Zobrazeno 1 - 10
of 477
pro vyhledávání: ''
Autor:
Zhang Hai, Jiao Wu, Yu-Meng Zhu, Jie-Jie Geng, Ping Zhu, Qi-Jing Li, Zhi-Nan Chen, Ruo Chen, Peng Lin, Ke Wang, Fengfan Yang, Xianghui Fu, Zhuan Feng
Publikováno v:
Cellular and Molecular Immunology
Regulatory T cell (Treg) stability is necessary for the proper control of immune activity and tissue homeostasis. However, it remains unclear whether Treg stability must be continually reinforced or is established during development under physiologic
Autor:
Jia Zhe Su, Michael H. Malim, Daniel Cox, Neophytos Kouphou, Sam Acors, Carl Graham, Ana Maria Ortega-Prieto, Luke B Snell, Cassandra Fairhead, Stuart J. D. Neil, Liane Dupont, Helena Winstone, Thomas Lechmere, Rui Pedro Galão, Sadie R. Hallett, Gaia Nebbia, Isabella Huettner, Nathalia Almeida, Marie Jose Lista, Adela Alcolea-Medina, Thomas J. A. Maguire, Suzanne Pickering, Manu Shankar-Hari, Rahul Batra, Jonathan D. Edgeworth, Jose M. Jimenez-Guardeño, Katie J. Doores, Ruth E Dickenson, Jeffrey Seow, Themoula Charalampous, Harry Wilson, Blair Merrick
Publikováno v:
Nature Microbiology
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses of convalescent sera provi
Autor:
Wenkai Zhu, Yunxian Dong, Pu Cheng, Yue Yan, Changlin Zhang, Jiayuan Zhu, Wuguo Deng, Bing Tang, Shaobin Huang, Xiaoling Cao, Miao Chen, Peng Wang, Dingbo Shi, Zhicheng Hu, Chuanbo Xie, Hailin Xu
Publikováno v:
Oncogene
We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the treatment of melanoma because of acquired r
Autor:
Yanqing Ding, Chuan-Sha Gu, Xiao-Yan Wang, Yan Zhong, Jing-Yi Tang, Ling-Fang Gao, Yi-Dan Ma, Zhi-Yan Hu, Xia Wang, Zu-Guo Li, Jia-Xian Zhu, Ting Long
Publikováno v:
Cell Death and Differentiation
Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours that can predict the risk of CRC metastasis is now urgently needed. In this study, we identified aut
Autor:
Aine Knott, Chengcheng Meng, Abigail E Case, Prafulla C. Gokhale, Alex E. Pozhitkov, Ruben D. Carrasco, Yin P Hung, Moshe Lapidot, James D. Griffin, Sunil Sharma, Martin Sattler, Raphael Bueno, Klaus Podar, David A. Frank, Sarah R. Walker, Srinivas Vinod Saladi, Swati Garg, Ellen Weisberg, Ravi Salgia, Prakash Kulkarni, Wei Ni
Publikováno v:
British Journal of Cancer
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A
Autor:
Wei Huang, Yunkai Yang, Shuai Leng, Yanli Ren, Jingyao Zhang, Miaomiao Huo, Yan Wang, Dandan Feng, Yang Yang, Tianyang Gao, Wei Liu, Yang Chen
Publikováno v:
Cell Death and Differentiation
Pancreatic cancer is a common malignant tumor with poor prognosis. Recently, cancer stem cells (CSCs) were identified in several solid tumors, including pancreatic cancer. Although accumulating evidence indicates that sirtuin 1 (SIRT1) exerts biologi
Autor:
Siqi Gao, Pucheng Mei, Yongming Wang, Baocai Gao, Feiyan Xie, Chen Ding, Jixi Li, Jiasong Pan, Xiangjun Chen, Jiaxue Wu, Wenqing Gao, Sen Wang, Rui Ge
Publikováno v:
Cell Death and Differentiation
Receptor interacting protein kinase 3 (RIP3 or RIPK3), the critical executor of cell programmed necrosis, plays essential roles in maintaining immune responses and appropriate tissue homeostasis. Although the E3 ligases CHIP and PELI1 are reported to
Publikováno v:
Molecular Psychiatry
Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with th
Autor:
Tao Yan, Zongming Song, Xi Yang, Wencan Wu, Xin Ju, Jia Qu, Shilong Ying, Beibei Wu, Huaicheng Chen, Zong-Duan Zhang, Yi Wang
Publikováno v:
Experimental & Molecular Medicine
Modified LDL-induced inflammation and oxidative stress are involved in the pathogenesis of diabetic retinopathy. Recent studies have also shown that modified LDL activates Toll-like receptor 4 (TLR4) to mediate retinal injury. However, the mechanism
Autor:
Stefan Schulte-Merker, Sasja Blokzijl-Franke, Philippe Herbomel, Jeroen den Hertog, Karima Kissa, Bas Ponsioen, Suma Choorapoikayil
Publikováno v:
Oncogene
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial