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Autor:
Si Wang, Xiaohong Yao, Shuai Ma, Yifang Ping, Yanling Fan, Shuhui Sun, Zhicheng He, Yu Shi, Liang Sun, Shiqi Xiao, Moshi Song, Jun Cai, Jiaming Li, Rui Tang, Liyun Zhao, Chaofu Wang, Qiaoran Wang, Lei Zhao, Huifang Hu, Xindong Liu, Guoqiang Sun, Lu Chen, Guoqing Pan, Huaiyong Chen, Qingrui Li, Peipei Zhang, Yuanyuan Xu, Huyi Feng, Guo-Guang Zhao, Tianzi Wen, Yungui Yang, Xuequan Huang, Wei Li, Zhenhua Liu, Hongmei Wang, Haibo Wu, Baoyang Hu, Yong Ren, Qi Zhou, Jing Qu, Weiqi Zhang, Guang-Hui Liu, Xiu-Wu Bian
Publikováno v:
Nature Cell Biology
The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19)-related mortality. However, our cellular and molecular understanding of h
Autor:
Daniel C. Levine, Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G. Wright, Meredith A. Sommars, Yumiko Kobayashi, Biliana Marcheva, Peng Gao, Olga R. Ilkayeva, Chiaki Omura, Kathryn M. Ramsey, Christopher B. Newgard, Grant D. Barish, Clara Bien Peek, Navdeep S. Chandel, Milan Mrksich, Joseph Bass
Publikováno v:
Nature Metabolism
In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. Although NAD+ also p
Autor:
Yaoqin Gong, Limei Xu, Qiao Liu, Tingting Yang, Jing Wang, Xiyu Zhang, Guosheng Lv, Wenqing Bu, Changshun Shao, Xiaojie Liu, Dong Hou, Xiaohe Hao
Publikováno v:
Oncogene
Reactive oxygen species (ROS) serve as critical signals in various cellular processes. Excessive ROS cause cell death or senescence and mediates the therapeutic effect of many cancer drugs. Recent studies showed that ROS increasingly accumulate durin
Autor:
Ayesha A. Shafi, Peter T. Gallagher, Renée de Leeuw, Jennifer J. McCann, Emanuela Dylgjeri, Christopher McNair, Neermala Poudel Neupane, Amy C. Mandigo, Matthew J. Schiewer, Irina A. Vasilevskaya, Karen E. Knudsen
Publikováno v:
Oncogene
The tumor suppressor gene TP53 is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Specifically, missense mutations in TP53 are selectively enriched in PCa, and cluster to particular “hot spots” in the p
Autor:
Zhang Hai, Jiao Wu, Yu-Meng Zhu, Jie-Jie Geng, Ping Zhu, Qi-Jing Li, Zhi-Nan Chen, Ruo Chen, Peng Lin, Ke Wang, Fengfan Yang, Xianghui Fu, Zhuan Feng
Publikováno v:
Cellular and Molecular Immunology
Regulatory T cell (Treg) stability is necessary for the proper control of immune activity and tissue homeostasis. However, it remains unclear whether Treg stability must be continually reinforced or is established during development under physiologic
Publikováno v:
Cellular and Molecular Immunology
The COVID pandemic has refreshed and expanded recognition of the vital role that sustained antibody (Ab) secretion plays in our immune defenses against microbes and of the importance of vaccines that elicit Ab protection against infection. With this
Publikováno v:
Oncogene
Induced waves of calcium fluxes initiate multiple signalling pathways that play an important role in the differentiation and maturation of B-cells. Finely tuned transient Ca+2fluxes from the endoplasmic reticulum in response to B-cell receptor (BCR)
Autor:
Tae Min Kim, Hyung Wook Kim, Hae Jin Cho, Jong Young Lee, Sun Ah Nam, Jin Won Kim, Yong Kyun Kim
Publikováno v:
Experimental & Molecular Medicine
Fabry disease is an X-linked lysosomal storage disease caused by a mutation in the galactosidase alpha (GLA) gene. Despite advances in therapeutic technologies, the lack of humanized experimental models of Fabry disease has limited the development of
Autor:
Daisuke Okuzaki, Mamoru Uemura, Takashi Takeda, Yuichiro Doki, Hidekazu Takahashi, Norikatsu Miyoshi, Masaki Mori, Hiroaki Itakura, Hodaka Fujii, Toshitsugu Fujita, Hiroo Ueno, Hidetoshi Eguchi, Shogo Kobayashi, Kaho Asai, Hirofumi Yamamoto, Yuhki Yokoyama
Publikováno v:
British Journal of Cancer
Background KLF5 plays a crucial role in stem cells of colorectum in cooperation with Lgr5 gene. In this study, we aimed to explicate a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cance
Autor:
Jia Zhe Su, Michael H. Malim, Daniel Cox, Neophytos Kouphou, Sam Acors, Carl Graham, Ana Maria Ortega-Prieto, Luke B Snell, Cassandra Fairhead, Stuart J. D. Neil, Liane Dupont, Helena Winstone, Thomas Lechmere, Rui Pedro Galão, Sadie R. Hallett, Gaia Nebbia, Isabella Huettner, Nathalia Almeida, Marie Jose Lista, Adela Alcolea-Medina, Thomas J. A. Maguire, Suzanne Pickering, Manu Shankar-Hari, Rahul Batra, Jonathan D. Edgeworth, Jose M. Jimenez-Guardeño, Katie J. Doores, Ruth E Dickenson, Jeffrey Seow, Themoula Charalampous, Harry Wilson, Blair Merrick
Publikováno v:
Nature Microbiology
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses of convalescent sera provi