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Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 5, Pp 1-8 (2021)
Cell Death and Disease, Vol 12, Iss 5, Pp 1-8 (2021)
Small-cell carcinoma of the esophagus (SCCE) is a rare and aggressive cancer. Although several consistent genomic changes were observed previously between SCCE and small-cell lung cancer (SCLC), detailed mutational landscapes revealing discrepancies
Autor:
Robert S. Fulton, Matthew A. Wyczalkowski, Christopher J. Yoon, Justin King, Steven M. Foltz, Timothy J. Ley, Julie O'Neal, Ravi Vij, Erik Storrs, Ruiyang Liu, Amila Weerasinghe, Julia Tianjiao Wang, Scott R. Goldsmith, Hua Sun, Michael C. Wendl, Michael P. Rettig, Stephen T. Oh, Song Cao, Mark A. Fiala, Catrina Fronick, Daniel R. Kohnen, Sunantha Sethuraman, Lijun Yao, John F. DiPersio, Reyka G Jayasinghe, Jared S. Fowles, Joshua F. McMichael, Li Ding, Qingsong Gao
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. Despite recent treatment advances, it is still incurable as disease progression is not fully understood. To investigate MM and its immune environment, we apply
Autor:
Myung-Ju Ahn, Mi Soon Kim, Keunchil Park, Jin Seok Ahn, Kyoung Young Lee, Jiae Koh, Joon Young Hur, Bo Mi Ku, Se-Hoon Lee, Jong-Mu Sun, Jae Yeong Heo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Antitumor immune responses induced by immune checkpoint inhibitors anti-PD-1 or anti-PD-L1 have been used as therapeutic strategies in advanced non-small cell lung cancer (NSCLC) patients over the last decade. Favorable antitumor activity to immune c
Autor:
Kaori Kuramitsu, Makoto Miyamoto, Lin-Lin Wei, Kahini A. Vaid, Shuangshuang Zhao, Yury Popov, Michelle Lai, Deanna Y. Sverdlov, Ping An
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Due to their bacterial ancestry, many components of mitochondria share structural similarities with bacteria. Release of molecular danger signals from injured cell mitochondria (mitochondria-derived damage-associated molecular patterns, mito-DAMPs) t
Publikováno v:
Scientific Data
Scientific Data, Vol 6, Iss 1, Pp 1-15 (2019)
Scientific Data, Vol 6, Iss 1, Pp 1-15 (2019)
T cells, as a crucial compartment of the tumour microenvironment, play vital roles in cancer immunotherapy. However, the basic properties of tumour-infiltrating T cells (TILs) such as the functional state, migratory capability and clonal expansion re
Autor:
Li Zhu, George C. Tseng, Bennett Van Houten, Adrian V. Lee, Kevin M. Levine, Nilgun Tasdemir, Steffi Oesterreich, Tian Du, Dario A. A. Vignali
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer following invasive ductal carcinoma (IDC). ILC differs from IDC in a number of histological and clinical features, such as single strand growth, difficul
Autor:
Yajing Chen, Yuanjie Niu, Yiting Wang, Yong Wang, Wei Zhai, Dan Yue, Hua Geng, Jing Su, Donghe Fu, Xin Li
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 5, Pp 1-13 (2018)
Cell Death and Disease, Vol 9, Iss 5, Pp 1-13 (2018)
The chronic inflammatory microenvironment within or surrounding the primary renal cell carcinoma (RCC) site promotes oncogenic transformation as well as contributes to the development of metastasis. G3BP stress granule assembly factor 1 (G3BP1) was f
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 3, Pp 1-13 (2018)
Cell Death and Disease, Vol 9, Iss 3, Pp 1-13 (2018)
Regulatory T cells in rejected allograft patients display an inability to control responder T cells. Galectin-1 (Gal1) inhibits responder T cells through binding CD7. We investigated whether the dysfunctional immunoregulation in liver allograft rejec
Autor:
Ondrej Slaby, Jiri Sana, Marek Hilser, Martin Smrčka, Radim Lipina, Lenka Radová, Lucie Sromova, Štefan Reguli, Aleksi Sedo, Petr Busek, Radek Lakomy, Leos Kren, Andrej Bešše, Pavel Fadrus, Marek Vecera
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant treatment. MicroRNAs (miRNAs) are small, non-coding RNAs controlling gene expression at the pos