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pro vyhledávání: '"Patrick T. Ellinor"'
Autor:
Anthony A. Philippakis, Julian R. Homburger, Patrick T. Ellinor, Amit Khera, Eric S. Lander, Sekar Kathiresan, Alexander G. Bick, Matthew S. Lebo, Deanna Brockman, Kenney Ng, Akl C. Fahed, Cynthia L. Neben, Minxian Wang, Aniruddh P. Patel, Christopher A. Cassa, Carmen Lai, Alicia Y. Zhou
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Genetic variation can predispose to disease both through (i) monogenic risk variants that disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that involves many variants of small effect in different pathways. Few studie