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Autor:
Derong Xie, Won Seog Kim, Yuan Zhu, Xin Du, Ting Liu, Junxin Wu, Tao Wu, Pingyong Yi, Yanming Deng, Xiangyuan Wu, Gang Wu, Xiaoyan Ke, Huangming Hong, Jie Jin, Ye Guo, Wei-Li Zhao, Kangsheng Gu, Fanyi Meng, Mingzhi Zhang, Zhigang Peng, Jinghua Wang, Jun Zhu, Tongyu Lin, Daren Lin, Chaoyong Liang, Qing Liu, He Huang, Juan Li, Soon Thye Lim, Yexiong Li
Publikováno v:
Leukemia
Autor:
Kasper Adelborg, Dóra Körmendiné Farkas, Mads Okkels Birk Lorenzen, Henrik Toft Sørensen, Jens Sundbøll
Publikováno v:
British Journal of Cancer
Lorenzen, M O B, Farkas, D K, Adelborg, K, Sundbøll, J & Sørensen, H T 2020, ' Syncope as a sign of occult cancers : a population-based cohort study ', British Journal of Cancer, vol. 122, no. 4, pp. 595-600 . https://doi.org/10.1038/s41416-019-0692-2
Lorenzen, M O B, Farkas, D K, Adelborg, K, Sundbøll, J & Sørensen, H T 2020, ' Syncope as a sign of occult cancers : a population-based cohort study ', British Journal of Cancer, vol. 122, no. 4, pp. 595-600 . https://doi.org/10.1038/s41416-019-0692-2
Background We examined if syncope was a marker of an occult cancer by comparing the risk in patients with a syncope episode with that of the general population. Methods Using Danish population-based medical registries, we identified all patients diag
Autor:
Sum-Yin Chan, To-Wai Leung, Chi-Chung Tong, Ka-On Lam, John M. Nicholls, Sik-Kwan Chan, Victor Ho-Fun Lee, Mai-Yee Luk, Ka-Chun Tsang, Dora L.W. Kwong, Cheuk-Wai Choi, Anne Wing-Mui Lee, Tsz-Him So, Pek-Lan Khong
Publikováno v:
British Journal of Cancer
Background Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in endemic regions may have undetectable plasma EBV DNA. Methods We prospectively recruited 518 patients with non-metastatic NPC and measured their pre-treatment plasma EBV
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
The CXC chemokine receptor 4 (CXCR4) exerts a variety of functions at different steps of hepatocellular carcinoma (HCC) progression. The molecular mechanisms and therapeutic value of CXCR4 in the development of HCC remain undefined. Here we show that
Publikováno v:
British Journal of Cancer
Background Combinations of inflammatory markers are used as prognostic scores in cancer patients with cachexia. We investigated whether they could also be used to prioritise patients attending primary care with unexpected weight loss for cancer inves
Autor:
Buwen Yao, Xiaolin Ji, Jiang-feng You, Fang Mei, Rui Wu, Xinyang Li, Fei Pei, Yan Liu, Mengxue Zhang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
The screening of non-small cell lung cancer (NSCLC) tumors for anaplastic lymphoma receptor tyrosine kinase (ALK) gene rearrangements is important because of the dramatically favorable therapy response to ALK inhibitor. However, the exact mechanism o
Autor:
Norikatsu Miyoshi, Masayuki Ohue, Shiki Fujino, Mamoru Uemura, Aya Ito, Tsunekazu Mizushima, Masayoshi Yasui, Chu Matsuda, Yuichiro Doki, Hidetoshi Eguchi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells. Here, we identified the CRC-specific gene, HNF1A, which is the
Autor:
Philip George, Yvette Hoade, Sahra Ali, Simon Watt, Varun Mehra, Catherine Cargo, Fergus Jack, Paul Evans, Tiziana Fanelli, William J. Tapper, Alastair Whiteway, Gabriela Sciuccati, Iwo Pieniak, Jamie Cavenagh, Emma Das-Gupta, Andres Virchis, Nicole Naumann, Kavita Patel, Rowena Thomas-Dewing, Patrick Thornton, Kris Zegocki, Louise Wallis, Charlotte Grimley, Gonzalo Carreño-Tarragona, Peter Forsyth, Andreas Reiter, Nicholas C.P. Cross, Laura Munro, Kaljit Bhuller, Andrew S Duncombe, Andrew Chase, Barbara J. Bain, Mohamad Jawhar, Johannes Lübke, Ali Rismani, Sonja Burgstaller
Publikováno v:
Leukemia
Cross, N C P, Hoade, Y, Tapper, W J, Carreno-tarragona, G, Fanelli, T, Jawhar, M, Naumann, N, Pieniak, I, Lübke, J, Ali, S, Bhuller, K, Burgstaller, S, Cargo, C, Cavenagh, J, Duncombe, A S, Das-gupta, E, Evans, P, Forsyth, P, George, P, Grimley, C, Jack, F, Munro, L, Mehra, V, Patel, K, Rismani, A, Sciuccati, G, Thomas-dewing, R, Thornton, P, Virchis, A, Watt, S, Wallis, L, Whiteway, A, Zegocki, K, Bain, B J, Reiter, A & Chase, A 2018, ' Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia ', Leukemia . https://doi.org/10.1038/s41375-018-0342-3
Cross, N C P, Hoade, Y, Tapper, W J, Carreno-tarragona, G, Fanelli, T, Jawhar, M, Naumann, N, Pieniak, I, Lübke, J, Ali, S, Bhuller, K, Burgstaller, S, Cargo, C, Cavenagh, J, Duncombe, A S, Das-gupta, E, Evans, P, Forsyth, P, George, P, Grimley, C, Jack, F, Munro, L, Mehra, V, Patel, K, Rismani, A, Sciuccati, G, Thomas-dewing, R, Thornton, P, Virchis, A, Watt, S, Wallis, L, Whiteway, A, Zegocki, K, Bain, B J, Reiter, A & Chase, A 2018, ' Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia ', Leukemia . https://doi.org/10.1038/s41375-018-0342-3
Determining the underlying cause of persistent eosinophilia is important for effective clinical management but remains a diagnostic challenge in many cases. We identified STAT5B N642H, an established oncogenic mutation, in 27/1715 (1.6%) cases referr
Autor:
Asher Chanan-Khan, Olga Samoilova, Charles Phelps, Michelle Mahler, Javier Loscertales, Dirceu Villa Villa, Ann Janssens, Andre Goy, M. Salman, Simon Rule, Claes Karlsson, Miguel A. Pavlovsky, Graeme Fraser, Angela Howes, Alexander Pristupa, Steven Sun, Marie-Sarah Dilhuydy, Abraham Avigdor, Paula Cramer, Panagiotis Panagiotidis, Nancy L. Bartlett, Sriram Balasubramanian, Jiří Mayer, Fatih Demirkan, R. Santucci Silva, Sebastian Grosicki, Halyna Pylypenko, Michael Hallek
Publikováno v:
Leukemia
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
We report follow-up results from the randomized, placebo-controlled, phase 3 HELIOS trial of ibrutinib+bendamustine and rituximab (BR) for previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) without deletion 17p. Ov
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 6, Pp 1-11 (2020)
Cell Death and Disease, Vol 11, Iss 6, Pp 1-11 (2020)
Heparan sulfate proteoglycan 2 (HSPG2), also known as perlecan, is a large multi-domain extracellular matrix proteoglycan, which contributes to the invasion, metastasis and angiogenesis of solid tumor. However, very little is known about the effect o