e664c9c0e74b157a8fb7baff43
https://eprints.gla.ac.uk/239120/1/239120.pdf
https://eprints.gla.ac.uk/239120/1/239120.pdf
Autor:
Llueca, Antoni, Climent Martí, María Teresa, Escrig-Sos, Javier, Carrasco, Paula, Serra Rubert, Anna, Gómez-Quiles, Luis, Játiva, R., Cebrian, G., Boso, Virginia, Villarin, A., Maiocchi, Karina, Delgado Barriga, Katty, RODRIGO-ALIAGA, MIGUEL, Ruiz, N., Herrero, C., Frances, A., Beato, I., Ferrer, C., Kessler, Juan Pablo Aracil, Boldo Roda, Enrique, Boldo, A., Adell, R.
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
SCIENTIFIC REPORTS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Scientific Reports
Universitat Jaume I
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
SCIENTIFIC REPORTS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Scientific Reports
The standard treatment for advanced ovarian cancer (AOC) is cytoreduction surgery and adjuvant chemotherapy. Tumor volume after surgery is a major prognostic factor for these patients. The ability to perform complete cytoreduction depends on the exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327b6a4f8c31bfd3a2e69a31615c63d