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Autor:
Natalia Voronina, Aurélie Ernst, Marc Zapatka, Gino Cioffi, Jill S. Barnholtz-Sloan, Andreas von Deimling, David T.W. Jones, Marina Ryzhova, Christian Aichmüller, Stefan M. Pfister, Thorsten Kolb, Andrey Korshunov, Martin Sill, Jan Gronych, Jonas Frisén
Publikováno v:
Oncogene
Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adultho
Autor:
Kasper Adelborg, Dóra Körmendiné Farkas, Mads Okkels Birk Lorenzen, Henrik Toft Sørensen, Jens Sundbøll
Publikováno v:
British Journal of Cancer
Lorenzen, M O B, Farkas, D K, Adelborg, K, Sundbøll, J & Sørensen, H T 2020, ' Syncope as a sign of occult cancers : a population-based cohort study ', British Journal of Cancer, vol. 122, no. 4, pp. 595-600 . https://doi.org/10.1038/s41416-019-0692-2
Lorenzen, M O B, Farkas, D K, Adelborg, K, Sundbøll, J & Sørensen, H T 2020, ' Syncope as a sign of occult cancers : a population-based cohort study ', British Journal of Cancer, vol. 122, no. 4, pp. 595-600 . https://doi.org/10.1038/s41416-019-0692-2
Background We examined if syncope was a marker of an occult cancer by comparing the risk in patients with a syncope episode with that of the general population. Methods Using Danish population-based medical registries, we identified all patients diag
Autor:
Philip George, Yvette Hoade, Sahra Ali, Simon Watt, Varun Mehra, Catherine Cargo, Fergus Jack, Paul Evans, Tiziana Fanelli, William J. Tapper, Alastair Whiteway, Gabriela Sciuccati, Iwo Pieniak, Jamie Cavenagh, Emma Das-Gupta, Andres Virchis, Nicole Naumann, Kavita Patel, Rowena Thomas-Dewing, Patrick Thornton, Kris Zegocki, Louise Wallis, Charlotte Grimley, Gonzalo Carreño-Tarragona, Peter Forsyth, Andreas Reiter, Nicholas C.P. Cross, Laura Munro, Kaljit Bhuller, Andrew S Duncombe, Andrew Chase, Barbara J. Bain, Mohamad Jawhar, Johannes Lübke, Ali Rismani, Sonja Burgstaller
Publikováno v:
Leukemia
Cross, N C P, Hoade, Y, Tapper, W J, Carreno-tarragona, G, Fanelli, T, Jawhar, M, Naumann, N, Pieniak, I, Lübke, J, Ali, S, Bhuller, K, Burgstaller, S, Cargo, C, Cavenagh, J, Duncombe, A S, Das-gupta, E, Evans, P, Forsyth, P, George, P, Grimley, C, Jack, F, Munro, L, Mehra, V, Patel, K, Rismani, A, Sciuccati, G, Thomas-dewing, R, Thornton, P, Virchis, A, Watt, S, Wallis, L, Whiteway, A, Zegocki, K, Bain, B J, Reiter, A & Chase, A 2018, ' Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia ', Leukemia . https://doi.org/10.1038/s41375-018-0342-3
Cross, N C P, Hoade, Y, Tapper, W J, Carreno-tarragona, G, Fanelli, T, Jawhar, M, Naumann, N, Pieniak, I, Lübke, J, Ali, S, Bhuller, K, Burgstaller, S, Cargo, C, Cavenagh, J, Duncombe, A S, Das-gupta, E, Evans, P, Forsyth, P, George, P, Grimley, C, Jack, F, Munro, L, Mehra, V, Patel, K, Rismani, A, Sciuccati, G, Thomas-dewing, R, Thornton, P, Virchis, A, Watt, S, Wallis, L, Whiteway, A, Zegocki, K, Bain, B J, Reiter, A & Chase, A 2018, ' Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia ', Leukemia . https://doi.org/10.1038/s41375-018-0342-3
Determining the underlying cause of persistent eosinophilia is important for effective clinical management but remains a diagnostic challenge in many cases. We identified STAT5B N642H, an established oncogenic mutation, in 27/1715 (1.6%) cases referr
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 6, Pp 1-11 (2020)
Cell Death and Disease, Vol 11, Iss 6, Pp 1-11 (2020)
Heparan sulfate proteoglycan 2 (HSPG2), also known as perlecan, is a large multi-domain extracellular matrix proteoglycan, which contributes to the invasion, metastasis and angiogenesis of solid tumor. However, very little is known about the effect o
Autor:
Audrey Duquette, Vincent A. Miller, Aly-Khan A. Lalani, Toni K. Choueiri, Siraj M. Ali, A. Ari Hakimi, Stephanie A. Wankowicz, Lauren Young, Jeffrey S. Ross, Sabina Signoretti, Sumanta K. Pal, Russell Madison, Dominick Bossé, Guillermo de Velasco, Philip J. Stephens, Craig Norton
Publikováno v:
British Journal of Cancer
Background The genomic landscape of primary clear cell renal cell carcinoma (ccRCC) has been well described. However, little is known about cohort genomic alterations (GA) landscape in ccRCC metastases, or how it compares to primary tumours in aggreg