Zobrazeno 61 - 70
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Autor:
Chen Wang, Haoyu Wu, Yuanming Xing, Yulan Ye, Fangzhou He, Qian Yin, Yujin Li, Fenqing Shang, John Y.-J. Shyy, Zu-Yi Yuan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Endothelial dysfunction and vascular smooth muscle cell (VSMC) plasticity are critically involved in the pathogenesis of hypertension and arterial stiffness. MicroRNAs can mediate the cellular communication between vascular endothelial cells (ECs) an
Autor:
Yuqing Li, Weijian Chen, Kazumi Ogawa, Masashi Koide, Tadahisa Takahashi, Yoshihiro Hagiwara, Eiji Itoi, Toshimi Aizawa, Masahiro Tsuchiya, Rumiko Izumi, Naoki Suzuki, Masashi Aoki, Makoto Kanzaki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Contractile activity is a fundamental property of skeletal muscles. We describe the establishment of a “feeder-supported in vitro exercise model” using human-origin primary satellite cells, allowing highly-developed contractile myotubes to readil
Autor:
Wen-jin Chen, Hao Cao, Jian-wei Cao, Li Zuo, Fa-jun Qu, Da Xu, Hao Zhang, Hai-yi Gong, Jia-xin Chen, Jian-qing Ye, Si-shun Gan, Wang Zhou, Da-wei Zhu, Xiu-Wu Pan, Xin-gang Cui
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment paradigms for different subtypes. To reveal
Autor:
Jianling Bi, Yuping Zhang, Paige K. Malmrose, Haley A. Losh, Andreea M. Newtson, Eric J. Devor, Kristina W. Thiel, Kimberly K. Leslie
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Histone deacetylase (HDAC) inhibitors and proteasome inhibitors have been approved by the FDA for the treatment of multiple myeloma and lymphoma, respectively, but have not achieved similar activity as single agents in solid tumors. Preclinical studi
Autor:
You Zhou, Qi Wang, Haifeng Deng, Bin Xu, Yi Zhou, Jian Liu, Yingting Liu, Yufang Shi, Xiao Zheng, Jingting Jiang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Gastric cancer (GC) is the fifth most common tumor and the third most deadly cancer worldwide. N6-methyladenosine (m6A) modification has been reported to play a regulatory role in human cancers. However, the exact role of m6A in GC remains largely un
Autor:
Chong Zhang, Xiang-Yu Wang, Peng Zhang, Tao-Chen He, Jia-Hao Han, Rui Zhang, Jing Lin, Jie Fan, Lu Lu, Wen-Wei Zhu, Hu-Liang Jia, Ju-Bo Zhang, Jin-Hong Chen
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Tumor metastasis is a hallmark of cancer. The communication between cancer-derived exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche formation and cancer metastasis. However, the mechanisms underlying exoso
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-1 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-1 (2022)
Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in mul
Autor:
Xunhua Liu, Jianxiong Chen, Xiaoli Long, Jiawen Lan, Xiaoting Liu, Miao Zhou, Sijing Zhang, Jun Zhou
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
RSL1D1 (ribosomal L1 domain containing 1), a member of the universal ribosomal protein uL1 family, was suggested to be a new candidate target for colorectal cancer (CRC). However, the role of RSL1D1 in cancer, including CRC, remains largely elusive.
Autor:
Gang Wang, Yanan Wang, Qinzhi Yang, Chunrong Xu, Youkun Zheng, Liqun Wang, Jianbo Wu, Min Zeng, Mao Luo
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
Methylglyoxal (MGO) is an active metabolite of glucose and plays a prominent role in the pathogenesis of diabetic vascular complications, including endothelial cell apoptosis induced by oxidative stress. Metformin (MET), a widely prescribed antidiabe
Autor:
Ana Muñiz-García, Montserrat Romero, Juan Manuel Falcόn-Perez, Patricia Murray, Antonio Zorzano, Silvia Mora
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Dipòsit Digital de la UB
Universidad de Barcelona
Extracellular vesicles (EVs) are membrane enclosures released by eukaryotic cells that carry bioactive molecules and serve to modulate biological responses in recipient cells. Both increased EV release and altered EV composition are associated with t