Zobrazeno 1 - 10
of 28
pro vyhledávání: ''
Autor:
Wenhao Jiang, Lian Huang, Yunqiang Liu, Yilu Lu, Dachang Tao, Yue Song, Xu Zhao, Bojun Qiu, Yongxin Ma
Publikováno v:
Cell Death and Differentiation
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies and cause of death from cancer in China. Previous studies showed that autophagy and apoptosis inhibition are critical for the survival of ESCC cells. However, the underl
Autor:
Angus W. Jackson, Rita Moreno, Albena T. Dinkova-Kostova, Sourav Banerjee, Jean A. Quinn, Jack E. Dixon, Joanne Edwards, Gregg Baillie, Laureano de la Vega
Publikováno v:
Cell Death and Differentiation
To survive proteotoxic stress, cancer cells activate the proteotoxic-stress response pathway, which is controlled by the transcription factor heat shock factor 1 (HSF1). This pathway supports cancer initiation, cancer progression and chemoresistance
Autor:
Tadashi Matsuda, Daisuke Motooka, Ryuta Muromoto, Naoki Hosen, Akira Tanimura, Daisuke Okuzaki, Yuichi Kitai, Jun-ichi Kashiwakura, Hirohiko Shibayama, Takafumi Yokota, Kenji Oritani, Jun Toda, Yuzuru Kanakura, Michiko Ichii, Hideaki Saito
Publikováno v:
Oncogene
The family of signal-transducing adapter proteins (STAPs) has been reported to be involved in a variety of intracellular signaling pathways and implicated as transcriptional factors. We previously cloned STAP-2 as a c-Fms interacting protein and expl
Autor:
Seung Ri Lee, Jaewhan Song, Young Jin, Jin-Ho Seo, Peter Vandenabeele, Young Woo Nam, Han Woong Lee, Choong Sil Lee, Doo Byoung Oh, Daehyeon Seong, Chi Hyun Hwang
Publikováno v:
Cell Death and Differentiation
CELL DEATH AND DIFFERENTIATION
CELL DEATH AND DIFFERENTIATION
Necroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood. Here, we identified that Bec
Autor:
Paulina Roux-Biejat, Sara Barozzi, Emilio Clementi, Claudia Moscheni, Cristiana Perrotta, Michela Ripolone, Marco Coazzoli, Chiara Vantaggiato, Massimiliano Garrè, Matteo Giovarelli, Dario Parazzoli, Emanuele Martini, Silvia Zecchini, Davide Cervia, Clara De Palma, Laura Napoli
Publikováno v:
Cell Death and Differentiation
Mitochondria change distribution across cells following a variety of pathophysiological stimuli. The mechanisms presiding over this redistribution are yet undefined. In a murine model overexpressing Drp1 specifically in skeletal muscle, we find marke
Autor:
Guenter K. Stalla, Wolfgang Saeger, Ulrich Renner, Anne Barlier, Yonghe Wu, Marily Theodoropoulou, Michael Buchfelder, Jose Monteserin Garcia, Kristin Lucia
Publikováno v:
Oncogene
Overactivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inhe
Autor:
Wei Zhao, Zongli Zhang, Yunfei Xu, Jianhua Chang, Xingyong Li, Sen Guo, Anda Shi, Tao Zhou, Yue Wang, Xiao-Qing Yang, Wentao Mu, Zengli Liu, Kangshuai Li, Guangli Ren, Bowen Xu, Jialiang Liu, Tianli Chen, Chang Pan
Publikováno v:
Cell Death Differ
Cholangiocarcinoma (CCA), consisting of three subtypes-intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA), is a highly aggressive cancer arising from the bile duct and has an extremely poor prognosis. Pemigatinib is the only FDA-approved target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaa0d07067caafc2f378aed46f9adaa
https://europepmc.org/articles/PMC8990017/
https://europepmc.org/articles/PMC8990017/
Autor:
Anja Zeigerer, Susanne Ullrich, Felicia Gerst, Andreas Fritsche, M Julia Scerbo, Nils O’Brien, Robert Wagner, Hans-Ulrich Häring, Anett Seelig, Jantje M. Gerdes, Francesco Volta
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Diabetes mellitus affects one in eleven adults worldwide. Most suffer from Type 2 Diabetes which features elevated blood glucose levels and an inability to adequately secrete or respond to insulin. Insulin producing β-cells have primary cilia which
Autor:
Georgialina Rodriguez, Yoshira M. Ayala-Marin, Amy J. Arrieta, Alice H. Grant, Alejandro Rodriguez, Armando X. Estrada, Robert A. Kirken
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
T-cell activation and cellular expansion by common gamma chain cytokines such as Interleukin-2 is necessary for adaptive immunity. However, when unregulated these same pathways promote pathologies ranging from autoimmune disorders to cancer. While th
Autor:
Zhiwei Liu, Jian Zhang, Lulu Pan, Shengjie Liao, Wei Dai, Xiaomin Wang, Lei Zhao, Linhui Zhai, Duan Ni, Ping Liu, Xiaoji Cong, Wei Liu, Xing-Long Jia, Yulu Chen, Jing Ji, Minjia Tan, Bin Liu, Min Huang
Publikováno v:
Cell Death Differ
SKP1-CUL1-F-box (SCF) ubiquitin ligases play fundamental roles in cellular functions. Typically, substrate phosphorylation is required for SCF recognition and subsequent degradation. However, phospho-dependent substrates remain largely unidentified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f31dfb2ba631323ea03e7cef62d179
https://europepmc.org/articles/PMC8738747/
https://europepmc.org/articles/PMC8738747/