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Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-1 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-1 (2022)
Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in mul
Autor:
Ana Muñiz-García, Montserrat Romero, Juan Manuel Falcόn-Perez, Patricia Murray, Antonio Zorzano, Silvia Mora
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Dipòsit Digital de la UB
Universidad de Barcelona
Extracellular vesicles (EVs) are membrane enclosures released by eukaryotic cells that carry bioactive molecules and serve to modulate biological responses in recipient cells. Both increased EV release and altered EV composition are associated with t
Autor:
Adrian Salic, Wanqiu Li, Wenchen Liu, Sisi Li, Feitong Dong, Bradley M. Wierbowski, Peiyi Wang, Mo Lu, Linlin Wang, Xin Gong
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The membrane protein Dispatched (Disp), which belongs to the RND family of small molecule transporters, is essential for Hedgehog (Hh) signaling, by catalyzing the extracellular release of palmitate- and cholesterol-modified Hh ligands from producing
Autor:
Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M.M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W.E. Santen, Marco Trizzino
Publikováno v:
Nature Communications
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subunit switches in the BAF chromatin remodeler are essential during development. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause neurodevelopmental disorders, including Coffi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
CD81 is an integral membrane protein of the tetraspanin family and forms complexes with a variety of other cell surface membrane proteins. CD81 is involved in cell migration and B cell activation. However, the mechanism of the transcriptional regulat
Publikováno v:
Oncogene
Ouyang, H, Luong, P, Frödin, M & Hansen, S H 2020, ' p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth ', Oncogene, vol. 39, no. 33, pp. 5570-5587 . https://doi.org/10.1038/s41388-020-1385-2
Ouyang, H, Luong, P, Frödin, M & Hansen, S H 2020, ' p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth ', Oncogene, vol. 39, no. 33, pp. 5570-5587 . https://doi.org/10.1038/s41388-020-1385-2
The ARHGAP35 gene encoding p190A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human cancer, but the functional implications of such alterations are not known. Here, we demonstrate for the first time that p190A is a
Autor:
Robb E. Moses, Xiaotao Li, Rifeng Gao, Wenlong Yang, Junbo Ge, Aijun Sun, Yifan Xie, Zheng Dong, Yang Gao
Publikováno v:
Cell Death and Differentiation
Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner.
Autor:
Seung Ri Lee, Jaewhan Song, Young Jin, Jin-Ho Seo, Peter Vandenabeele, Young Woo Nam, Han Woong Lee, Choong Sil Lee, Doo Byoung Oh, Daehyeon Seong, Chi Hyun Hwang
Publikováno v:
Cell Death and Differentiation
CELL DEATH AND DIFFERENTIATION
CELL DEATH AND DIFFERENTIATION
Necroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood. Here, we identified that Bec
Autor:
Karla P. Figueroa, Mandi Gandelman, Daniel R. Scoles, Warunee Dansithong, Sharan Paul, Stefan M. Pulst
Publikováno v:
Cell Death and Differentiation
Cell Death Differ
Cell Death Differ
Staufen-1 (STAU1) is an RNA-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule-associated protein tau (MAPT), huntingtin (HTT), TAR DNA
Autor:
Hua Yu, Jun Ding, Yao Jing, Hongwen Zhu, Heng-Li Tian, Gang Wang, Hu Zhou, Xiongjun Wang, Ke Tang
Publikováno v:
Cell Death and Differentiation
The lysyl oxidase (LOX) family is closely related to the progression of glioma. To ensure the clinical significance of LOX family in glioma, The Cancer Genome Atlas (TCGA) database was mined and the analysis indicated that higher LOXL1 expression was