Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Metzler, A"'
Autor:
Franziska Gsottberger, Christina Meier, Anna Ammon, Scott Parker, Kerstin Wendland, Rebekka George, Srdjan Petkovic, Lisa Mellenthin, Charlotte Emmerich, Gloria Lutzny-Geier, Markus Metzler, Andreas Mackensen, Vidyalakshmi Chandramohan, Fabian Müller
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)
Abstract Cellular stress responses including the unfolded protein response (UPR) decide over the fate of an individual cell to ensure survival of the entire organism. During physiologic UPR counter-regulation, protective proteins are upregulated to p
Externí odkaz:
https://doaj.org/article/15b35ae762b44e4bbd9c25c7e5e42184
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/49b34b76a0d841dbba9f4b96cbde4918
Autor:
John Patrick Aggleton, Emma Jane Kidd, Jilu P. Mole, John Evans, Claudia Metzler-Baddeley, Fabrizio Fasano, Rebecca Sims
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-25 (2020)
Scientific Reports
Scientific Reports
APOE-ε4 is a main genetic risk factor for developing late onset Alzheimer’s disease (LOAD) and is thought to interact adversely with other risk factors on the brain. However, evidence regarding the impact of APOE-ε4 on grey matter structure in as
Autor:
Zierk, Jakob, Arzideh, Farhad, Kapsner, Lorenz A., Prokosch, Hans-Ulrich, Metzler, Markus, Rauh, Manfred
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Appropriate reference intervals are essential when using laboratory test results to guide medical decisions. Conventional approaches for the establishment of reference intervals rely on large samples from healthy and homogenous reference populations.
Autor:
Śmiłowicz, Dariusz (M. Sc.), Kogelheide, Friederike (Dr.-Ing.), Stapelmann, Katharina (Jun.-Prof, Dr.-Ing.), Awakowicz, Peter (Prof. Dr.-Ing.), Metzler-Nolte, Nils (Prof. Dr. rer. nat.)
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Cold atmospheric pressure plasma is an attractive new research area in clinical trials to treat skin diseases. However, the principles of plasma modification of biomolecules in aqueous solutions remain elusive. It is intriguing how reactive oxygen an
Autor:
John Evans, Jilu P. Mole, Derek K. Jones, Fabrizio Fasano, Claudia Metzler-Baddeley, Roland J. Baddeley, Rebecca Sims, John Patrick Aggleton
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
Scientific Reports
Scientific Reports
Aging leads to gray and white matter decline but their causation remains unclear. We explored two classes of models of age and dementia risk related brain changes. The first class of models emphasises the importance of gray matter: age and risk-relat
Autor:
Erica A. Frankel, Christine D. Keating, Rebecca M. Guth-Metzler, Andrew J. Veenis, Philip C. Bevilacqua, Raghav R. Poudyal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Membraneless compartments, such as complex coacervates, have been hypothesized as plausible prebiotic micro-compartments due to their ability to sequester RNA; however, their compatibility with essential RNA World chemistries is unclear. We show that
Autor:
Bettina Sobottka, Marta Nowak, Anja Laura Frei, Martina Haberecker, Samuel Merki, Mitchell P. Levesque, Reinhard Dummer, Holger Moch, Viktor Hendrik Koelzer, Rudolf Aebersold, Melike Ak, Faisal S. Al-Quaddoomi, Jonas Albinus, Ilaria Alborelli, Sonali Andani, Per-Olof Attinger, Marina Bacac, Daniel Baumhoer, Beatrice Beck-Schimmer, Niko Beerenwinkel, Christian Beisel, Lara Bernasconi, Anne Bertolini, Bernd Bodenmiller, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Natalia Chicherova, Maya D'Costa, Esther Danenberg, Natalie Davidson, Monica-Andreea Drăganmoch, Stefanie Engler, Martin Erkens, Katja Eschbach, Cinzia Esposito, André Fedier, Pedro Ferreira, Joanna Ficek, Bruno Frey, Sandra Goetze, Linda Grob, Gabriele Gut, Detlef Günther, Pirmin Haeuptle, Viola Heinzelmann-Schwarz, Sylvia Herter, Rene Holtackers, Tamara Huesser, Anja Irmisch, Francis Jacob, Andrea Jacobs, Tim M. Jaeger, Katharina Jahn, Alva R. James, Philip M. Jermann, André Kahles, Abdullah Kahraman, Werner Kuebler, Jack Kuipers, Christian P. Kunze, Christian Kurzeder, Kjong-Van Lehmann, Sebastian Lugert, Gerd Maass, Markus G. Manz, Philipp Markolin, Julien Mena, Ulrike Menzel, Julian M. Metzler, Nicola Miglino, Emanuela S. Milani, Simone Muenst, Riccardo Murri, Charlotte K.Y. Ng, Stefan Nicolet, Patrick G.A. Pedrioli, Lucas Pelkmans, Salvatore Piscuoglio, Michael Prummer, Mathilde Ritter, Christian Rommel, María L. Rosano-González, Gunnar Rätsch, Natascha Santacroce, Jacobo Sarabia del Castillo, Ramona Schlenker, Petra C. Schwalie, Severin Schwan, Tobias Schär, Gabriela Senti, Franziska Singer, Sujana Sivapatham, Berend Snijder, Vipin T. Sreedharan, Stefan Stark, Daniel J. Stekhoven, Alexandre P.A. Theocharides, Tinu M. Thomas, Markus Tolnay, Vinko Tosevski, Nora C. Toussaint, Mustafa A. Tuncel, Marina Tusup, Audrey Van Drogen, Marcus Vetter, Tatjana Vlajnic, Sandra Weber, Walter P. Weber, Rebekka Wegmann, Michael Weller, Fabian Wendt, Norbert Wey, Andreas Wicki, Mattheus HE Wildschut, Bernd Wollscheid, Shuqing Yu, Johanna Ziegler, Marc Zimmermann, Martin Zoche, Gregor Zuend
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
CD8+ tumor-infiltrating T cells can be regarded as one of the most relevant predictive biomarkers in immune-oncology. Highly infiltrated tumors, referred to as inflamed (clinically “hot”), show the most favorable response to immune checkpoint inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d74ecfeeb15c1b4897606a94b52a648
Autor:
Marg, Andreas, Escobar, Helena, Karaiskos, Nikos, Grunwald, Stefanie A., Metzler, Eric, Kieshauer, Janine, Sauer, Sascha, Pasemann, Diana, Malfatti, Edoardo, Mompoint, Dominique, Quijano-Roy, Susanna, Boltengagen, Anastasiya, Schneider, Joanna, Schülke, Markus, Kunz, Séverine, Carlier, Robert, Birchmeier, Carmen, Amthor, Helge, Spuler, Andreas, Kocks, Christine, Rajewsky, Nikolaus, Spuler, Simone
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Skeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7, are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to utilize the regenerative potential of muscle stem cells for therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c3fc2f05d093cb4d5f6d5c0411430d0
http://edoc.mdc-berlin.de/18620/7/18620suppl.zip
http://edoc.mdc-berlin.de/18620/7/18620suppl.zip
Autor:
Ana Patiño-García, Thomas G. P. Grunewald, David G. Cox, Lindsay M. Morton, Michelle Manning, Sandrine Grossetête-Lalami, Gaëlle Pierron, Nadège Corradini, Stephen J. Chanock, Kathleen Wyatt, Udo Kontny, Gregory T. Armstrong, Jean Michon, Sakina Zaidi, Didier Surdez, Wolfgang Hartmann, Heinrich Kovar, Olivier Delattre, Jennifer Kriebel, Nathalie Gaspar, Perrine Marec Bérard, Valérie Laurence, Casey L. Dagnall, Thomas Kirchner, Stéphanie Reynaud, Uta Dirksen, Nathaniel Rothman, Konstantin Strauch, Margaret A. Tucker, Lisa Mirabello, Smita Bhatia, Markus Metzler, Laurie Burdett, Neal D. Freedman, Rebeca Alba Rubio, Franck Tirode, Andreas E. Kulozik, Meredith Yeager, Kristine Jones, Javier Alonso, Stelly Ballet, Olivier Mirabeau, Eve Lapouble, Robert N. Hoover, Weiyin Zhou, Wendy M. Leisenring, Leslie L. Robison, Piero Picci, Javed Khan, Thomas Meitinger, Anna González-Neira, Eric Karlins, Mitchell J. Machiela
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-05537-2⟩
Nat. Commun. 9:3184 (2018)
Nature Communications 9, 3184 (2018). doi:10.1038/s41467-018-05537-2
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-05537-2⟩
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-05537-2⟩
Nat. Commun. 9:3184 (2018)
Nature Communications 9, 3184 (2018). doi:10.1038/s41467-018-05537-2
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-05537-2⟩
Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusion. We performed a genome-wide association study of 733 EWS cases and 1346 unaffected individuals of European ancestry. Our study replicates previously reported susceptibil