Zobrazeno 1 - 10
of 10 374
pro vyhledávání: '"0301 basic medicine"'
Autor:
Lili Gao, Yi Sui, Wei Hu, Tao Yang, Dejian Li, Rujian Zhu, Hongbo Zhu, Qingtong Yi, Qinghua You, Wei Zhang, Tao Tang, Shengjuan Zhu
Publikováno v:
British Journal of Cancer
Background Metastasis is the major cause of treatment failure and cancer-related deaths in prostate cancer (PCa) patients. Our previous study demonstrated that a CD44+ subpopulation isolated from PCa cells or tumours possesses both stem cell properti
Autor:
Wenkai Zhu, Yunxian Dong, Pu Cheng, Yue Yan, Changlin Zhang, Jiayuan Zhu, Wuguo Deng, Bing Tang, Shaobin Huang, Xiaoling Cao, Miao Chen, Peng Wang, Dingbo Shi, Zhicheng Hu, Chuanbo Xie, Hailin Xu
Publikováno v:
Oncogene
We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the treatment of melanoma because of acquired r
Publikováno v:
British Journal of Cancer
Although low risk localised prostate cancer has an excellent prognosis owing to effective treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic prostate cancer remains incurable. Existing therapeutic regimens prolong lif
Autor:
Joanne Edwards, Somaieh Hedayat, Claudio Murgia, Owen J. Sansom, Gabriela Kramer-Marek, Luciano Cascione, Elisa Fontana, Pierluigi Gasparini, Jens C. Hahne, Carlo M. Croce, Matteo Fassan, Carlos D. Martins, Andrea Lampis, Paul G. Horgan, Georgios Vlachogiannis, L. Terracciano, Chiara Braconi, Nicola Valeri
Publikováno v:
Cell Death and Differentiation
Junctional adhesion molecules (JAMs) play a critical role in cell permeability, polarity and migration. JAM-A, a key protein of the JAM family, is altered in a number of conditions including cancer; however, consequences of JAM-A dysregulation on car
Publikováno v:
British Journal of Cancer
Colorectal cancer represents the second leading cause of cancer-related death worldwide. The therapeutic field of immuno-oncology has rapidly gained momentum, with strikingly promising results observed in clinical practice. Increasing emphasis has be
Autor:
Umberto Vitolo, Alessandra Rossi, Pier Luigi Zinzani, Claudio Agostinelli, Pier Giuseppe Pelicci, Saveria Mazzara, Giovanna Motta, Valentina Tabanelli, Federica Melle, Myriam Alcalay, Corrado Tarella, Francesco Bertolini, Paolo Falvo, Stefano Fiori, Beatrice Casadei, Elena Baiardi, Stefano Pileri, Stefania Orecchioni, Enrico Derenzini, Angelica Calleri, Chiara Corsini
Publikováno v:
Leukemia
Standard chemotherapies for diffuse large B-cell lymphoma (DLBCL), based on the induction of exogenous DNA damage and oxidative stress, are often less effective in the presence of increased MYC and BCL-2 levels, especially in the case of double hit (
Autor:
Youquan Bu, Tao Liu, Xiaoyan Fan, Chunxue Zhang, Yunlong Lei, Yuelei Jin, Zhongyu Liu, Yitao Wang, Yulong Niu, Kailong Du, Tinghui Jiang
Publikováno v:
Oncogene
B-Myb is an important transcription factor that plays a critical role in gene expression regulation and tumorigenesis. However, its functional implication in colorectal cancer remains elusive. In this study, we found that B-Myb was significantly upre
Autor:
Stefan J. Marciniak, David Fairen-Jimenez, Xiewen Liu, Robert C. Rintoul, Marie Shamseddin, Marko Nikolic, Arsalan A. Azad, Joanna Obacz, Emily Linnane, Doris Rassl, Henry Yung
Publikováno v:
British Journal of Cancer
Funder: British Lung Foundation (BLF); doi: https://doi.org/10.13039/501100000351
Funder: Royal Society through a University Research Fellowship and the Engineering and Physical Sciences Research Council (EPRSC)
Funder: China Scholarship Co
Funder: Royal Society through a University Research Fellowship and the Engineering and Physical Sciences Research Council (EPRSC)
Funder: China Scholarship Co
Publikováno v:
International Journal of Obesity (2005)
Omnivores, including rodents and humans, compose their diets from a wide variety of potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to sweet and avoidance of bitter, they have limited innate dietary knowledge
Autor:
R Smith, Emily K. O’Neill
Publikováno v:
Eye
Visual disturbance or visual failure due to toxicity of an ingested substance or a severe nutritional deficiency can present significant challenges for diagnosis and management, for instance, where an adverse reaction to a prescribed medicine is susp