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Autor:
Yaoqin Gong, Limei Xu, Qiao Liu, Tingting Yang, Jing Wang, Xiyu Zhang, Guosheng Lv, Wenqing Bu, Changshun Shao, Xiaojie Liu, Dong Hou, Xiaohe Hao
Publikováno v:
Oncogene
Reactive oxygen species (ROS) serve as critical signals in various cellular processes. Excessive ROS cause cell death or senescence and mediates the therapeutic effect of many cancer drugs. Recent studies showed that ROS increasingly accumulate durin
Autor:
Siqi Gao, Pucheng Mei, Yongming Wang, Baocai Gao, Feiyan Xie, Chen Ding, Jixi Li, Jiasong Pan, Xiangjun Chen, Jiaxue Wu, Wenqing Gao, Sen Wang, Rui Ge
Publikováno v:
Cell Death and Differentiation
Receptor interacting protein kinase 3 (RIP3 or RIPK3), the critical executor of cell programmed necrosis, plays essential roles in maintaining immune responses and appropriate tissue homeostasis. Although the E3 ligases CHIP and PELI1 are reported to
Autor:
Tao Yan, Zongming Song, Xi Yang, Wencan Wu, Xin Ju, Jia Qu, Shilong Ying, Beibei Wu, Huaicheng Chen, Zong-Duan Zhang, Yi Wang
Publikováno v:
Experimental & Molecular Medicine
Modified LDL-induced inflammation and oxidative stress are involved in the pathogenesis of diabetic retinopathy. Recent studies have also shown that modified LDL activates Toll-like receptor 4 (TLR4) to mediate retinal injury. However, the mechanism
Autor:
Stefan Schulte-Merker, Sasja Blokzijl-Franke, Philippe Herbomel, Jeroen den Hertog, Karima Kissa, Bas Ponsioen, Suma Choorapoikayil
Publikováno v:
Oncogene
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial
Autor:
Amy Li, Daniel Martinez, Busra Turgu, Luigi Tortola, Christopher S. Hughes, Fan Zhang, Tony Ng, Poul H. Sorensen, Melanie Kogler, Fraser Johnson, Josef M. Penninger, John M. Maris, William W. Lockwood, Amal El-Naggar, Gian Luca Negri, Donald T. T. Yapp, Mads Daugaard
Publikováno v:
Oncogene
Oncogene, 40 (11)
Oncogene, 40 (11)
Uncovering the mechanisms that underpin how tumor cells adapt to microenvironmental stress is essential to better understand cancer progression. The HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase) gene is a tumor suppres
Autor:
Ye Zhao, Rui Zhou, Kunyu Yang, Tao Zhang, William Pat Fong, Xiaorong Dong, Xiaohua Jie, Yingchao Zhao, Gang Wu, Shuangbing Xu, Sheng Zhang, Rui Meng
Publikováno v:
Cell Death and Differentiation
Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer. However, the underlying mechanisms of radioresistance remain elusive. Here, we show that lysine-specific demethylase 4C (KDM4C) is overexpressed and correlated
Autor:
Marco Haselager, Rachel Thijssen, Arnon P. Kater, Christopher West, Roel J. W. van Kampen, Elaine Willmore, Simon P. Mackay, Eric Eldering, Louise C. Young
Publikováno v:
Cell Death and Differentiation
Cell death and differentiation, 28(5), 1658-1668. Nature Publishing Group
Cell death and differentiation, 28(5), 1658-1668. Nature Publishing Group
In chronic lymphocytic leukemia (CLL), the lymph node (LN) microenvironment delivers critical survival signals by inducing the expression of anti-apoptotic Bcl-2 members Bcl-XL, Bfl-1, and Mcl-1, resulting in apoptosis blockade. We determined previou
Publikováno v:
Cell Death and Differentiation
Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline. Despite millions of people being affected worl
Publikováno v:
Cell Death and Differentiation
Despite recent advances in our understanding of the disease, glioblastoma (GB) continues to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify this heterogeneous malignancy using molecular classifiers iden
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1705-1714 (2020)
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1705-1714 (2020)
DNA end resection has a key role in double-strand break repair and DNA replication. Defective DNA end resection can cause malfunctions in DNA repair and replication, leading to greater genomic instability. DNA end resection is initiated by MRN-CtIP g