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Publikováno v:
Oncogene
Induced waves of calcium fluxes initiate multiple signalling pathways that play an important role in the differentiation and maturation of B-cells. Finely tuned transient Ca+2fluxes from the endoplasmic reticulum in response to B-cell receptor (BCR)
Autor:
Wenkai Zhu, Yunxian Dong, Pu Cheng, Yue Yan, Changlin Zhang, Jiayuan Zhu, Wuguo Deng, Bing Tang, Shaobin Huang, Xiaoling Cao, Miao Chen, Peng Wang, Dingbo Shi, Zhicheng Hu, Chuanbo Xie, Hailin Xu
Publikováno v:
Oncogene
We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the treatment of melanoma because of acquired r
Autor:
Imran Ahmad, Laura C. A. Galbraith, Gillian M. Mackay, Ernest Mui, Colin Nixon, Owen J. Sansom, Hing Y. Leung, David Sumpton, Ann Hedley, David P. Strachan
Publikováno v:
Oncogene
Peroxisome Proliferator-Activated Receptor Gamma (PPARG) is one of the three members of the PPAR family of transcription factors. Besides its roles in adipocyte differentiation and lipid metabolism, we recently demonstrated an association between PPA
Autor:
Kyle N. Cowan, Tommy Alain, Stephen Baird, Xiao Xiang, Stéphanie Langlois, Tyson E. Graber, Marie-Eve St-Pierre, Stephanie L. Fowler, Anna Blinder, Steffany A. L. Bennett, Philippe Charron
Publikováno v:
Oncogene
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, is an aggressive cancer with a poor prognosis. Despite current management, the 5-year survival rate for patients with metastatic RMS is ∼30%; underscoring the need to develop
Autor:
Amy Li, Daniel Martinez, Busra Turgu, Luigi Tortola, Christopher S. Hughes, Fan Zhang, Tony Ng, Poul H. Sorensen, Melanie Kogler, Fraser Johnson, Josef M. Penninger, John M. Maris, William W. Lockwood, Amal El-Naggar, Gian Luca Negri, Donald T. T. Yapp, Mads Daugaard
Publikováno v:
Oncogene
Oncogene, 40 (11)
Oncogene, 40 (11)
Uncovering the mechanisms that underpin how tumor cells adapt to microenvironmental stress is essential to better understand cancer progression. The HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase) gene is a tumor suppres
Autor:
Marco Haselager, Rachel Thijssen, Arnon P. Kater, Christopher West, Roel J. W. van Kampen, Elaine Willmore, Simon P. Mackay, Eric Eldering, Louise C. Young
Publikováno v:
Cell Death and Differentiation
Cell death and differentiation, 28(5), 1658-1668. Nature Publishing Group
Cell death and differentiation, 28(5), 1658-1668. Nature Publishing Group
In chronic lymphocytic leukemia (CLL), the lymph node (LN) microenvironment delivers critical survival signals by inducing the expression of anti-apoptotic Bcl-2 members Bcl-XL, Bfl-1, and Mcl-1, resulting in apoptosis blockade. We determined previou
Autor:
Guido Forni, Alberto Mantovani
Publikováno v:
Cell Death and Differentiation
Cell Death & Differentiation
Cell Death & Differentiation
In the eleven months elapsed since the identification of the SARS-CoV-2 virus and its genome, an exceptional effort by the scientific community has led to the development of over 300 vaccine projects. Over 40 are now undergoing clinical evaluation, t
Autor:
Linguo Xu, Lin Huan, Xianghuo He, Qifeng Wang, Shenglin Huang, Yangjun Wu, Tianan Guo, Yanfang Liu, Ye Xu, Linhui Liang
Publikováno v:
Oncogene
Epigenetic alteration is one of the hallmarks of colorectal cancer (CRC). Many driver genes are regulated by DNA methylation in CRC. However, the role of DNA methylation regulating lncRNAs remain elusive. Here, we identify that SNHG11 (small nucleola
Autor:
Dong Gwang Lee, Young-Lai Cho, Young-Jun Park, Nayoung Kim, Jin-Man Kim, Jeong-Ki Min, Kwang-Hee Bae, Seon-Jin Lee, Hyun-Soo Cho, Jangwook Lee, Tae-Su Han, Hyo Jin Lee, Heung Jin Jeon, Sang-Hyun Lee, Jang-Seong Kim, Mina Joo, Moo-Seung Lee, Deog Yeon Jo, Hwan Jung Yun, Yong Min Huh, Jong-Gil Park
Publikováno v:
Cell Death and Differentiation
Gallbladder carcinoma (GBC) exhibits poor prognosis due to local recurrence, metastasis, and resistance to targeted therapies. Using clinicopathological analyses of GBC patients along with molecular in vitro and tumor in vivo analysis of GBC cells, w
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1310-1325 (2020)
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1310-1325 (2020)
Our study aimed to determine how lncRNA DANCR, miR-320a, and CTNNB1 interact with each other and regulate osteogenic differentiation in osteoporosis. qRT-PCR and western blotting were performed to determine the expression of DANCR, miR-320a, CTNNB1,