Zobrazeno 1 - 10
of 21
pro vyhledávání: ''
Autor:
Graham Belfield, Doris Rassl, Damian C. Crowther, Richard Berks, Ewa Kolosionek, Helen Parfrey, Marisa Coetzee, Nicola Davis, Maryam Clausen, Susan J. Monkley, Overed-Sayer Catherine L, Cory M. Hogaboam, Leire Escudero-Ibarz, Lynne Murray, Leia R. Griffin, Maria Karlsson, Alan Carruthers
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of normal ri
Autor:
Kimberly S. Smythe, Darci J. Phillips, Robert H. Pierce, Salil S. Bhate, Yury Goltsev, Youn H. Kim, Magdalena Matusiak, Christian M. Schürch, Steven P. Fling, Garry P. Nolan, Martin A. Cheever, Janos Demeter, Graham L. Barlow, Sizun Jiang, Nirasha Ramchurren, Robert West, Michael S. Khodadoust, Belén Rivero Gutierrez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform C
Autor:
Xincheng Wu, Zhengping Bai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Epigenetic modifications, especially N6-methyladenosine (m6A) modification, play a key role in tumor microenvironment (TME) infiltration. However, the regulatory role of m6A modification in the TME of lung adenocarcinoma (LUAD) remains unclear. A tot
Autor:
Mehmet Asim Bilen, Mert Boya, Bassel F. El-Rayes, A. Fatih Sarioglu, Mehmet Akce, Omer Kucuk, Chia-Heng Chu, Tevhide Ozkaya-Ahmadov, Ruxiu Liu, Brandi E. Swain
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Reliable and routine isolation of circulating tumor cells (CTCs) from peripheral blood would allow effective monitoring of the disease and guide the development of personalized treatments. Negative enrichment of CTCs by depleting normal blood cells e
Autor:
Robert S. Fulton, Matthew A. Wyczalkowski, Christopher J. Yoon, Justin King, Steven M. Foltz, Timothy J. Ley, Julie O'Neal, Ravi Vij, Erik Storrs, Ruiyang Liu, Amila Weerasinghe, Julia Tianjiao Wang, Scott R. Goldsmith, Hua Sun, Michael C. Wendl, Michael P. Rettig, Stephen T. Oh, Song Cao, Mark A. Fiala, Catrina Fronick, Daniel R. Kohnen, Sunantha Sethuraman, Lijun Yao, John F. DiPersio, Reyka G Jayasinghe, Jared S. Fowles, Joshua F. McMichael, Li Ding, Qingsong Gao
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. Despite recent treatment advances, it is still incurable as disease progression is not fully understood. To investigate MM and its immune environment, we apply
Autor:
Gergő Papp, Gábor Lendvai, Ilona Kovalszky, Gábor Lotz, András Kiss, Éva Kocsmár, Attila Szijártó, Ildikó Kocsmár, Zsuzsa Schaff, Luca Szalai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Small subtype of the gastrointestinal stromal tumor (micro-GIST, MG) is usually asymptomatic and is frequently found incidentally in association with gastric adenocarcinoma (GAC). The background of this coincidence is still an open question. This stu
Autor:
Wenyang Huang, Hui Cheng, Shuang Xia, Wen Zhou, Junqiang Lv, Tao Cheng, Xuehan Mao, Weiwei Sui, Gang An, Chenxing Du, Shuhui Deng, Mu Hao, Xiaoke Ma, Jie Xu, Zhen Yu, Lanting Liu, Lugui Qiu, Xiaojing Wei
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Anaemia is the most common complication of myeloma and is associated with worse clinical outcomes. Although marrow replacement with myeloma cells is widely considered a mechanistic rationale for anaemia, the exact process has not been fully understoo
Autor:
Myung-Ju Ahn, Mi Soon Kim, Keunchil Park, Jin Seok Ahn, Kyoung Young Lee, Jiae Koh, Joon Young Hur, Bo Mi Ku, Se-Hoon Lee, Jong-Mu Sun, Jae Yeong Heo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Antitumor immune responses induced by immune checkpoint inhibitors anti-PD-1 or anti-PD-L1 have been used as therapeutic strategies in advanced non-small cell lung cancer (NSCLC) patients over the last decade. Favorable antitumor activity to immune c
Subcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis
Autor:
Jun-Kang Shao, Feng Shao, Chih-Hsin Tang, Chao-Qun Wang, Hongchuan Jin, Bifei Huang, Yan Wang, Yue Zeng, Qian Wang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
The high-mobility group box-1 (HMGB1) protein is implicated in the development of various cancers and their proliferation. According to its function, HMGB1 shuttles between the cell nucleus and cytoplasm, assisting with nucleosome stabilization and g
Autor:
Mai Suzuki, J. Luis Espinoza, Yuzuru Kanakura, Itaru Matsumura, Kenji Oritani, Shinya Rai, Takafumi Yokota, Akira Tanimura, Toshio Watanabe, Takahiro Kumode, Hirokazu Tanaka
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutated receptor tyrosine kinases (MT-RTKs) such as internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3 ITD) and a point mutation KIT D816V are driver mutations for acute myeloid leukemia (AML). Clathrin assembly lymphoid myeloid leukemia