Zobrazeno 51 - 60
of 240
pro vyhledávání: ''
Autor:
Wei Zhou, Yang Qiu, Jingfang Mu, Xue Yi Zhang, Yujie Ren, Di Wu, Chong Wang, Muhan Huang, Yang Han, Ting Shu, Xi Zhou
Publikováno v:
Cellular and Molecular Immunology
Cellular & Molecular Immunology
Cellular & Molecular Immunology
Autor:
Jacquelyn Serfecz, Lucia Notterpek, Peter C. Turner, Hannah Bazick, Christopher J. Fields, Pedro E. Cruz, Rolf Renne, Mohammed Omar Al Salihi
Publikováno v:
Gene Therapy
The majority of hereditary neuropathies are caused by duplication of the peripheral myelin protein 22 (PMP22) gene. Therefore, mechanisms to suppress the expression of the PMP22 gene have high therapeutic significance. Here we asked whether the human
Autor:
James K. Fields, Eric J. Sundberg, Xuexiang Du, Yang Liu, Pan Zheng, Chunxia Ai, Fei Tang, Martin Devenport, Olga Latinovic, Mingyue Liu, Peng Zhang, Yan Zhang
Publikováno v:
Cell Research
Cell Res
Cell Res
It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while
Publikováno v:
Cellular and Molecular Immunology
Evidence supports a possible role of BANK1 in innate immune signaling in B cells. In the present study, we investigated the interaction of BANK1 with two key mediators in interferon and inflammatory cytokine production, TRAF6 and MyD88. We revealed b
Autor:
Yanfeng Wu, Su’an Tang, Jinteng Li, Huiyong Shen, Zhongyu Xie, Mengjun Ma, Peng Wang, Guan Zheng, Hongjun Su, Wenjie Liu, Shan Wang, Guiwen Ye, Xiaohua Wu, Shuizhong Cen, Ming Li
Publikováno v:
Cell Death and Differentiation
TNF receptor-associated factor 4 (TRAF4), a member of the TRAF family, plays an important role in the embryogenesis and development of the bone system. Mesenchymal stem cells (MSCs), which are the primary origin of osteoblasts in vivo, are key cells
Autor:
Xu Li, Edward V. Prochownik, Yi Tang, Kaisa Cui, Yajun Li, Qiang Zhang, Xingrong Lin, Youjun Li
Publikováno v:
Cell Death Differ
The ubiquitin-proteasome system regulates many distinct biological processes. Its dysregulation causes various diseases, including but not limited to cancer. In this study, based on the analysis of gene expression in several colorectal cancer (CRC) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625209f63d1bc7c96281c07a0e61463d
https://europepmc.org/articles/PMC8257708/
https://europepmc.org/articles/PMC8257708/
Autor:
Wenqi Zhang, Lei Jiang, Xiaohui Xu, Wenjing Sun, Lifang Luo, Yi-Hu Zheng, Daoquan Fang, Weijian Zhu, Tan Hooi Min Grahn, Shuhan Li
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021)
Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021)
Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and cervical cancer, but its therapeutic benefit is limited by the development of resistance. Our previo
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 2, Pp 1-3 (2021)
Cell Death and Disease, Vol 12, Iss 2, Pp 1-3 (2021)
Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase-
Autor:
Lu Wang, Jonathan Himmelfarb, Patrick L. Iversen, Andrew J. Annalora, Edward J. Kelly, Theo K. Bammler, Marija Jozic, Maria Beatriz Monteiro, Kevin A. Lidberg, Susanne Ramm, Craig B. Marcus, Daniel S. Elson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hy
Autor:
Weida Gong, Stephanie D. Byrum, Phillip M. Galbo, Jie Li, Ling Cai, Alan J. Tackett, Aaron J. Storey, Samuel G. Mackintosh, Xufen Yu, Yi-Hsuan Tsai, Jeong Hyun Ahn, Shenghui He, Yiran Guo, Jian Jin, Ricky D. Edmondson, Jason E. Farrar, Deyou Zheng, Gang Greg Wang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM conf