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Autor:
Siqi Gao, Pucheng Mei, Yongming Wang, Baocai Gao, Feiyan Xie, Chen Ding, Jixi Li, Jiasong Pan, Xiangjun Chen, Jiaxue Wu, Wenqing Gao, Sen Wang, Rui Ge
Publikováno v:
Cell Death and Differentiation
Receptor interacting protein kinase 3 (RIP3 or RIPK3), the critical executor of cell programmed necrosis, plays essential roles in maintaining immune responses and appropriate tissue homeostasis. Although the E3 ligases CHIP and PELI1 are reported to
Autor:
Xinhui Lan, Simeng Wang, Chao Feng, Haihong Zhang, Qingqing Gu, Meiju Ji, Liang Shi, Yuelei Zhao, Xi Su, Peng Hou, Wei Qiang
Publikováno v:
Cell Death and Differentiation
Small nucleolar RNA SNORD50A and SNORD50B (SNORD50A/B) has been reported to be recurrently deleted and function as a putative tumor suppressor in different types of cancer by binding to and suppressing the activity of the KRAS oncoproteins. Its delet
Publikováno v:
Cell Death and Differentiation
Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline. Despite millions of people being affected worl
Publikováno v:
Cell Death and Differentiation
Despite recent advances in our understanding of the disease, glioblastoma (GB) continues to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify this heterogeneous malignancy using molecular classifiers iden
Autor:
Fangfang Zhao, Chunbao Zang, Fengmei Chao, Hui Deng, Youguang Pu, Ran Xia, Minghua Xie, Lingsuo Kong, Yiao Tan, Fangfang Ge, Shanbao Cai, Dabing Huang, Yueyin Pan, Cifeng Cai
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-15 (2021)
Long-noncoding RNAs (lncRNAs) play roles in regulating cellular functions. High-throughput sequencing analysis identified a new lncRNA, termed LAMTOR5-AS1, the expression of which was much higher in the chemosensitive osteosarcoma (OS) cell line G-29
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 52, Iss 6, Pp 931-939 (2020)
Experimental and Molecular Medicine, Vol 52, Iss 6, Pp 931-939 (2020)
The ubiquitin family member SUMO is a covalent regulator of proteins that functions in response to various stresses, and defects in SUMO-protein conjugation or deconjugation have been implicated in multiple diseases. The loss of the Ulp2 SUMO proteas
Autor:
Robb E. Moses, Xiaotao Li, Rifeng Gao, Wenlong Yang, Junbo Ge, Aijun Sun, Yifan Xie, Zheng Dong, Yang Gao
Publikováno v:
Cell Death and Differentiation
Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner.
Autor:
Seung Ri Lee, Jaewhan Song, Young Jin, Jin-Ho Seo, Peter Vandenabeele, Young Woo Nam, Han Woong Lee, Choong Sil Lee, Doo Byoung Oh, Daehyeon Seong, Chi Hyun Hwang
Publikováno v:
Cell Death and Differentiation
CELL DEATH AND DIFFERENTIATION
CELL DEATH AND DIFFERENTIATION
Necroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood. Here, we identified that Bec
Autor:
Hua Yu, Jun Ding, Yao Jing, Hongwen Zhu, Heng-Li Tian, Gang Wang, Hu Zhou, Xiongjun Wang, Ke Tang
Publikováno v:
Cell Death and Differentiation
The lysyl oxidase (LOX) family is closely related to the progression of glioma. To ensure the clinical significance of LOX family in glioma, The Cancer Genome Atlas (TCGA) database was mined and the analysis indicated that higher LOXL1 expression was
Autor:
Shanshan Wang, Yingqiu Zhang, Fang Liu, Yueguang Wu, Shuyan Liu, Mohamed Y. Zaky, Waleed Yousuf, Han Liu, Jinrui Zhang, Yang Wang, Man Li, Qianhui Sun, Dong Guo, Taishu Wang, Yulin Shi, Qiong Li
Publikováno v:
Cell Death and Differentiation
ErbB2 overexpression identifies a subclass of breast cancer as ErbB2-positive that is frequently associated with poor prognosis. Current ErbB2-targeted therapies have profoundly improved patient outcomes, but mutations occurring in ErbB2 have been sh