Zobrazeno 1 - 10
of 203
pro vyhledávání: ''
Autor:
Yaoqin Gong, Limei Xu, Qiao Liu, Tingting Yang, Jing Wang, Xiyu Zhang, Guosheng Lv, Wenqing Bu, Changshun Shao, Xiaojie Liu, Dong Hou, Xiaohe Hao
Publikováno v:
Oncogene
Reactive oxygen species (ROS) serve as critical signals in various cellular processes. Excessive ROS cause cell death or senescence and mediates the therapeutic effect of many cancer drugs. Recent studies showed that ROS increasingly accumulate durin
Autor:
Ayesha A. Shafi, Peter T. Gallagher, Renée de Leeuw, Jennifer J. McCann, Emanuela Dylgjeri, Christopher McNair, Neermala Poudel Neupane, Amy C. Mandigo, Matthew J. Schiewer, Irina A. Vasilevskaya, Karen E. Knudsen
Publikováno v:
Oncogene
The tumor suppressor gene TP53 is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Specifically, missense mutations in TP53 are selectively enriched in PCa, and cluster to particular “hot spots” in the p
Publikováno v:
Oncogene
Induced waves of calcium fluxes initiate multiple signalling pathways that play an important role in the differentiation and maturation of B-cells. Finely tuned transient Ca+2fluxes from the endoplasmic reticulum in response to B-cell receptor (BCR)
Autor:
Wenkai Zhu, Yunxian Dong, Pu Cheng, Yue Yan, Changlin Zhang, Jiayuan Zhu, Wuguo Deng, Bing Tang, Shaobin Huang, Xiaoling Cao, Miao Chen, Peng Wang, Dingbo Shi, Zhicheng Hu, Chuanbo Xie, Hailin Xu
Publikováno v:
Oncogene
We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the treatment of melanoma because of acquired r
Autor:
Yanqing Ding, Chuan-Sha Gu, Xiao-Yan Wang, Yan Zhong, Jing-Yi Tang, Ling-Fang Gao, Yi-Dan Ma, Zhi-Yan Hu, Xia Wang, Zu-Guo Li, Jia-Xian Zhu, Ting Long
Publikováno v:
Cell Death and Differentiation
Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours that can predict the risk of CRC metastasis is now urgently needed. In this study, we identified aut
Autor:
Qixiang Li, Xiangwei Zeng, Jian Cao, Xinyu Li, Yexuan Deng, Dongjun Yang, Haiqin Jiang, Dake Li, Peipei Xu, Bing Chen, Ying Wang, Quan Zhao, Tao Gui, Ming Liu, David C.S. Huang, Bing Yao, Guiping Wan, Liqin Zhou, Zhihui Wang, Ke Zen
Publikováno v:
Cell Death and Differentiation
Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, the molecular mechanisms underlying EC progression are still largely unknown, and chemotherapeutic options for EC patients are currently very limited. In this stu
Autor:
Wei Huang, Yunkai Yang, Shuai Leng, Yanli Ren, Jingyao Zhang, Miaomiao Huo, Yan Wang, Dandan Feng, Yang Yang, Tianyang Gao, Wei Liu, Yang Chen
Publikováno v:
Cell Death and Differentiation
Pancreatic cancer is a common malignant tumor with poor prognosis. Recently, cancer stem cells (CSCs) were identified in several solid tumors, including pancreatic cancer. Although accumulating evidence indicates that sirtuin 1 (SIRT1) exerts biologi
Autor:
Siqi Gao, Pucheng Mei, Yongming Wang, Baocai Gao, Feiyan Xie, Chen Ding, Jixi Li, Jiasong Pan, Xiangjun Chen, Jiaxue Wu, Wenqing Gao, Sen Wang, Rui Ge
Publikováno v:
Cell Death and Differentiation
Receptor interacting protein kinase 3 (RIP3 or RIPK3), the critical executor of cell programmed necrosis, plays essential roles in maintaining immune responses and appropriate tissue homeostasis. Although the E3 ligases CHIP and PELI1 are reported to
Publikováno v:
Molecular Psychiatry
Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with th
Autor:
Tao Yan, Zongming Song, Xi Yang, Wencan Wu, Xin Ju, Jia Qu, Shilong Ying, Beibei Wu, Huaicheng Chen, Zong-Duan Zhang, Yi Wang
Publikováno v:
Experimental & Molecular Medicine
Modified LDL-induced inflammation and oxidative stress are involved in the pathogenesis of diabetic retinopathy. Recent studies have also shown that modified LDL activates Toll-like receptor 4 (TLR4) to mediate retinal injury. However, the mechanism