Zobrazeno 1 - 10
of 413
pro vyhledávání: ''
Autor:
Jia Zhe Su, Michael H. Malim, Daniel Cox, Neophytos Kouphou, Sam Acors, Carl Graham, Ana Maria Ortega-Prieto, Luke B Snell, Cassandra Fairhead, Stuart J. D. Neil, Liane Dupont, Helena Winstone, Thomas Lechmere, Rui Pedro Galão, Sadie R. Hallett, Gaia Nebbia, Isabella Huettner, Nathalia Almeida, Marie Jose Lista, Adela Alcolea-Medina, Thomas J. A. Maguire, Suzanne Pickering, Manu Shankar-Hari, Rahul Batra, Jonathan D. Edgeworth, Jose M. Jimenez-Guardeño, Katie J. Doores, Ruth E Dickenson, Jeffrey Seow, Themoula Charalampous, Harry Wilson, Blair Merrick
Publikováno v:
Nature Microbiology
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses of convalescent sera provi
Autor:
Yanqing Ding, Chuan-Sha Gu, Xiao-Yan Wang, Yan Zhong, Jing-Yi Tang, Ling-Fang Gao, Yi-Dan Ma, Zhi-Yan Hu, Xia Wang, Zu-Guo Li, Jia-Xian Zhu, Ting Long
Publikováno v:
Cell Death and Differentiation
Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours that can predict the risk of CRC metastasis is now urgently needed. In this study, we identified aut
Autor:
Qixiang Li, Xiangwei Zeng, Jian Cao, Xinyu Li, Yexuan Deng, Dongjun Yang, Haiqin Jiang, Dake Li, Peipei Xu, Bing Chen, Ying Wang, Quan Zhao, Tao Gui, Ming Liu, David C.S. Huang, Bing Yao, Guiping Wan, Liqin Zhou, Zhihui Wang, Ke Zen
Publikováno v:
Cell Death and Differentiation
Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, the molecular mechanisms underlying EC progression are still largely unknown, and chemotherapeutic options for EC patients are currently very limited. In this stu
Autor:
Aine Knott, Chengcheng Meng, Abigail E Case, Prafulla C. Gokhale, Alex E. Pozhitkov, Ruben D. Carrasco, Yin P Hung, Moshe Lapidot, James D. Griffin, Sunil Sharma, Martin Sattler, Raphael Bueno, Klaus Podar, David A. Frank, Sarah R. Walker, Srinivas Vinod Saladi, Swati Garg, Ellen Weisberg, Ravi Salgia, Prakash Kulkarni, Wei Ni
Publikováno v:
British Journal of Cancer
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A
Autor:
Xu Han, Wenjing Pang, Xiaoyu Luo, Lidan Hou, Yu Liang, Qing-Wei Zhang, Ping Wang, Xiangjun Meng, Yichao Hou, Lei Li, Xin-Tian Zhang
Publikováno v:
Cell Death and Differentiation
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a malnourished environment; however, little is known about the mechanisms by which PDAC cells actively promote aerobic glycolysis to maintain their metabol
Autor:
Stefan Schulte-Merker, Sasja Blokzijl-Franke, Philippe Herbomel, Jeroen den Hertog, Karima Kissa, Bas Ponsioen, Suma Choorapoikayil
Publikováno v:
Oncogene
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial
Autor:
Xinhui Lan, Simeng Wang, Chao Feng, Haihong Zhang, Qingqing Gu, Meiju Ji, Liang Shi, Yuelei Zhao, Xi Su, Peng Hou, Wei Qiang
Publikováno v:
Cell Death and Differentiation
Small nucleolar RNA SNORD50A and SNORD50B (SNORD50A/B) has been reported to be recurrently deleted and function as a putative tumor suppressor in different types of cancer by binding to and suppressing the activity of the KRAS oncoproteins. Its delet
Autor:
Linguo Xu, Lin Huan, Xianghuo He, Qifeng Wang, Shenglin Huang, Yangjun Wu, Tianan Guo, Yanfang Liu, Ye Xu, Linhui Liang
Publikováno v:
Oncogene
Epigenetic alteration is one of the hallmarks of colorectal cancer (CRC). Many driver genes are regulated by DNA methylation in CRC. However, the role of DNA methylation regulating lncRNAs remain elusive. Here, we identify that SNHG11 (small nucleola
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1310-1325 (2020)
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1310-1325 (2020)
Our study aimed to determine how lncRNA DANCR, miR-320a, and CTNNB1 interact with each other and regulate osteogenic differentiation in osteoporosis. qRT-PCR and western blotting were performed to determine the expression of DANCR, miR-320a, CTNNB1,
Autor:
Zhifang Guo, Limin Yang, Wei Chong, Xiaoli Liu, Ming Zhang, Feng Gu, Yongjie Ma, Yawen Zhao, Caixia Guo, Huikun Zhang, Zhe Wang, Li Fu, Ying Shao
Publikováno v:
Cell Death and Differentiation
Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce breast cancer mortality by 20–30%. Furthermore, there is no appropriate biom