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Autor:
Srdjan Djurovic, Evgeniia Frei, Ole A. Andreassen, Jordi Requena Osete, Olav B. Smeland, Nils Eiel Steen, Denis Reis de Assis, Timothy P. Hughes, Attila Szabo, Ibrahim Akkouh
Publikováno v:
Molecular Psychiatry
Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely understood. Here we invest
Publikováno v:
Molecular Psychiatry
Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with th
Autor:
Rosella Abeti, Michele Frison, Dong Xia, Kenneth Smith, Lisa Wells, Daniela Strobbe, Federico Turkheimer, Danilo Faccenda, Paola Giunti, Marija Sajic, Manuel Rigon, Michelangelo Campanella, Katy Barnes, Heather Mortiboys, Mona Sadeghian, Britannie S. England-Rendon, Diana Cash
Publikováno v:
Molecular Psychiatry
Dysfunctional mitochondria characterise Parkinson’s Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to pathological cues, is therefore pivotal to inform early diagnosis and therapy in the condi
Autor:
Jingyi Wang, Qian Zhong, Hua Zhang, Shangxin Liu, Shibing Li, Tianliang Xia, Zhiwen Xiao, Renhui Chen, Yuchu Ye, Faya Liang, Ping Han, Xiaoming Huang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Distant metastasis remains the major cause for treatment failure in patients with nasopharyngeal carcinoma (NPC). Thus, it is necessary to investigate the underlying regulation mechanisms and potential biomarkers for NPC metastasis. Nogo-B (neurite o
Autor:
Wen-jin Chen, Hao Cao, Jian-wei Cao, Li Zuo, Fa-jun Qu, Da Xu, Hao Zhang, Hai-yi Gong, Jia-xin Chen, Jian-qing Ye, Si-shun Gan, Wang Zhou, Da-wei Zhu, Xiu-Wu Pan, Xin-gang Cui
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment paradigms for different subtypes. To reveal
Autor:
Jianling Bi, Yuping Zhang, Paige K. Malmrose, Haley A. Losh, Andreea M. Newtson, Eric J. Devor, Kristina W. Thiel, Kimberly K. Leslie
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Histone deacetylase (HDAC) inhibitors and proteasome inhibitors have been approved by the FDA for the treatment of multiple myeloma and lymphoma, respectively, but have not achieved similar activity as single agents in solid tumors. Preclinical studi
Autor:
You Zhou, Qi Wang, Haifeng Deng, Bin Xu, Yi Zhou, Jian Liu, Yingting Liu, Yufang Shi, Xiao Zheng, Jingting Jiang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Gastric cancer (GC) is the fifth most common tumor and the third most deadly cancer worldwide. N6-methyladenosine (m6A) modification has been reported to play a regulatory role in human cancers. However, the exact role of m6A in GC remains largely un
Autor:
Chong Zhang, Xiang-Yu Wang, Peng Zhang, Tao-Chen He, Jia-Hao Han, Rui Zhang, Jing Lin, Jie Fan, Lu Lu, Wen-Wei Zhu, Hu-Liang Jia, Ju-Bo Zhang, Jin-Hong Chen
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Tumor metastasis is a hallmark of cancer. The communication between cancer-derived exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche formation and cancer metastasis. However, the mechanisms underlying exoso
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-1 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-1 (2022)
Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in mul
Autor:
Xunhua Liu, Jianxiong Chen, Xiaoli Long, Jiawen Lan, Xiaoting Liu, Miao Zhou, Sijing Zhang, Jun Zhou
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
RSL1D1 (ribosomal L1 domain containing 1), a member of the universal ribosomal protein uL1 family, was suggested to be a new candidate target for colorectal cancer (CRC). However, the role of RSL1D1 in cancer, including CRC, remains largely elusive.