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pro vyhledávání: ''
Autor:
Nanna Skeltved, Mads Daugaard, Maj Sofie Ørum-Madsen, Thomas Mandel Clausen, Mie A. Nordmaj, Swati Choudhary, Zhang Yang, Robert Dagil, Kaare V. Grunddal, Emilie S. Sachse, Thor G. Theander, Weihua Tian, Ali Salanti, Morten Nielsen, Igor Moskalev, Sayit Mahmut Erdoğan, Morgan E. Roberts, Anne Poder Andersen, Tobias Gustsavsson
Publikováno v:
Cell Death & Disease
Nordmaj, M A, Roberts, M E, Sachse, E S, Dagil, R, Andersen, A P, Skeltved, N, Grunddal, K V, Erdoğan, S M, Choudhary, S, Gustavsson, T, Ørum-madsen, M S, Moskalev, I, Tian, W, Yang, Z, Clausen, T M, Theander, T G, Daugaard, M, Nielsen, M A & Salanti, A 2021, ' Development of a bispecific immune engager using a recombinant malaria protein ', Cell Death & Disease, vol. 12, no. 4, 353 . https://doi.org/10.1038/s41419-021-03611-0
Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
Nordmaj, M A, Roberts, M E, Sachse, E S, Dagil, R, Andersen, A P, Skeltved, N, Grunddal, K V, Erdoğan, S M, Choudhary, S, Gustavsson, T, Ørum-madsen, M S, Moskalev, I, Tian, W, Yang, Z, Clausen, T M, Theander, T G, Daugaard, M, Nielsen, M A & Salanti, A 2021, ' Development of a bispecific immune engager using a recombinant malaria protein ', Cell Death & Disease, vol. 12, no. 4, 353 . https://doi.org/10.1038/s41419-021-03611-0
Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
As an immune evasion and survival strategy, the Plasmodium falciparum malaria parasite has evolved a protein named VAR2CSA. This protein mediates sequestration of infected red blood cells in the placenta through the interaction with a unique carbohyd
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Osteoporosis is the most prevailing primary bone disease and a growing health care burden. The aim of this study was to clarify the functional roles and mechanisms of the circ-ITCH regulating osteogenic differentiation of osteoporosis. Circ-ITCH and
Autor:
Lintao Zhong, Yuhua Hu, Yulin Liao, Zhongyu Wen, Gaojun Zhong, Weiling Lu, Gonghua Hu, Haoyu Song, Shiju Zhou, Shan Zeng, Yiming Zhong, Rongming Ding, Yu Zhou, Lianglliang Lyu, Yalan Wang, Jiahe Xie, Dongming Xie, Qin Liao, Qingrui Li
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the formation of abdominal aortic aneurysms (AAAs). FoxO3a is a key suppressor of VSMC homeostasis. We found that in human and animal AAA tissues, FoxO3a was upregulated
Autor:
Kayoung Shin, Harim Koo, Jason K. Sa, Seok Chung, Do-Hyun Nam, Se Jeong Lee, Yeri Lee, Hye mi Shin, Seung Won Choi, Donggeon Kim, Hyunho Kim, Hee Jin Cho, Jihye Shin, Cheolju Lee
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
PTEN is one of the most frequently altered tumor suppressor genes in malignant tumors. The dominant-negative effect of PTEN alteration suggests that the aberrant function of PTEN mutation might be more disastrous than deletion, the most frequent geno
Autor:
Tao Jiang, Jinbo Zhao, Qiang Lu, Yanlu Xiong, Tianyun Qiao, Jie Lei, Yongsheng Zhou, Lin-Tao Jia, Yong Han, Yangbo Feng
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-13 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-13 (2021)
Transcription factor AP-2α (TFAP2A) was previously regarded as a critical regulator during embryonic development, and its mediation in carcinogenesis has received intensive attention recently. However, its role in lung adenocarcinoma (LUAD) has not
Autor:
Guo-qiu Xu, Ben-Tong Yu, Hui Yin, Jian-Hua Zha, Yonghua Sang, Ying-Chen Xia, Jie Zhen, Yan Zhang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Activation of adenosine monophosphate-activated protein kinase (AMPK) is able to produce significant anti-non-small cell lung cancer (NSCLC) cell activity. ASP4132 is an orally active and highly effective AMPK activator. The current study tested its
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-17 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-17 (2021)
Autophagy defection contributes to inflammation dysregulation, which plays an important role in gastric cancer (GC) progression. Various studies have demonstrated that long noncoding RNA could function as novel regulators of autophagy. Previously, lo
Autor:
Patricia Jauregui, Celia Sequera, Óscar Herranz, Ignacio Rubio, Carmen Guerrero, Alvaro Gutierrez-Uzquiza, Maria Rodrigo-Faus, Almudena Porras, Paloma Bragado, Stephanie Morgner, Sara Manzano
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-17 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
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Cell Death and Disease, Vol 12, Iss 4, Pp 1-17 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
© The Author(s) 2021.
Glioblastoma (GBM) is the most aggressive tumor from the central nervous system (CNS). The current lack of efficient therapies makes essential to find new treatment strategies. C3G, a guanine nucleotide exchange factor for
Glioblastoma (GBM) is the most aggressive tumor from the central nervous system (CNS). The current lack of efficient therapies makes essential to find new treatment strategies. C3G, a guanine nucleotide exchange factor for
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-10 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-10 (2021)
The innate and adaptive immune cells have complex signaling pathways for sensing and initiating immune responses against disease. These pathways are interrupted at different levels to occur immune evasion, including by N6-methyladenosine (m6A) modifi
Autor:
Zixiang Wang, Haiyang Guo, Beihua Kong, Xiyu Zhang, Ling Zhao, Jianping Song, Junchao Qin, Zhaojian Liu, Shourong Wang, Changshun Shao, Yingwei Li, Jieyin Li
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Aberrant expression of splicing factors was found to promote tumorigenesis and the development of human malignant tumors. Nevertheless, the underlying mechanisms and functional relevance remain elusive. We here show that USP39, a component of the spl