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of 475
pro vyhledávání: ''
Autor:
Andrea G. Solano, Yunfei Yang, Evan Reid, Robert Watt, Keith R Martin, Veselina Petrova, James R. Tribble, Richard Eva, Craig S Pearson, Peter A. Williams, Jared Ching, Fiona Love, Andrew Osborne, Herbert M. Geller, James W. Fawcett
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to enhancing regeneration is to increase the axonal supply of growth molecules and organelles. We ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09466af76333d119299a77c0ed33fd53
https://www.repository.cam.ac.uk/handle/1810/312564
https://www.repository.cam.ac.uk/handle/1810/312564
Autor:
Yibu Chen, Steven Balog, Hidekazu Tsukamoto, Yasuhiro Nakano, Stephanie Q. Pan, Meng Li, Raymond Wu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Prominin 1 (PROM1) is one of a few clinically relevant progenitor markers in human alcoholic hepatitis (AH) and hepatocellular carcinoma (HCC), and mouse liver tumor initiating stem cell-like cells (TICs). However, the origin, fate and functions of P
Autor:
Chen Sun, Kunpeng Li, Ruben Vidal, Bernardino Ghetti, Wen Jiang, Barry B. Muhoberac, Jose Irimia-Dominguez, Holly J. Garringer, G.I. Hallinan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
The role of abnormal brain iron metabolism in neurodegenerative diseases is still insufficiently understood. Here, we investigate the molecular basis of the neurodegenerative disease hereditary ferritinopathy (HF), in which dysregulation of brain iro
Autor:
Ee-Shien Tan, John Pappas, Tiffany Busa, Marjolein H. Willemsen, Erica H. Gerkes, Astrid Bruckmann, Linda Ramsdell, Davor Lessel, Chieko Chijiwa, Diana Mitter, Ghayda M. Mirzaa, Peter Ian Andrews, Daniela M. Zeitler, Claudia Schob, Pankaj Prasun, M. E. Suzanne Lewis, Rami Abou Jamra, Andriy Kazantsev, Aida Telegrafi, Steffen Syrbe, Chantal Missirian, Victoria Martens, Kimberly Foss, Margot R.F. Reijnders, Bianca Panis, Ilaria Mannucci, Bernarda Lozić, Fatemeh Hassani Nia, Rolph Pfundt, Tanja Kovacevic, Han G. Brunner, Christian Kubisch, Allyn McConkie-Rosell, Breana Cham, Gunter Meister, Jessika Johannsen, Veronika Graus, Henny H. Lemmink, Stefan Kindler, Jonas Denecke, Kirsty McWalter, Ivana Lessel, Zoya Ignatova, Hans-Jürgen Kreienkamp, Matthew Osmond, Thatjana Gardeitchik, Alexander P.A. Stegmann, Rachel Rabin, Alexander Bartholomäus, Jérémie Mortreux, Katharina Löhner, Tony Roscioli, Tjitske Kleefstra, Taila Hartley, Andreas Merkenschlager, Patrick Rump, Marie T. McDonald, Kym M. Boycott, Evelien Zonneveld-Huijssoon, David A. Dyment, Carey-Anne Evans, Margje Sinnema, Sabine Lüttgen, Joanna Lazier, Diana Le Duc, Kerith-Rae Dias, Ene-Choo Tan
Publikováno v:
Nature Communications
Nature Communications, 11, 1
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-19572-5⟩
Nature Communications, 11(1):5797. Nature Publishing Group
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19572-5⟩
Nature Communications, 11
Nature Communications, 11, 1
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-19572-5⟩
Nature Communications, 11(1):5797. Nature Publishing Group
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19572-5⟩
Nature Communications, 11
ARGONAUTE-2 and associated miRNAs form the RNA-induced silencing complex (RISC), which targets mRNAs for translational silencing and degradation as part of the RNA interference pathway. Despite the essential nature of this process for cellular functi
Autor:
Liane Fernandes, Annemarthe G. van der Veen, Petra Mlcochova, Christopher H.C. Tie, Ravindra K. Gupta, Helen M. Rowe, Rocio Enriquez-Gasca, James Holt, Kathleen H. Burns, Hale Tunbak, Poppy A Gould, Pierre V. Maillard, Evangelos Giampazolias
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1). NATURE PORTFOLIO
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1). NATURE PORTFOLIO
Funder: UKRI Future Leaders Fellowship (MR/S034498/1)
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of
Autor:
Yiwei Chu, Gui Qian, Daqiao Guo, Manman Li, Feng Huang, Yu Wang, Yihua Zhang, Chao Fang, Jing Liu, Zijuan Chen, Quanming Zou, Dapeng Yan, Liuyan Li
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Virus infection may induce excessive interferon (IFN) responses that can lead to host tissue injury or even death. β-arrestin 2 regulates multiple cellular events through the G protein-coupled receptor (GPCR) signaling pathways. Here we demonstrate
Autor:
Simon Haas, Denis Kusevic, Florian Grünschläger, Jozef Zustin, Felix Rosemann, Suman Lee, Dieter Weichenhan, Daniela Mancarella, Maren Kirstin Schuhmacher, Christoph Plass, Kersten Breuer, Anna Jauch, Jinyeong Lim, Simin Öz, Albert Jeltsch, Matthias Schlesner, Dominik Vonficht, Chao Jiang, Reka Toth, Udo Oppermann, Jörg Fellenberg, Yoon Jung Park, Anand Mayakonda, Pavlo Lutsik, Mark Hartmann, Viet Ha Nguyen, Joschka Hey, Florian Haller, Joo Hyun Park, Umut H. Toprak, Alexander Kühn, Anders Lindroth, Annika Baude
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The neoplastic stromal cells of giant cell tumor of bone (GCTB) carry a mutation in H3F3A, leading to a mutant histone variant, H3.3-G34W, as a sole recurrent genetic alteration. We show that in patient-derived stromal cells H3.3-G34W is incorporated
Autor:
Bakhtiar Yamini, Clayton D. Crawley, Longtao Wu, Andrea Garofalo, Olufunmilayo I. Olopade, Jackie W. Nichols, Galina Khramtsova, Ralph R. Weichselbaum, Paige-Ashley Campbell
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
p50, the mature product of NFKB1, is constitutively produced from its precursor, p105. Here, we identify BARD1 as a p50-interacting factor. p50 directly associates with the BARD1 BRCT domains via a C-terminal phospho-serine motif. This interaction is
Autor:
Augusto C. Montezano, Livia L Camargo, Daniel Rodrigues, Rhian M. Touyz, Aikaterini Anagnostopoulou
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Vascular smooth muscle cell (VSMC) function is regulated by Nox-derived reactive oxygen species (ROS) and redox-dependent signaling in discrete cellular compartments. Whether cholesterol-rich microdomains (lipid rafts/caveolae) are involved in these
Autor:
Shouye Wang, Zeng Fan, Xiaojing Zou, Wen Yue, Xuetao Pei, Xie Xiaoyan, Fang Fang, Xu Lei, Lin Chen, Quan Zeng, Mingyi Qu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Thrombosis leads to platelet activation and subsequent degradation; therefore, replenishment of platelets from hematopoietic stem/progenitor cells (HSPCs) is needed to maintain the physiological level of circulating platelets. Platelet-derived microp