Zobrazeno 71 - 80
of 1 798
pro vyhledávání: ''
Autor:
Adam Southon, Sophia J Luikinga, Andre L. Samson, Aida Viden, James M. Murphy, Brittany Cuic, Samantha K. Barton, Nirma D Perera, Doris Tomas, Catriona McLean, Taide Wang, Bradley J. Turner, Ashley I. Bush
Publikováno v:
Cell Death Differ
Amyotrophic lateral sclerosis (ALS) is caused by selective degeneration of motor neurons in the brain and spinal cord; however, the primary cell death pathway(s) mediating motor neuron demise remain elusive. We recently established that necroptosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808298cfc4ea679a0fadfc715a2d9cf2
https://europepmc.org/articles/PMC9177596/
https://europepmc.org/articles/PMC9177596/
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2021)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2021)
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal hematologic malignancy for which novel therapeutic targets and strategies are required. Emerging evidence suggests that WTIP is a candidate tumor suppressor. However, the molecula
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2021)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2021)
Background Colorectal cancer (CRC) remains the most common gastrointestinal cancer and a leading cause of cancer deaths worldwide, with most showing pathologies indicating the malignant transformation of early stage intestinal stem cells. The long no
Autor:
Marek J Noga, Johan F. A. Pijnenborg, Nienke Eerden, Jona Merx, Thomas J. Boltje, Emiel Rossing, Raisa Veizaj, Willem H C Titulaer, Dirk Lefeber, Paul B. White
Publikováno v:
Nature Communications
Nature Communications, 12, 1, pp. 1-9
Nature Communications, 12, 1-9
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, 12, 1, pp. 1-9
Nature Communications, 12, 1-9
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The sugar fucose is expressed on mammalian cell membranes as part of glycoconjugates and mediates essential physiological processes. The aberrant expression of fucosylated glycans has been linked to pathologies such as cancer, inflammation, infection
Autor:
Shu-Ping Wang, Shi-Qi Wu, Shi-Hui Huang, Yi-Xuan Tang, Liu-Qiong Meng, Feng Liu, Qi-Hua Zhu, Yun-Gen Xu
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Inducing homologous-recombination (HR) deficiency is an effective strategy to broaden the indications of PARP inhibitors in the treatment of triple-negative breast cancer (TNBC). Herein, we find that repression of the oncogenic transcription factor F
Autor:
Xiaofan Feng, Tianyi Jiang, Chun Yang, Shujie Pang, Zhiwen Ding, Heping Hu, Hui Wang, Liwei Dong, Ning Yang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2021)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2021)
NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles and oxidation, promotes NRF2 degradation in unstressed conditions. SQSTM1/p62, an oncogenic protein ab
Autor:
Ulrike Schoetz, Diana Klein, Julia Hess, Seyd Shnayien, Steffen Spoerl, Michael Orth, Samet Mutlu, Roman Hennel, Anja Sieber, Ute Ganswindt, Benedikt Luka, Andreas R. Thomsen, Kristian Unger, Verena Jendrossek, Horst Zitzelsberger, Nils Blüthgen, Claus Belka, Steffen Unkel, Bertram Klinger, Kirsten Lauber
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death Dis. 12:1162 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death Dis. 12:1162 (2021)
Resistance against radio(chemo)therapy-induced cell death is a major determinant of oncological treatment failure and remains a perpetual clinical challenge. The underlying mechanisms are manifold and demand for comprehensive, cancer entity- and subt
Autor:
Sandra Fernández-Martos, María I. Calvo-Sánchez, Ana Lobo-Aldezabal, Ana Isabel Sánchez-Adrada, Carmen Moreno, María Vitale, Jesús Espada
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
The homeostatic and regenerative potential of the skin is critically impaired by an increasing accumulation of air pollutants in human ecosystems. These toxic compounds are frequently implicated in pathological processes such as premature cutaneous a
Autor:
Hee Jeong Cho, Sung-Hoon Jung, Jae-Cheol Jo, Yoo Jin Lee, Sang Eun Yoon, Sung-Soo Park, Do Young Kim, Ho-Jin Shin, Yeung-Chul Mun, Jun Ho Yi, Hyo Jung Kim, Da Jung Kim, Ho Sup Lee, Sung Hwa Bae, Chae Moon Hong, Shin Young Jeong, Jung-Joon Min, Sang Kyun Sohn, Chang-Ki Min, Kihyun Kim, Je-Jung Lee, Joon Ho Moon, The Korean Multiple Myeloma Working Party
Publikováno v:
Blood Cancer Journal
Blood Cancer Journal, Vol 11, Iss 12, Pp 1-8 (2021)
Blood Cancer Journal, Vol 11, Iss 12, Pp 1-8 (2021)
Background A high number of focal lesions (FL) detected using PET/CT at diagnosis were found to be associated with adverse prognosis along with Revised International Staging System (R-ISS). In present study, we combined R-ISS with FL using PET/CT to
Autor:
Fangfang Zhao, Chunbao Zang, Fengmei Chao, Hui Deng, Youguang Pu, Ran Xia, Minghua Xie, Lingsuo Kong, Yiao Tan, Fangfang Ge, Shanbao Cai, Dabing Huang, Yueyin Pan, Cifeng Cai
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-15 (2021)
Long-noncoding RNAs (lncRNAs) play roles in regulating cellular functions. High-throughput sequencing analysis identified a new lncRNA, termed LAMTOR5-AS1, the expression of which was much higher in the chemosensitive osteosarcoma (OS) cell line G-29