Zobrazeno 1 - 10
of 2 181
pro vyhledávání: '"Kobayashi A"'
Autor:
Motohiro Izumi, Masanori Fujii, Ikei S. Kobayashi, Vivian Ho, Yukie Kashima, Hibiki Udagawa, Daniel B. Costa, Susumu S. Kobayashi
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-11 (2024)
Abstract In EGFR-mutated lung cancer, the duration of response to tyrosine kinase inhibitors (TKIs) is limited by the development of acquired drug resistance. Despite the crucial role played by apoptosis-related genes in tumor cell survival, how thei
Externí odkaz:
https://doaj.org/article/0b4880c0b7b44dc7aa9de281cdad4388
Autor:
Ryosuke Kobayashi, Yuki Tajika, Junki Kohmaru, Sumiyo Morita, Takuro Horii, Yoichi Mizukami, Shizu Aikawa, Yasushi Hirota, Izuho Hatada
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation requires dynamic remodeling of the endometrium through integrated proliferation and
Externí odkaz:
https://doaj.org/article/e712b2ec98b54d358ea32e9c927671eb
Autor:
Li Ma, Jiancheng Zhang, Yuko Fujita, Youge Qu, Jiajing Shan, Xiayun Wan, Xingming Wang, Tamaki Ishima, Kenta Kobayashi, Long Wang, Kenji Hashimoto
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Translational Psychiatry
Translational Psychiatry
(R, S)-ketamine has prophylactic antidepressant-like effects in rodents; however, the precise molecular mechanisms underlying its action remain unknown. Using RNA-sequencing analysis, we searched novel molecular target(s) that contribute to the proph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear.
Autor:
Hideki Arimochi, Shin-ichi Tsukumo, Hisanori Uehara, Yuki Sasaki, Thiranut Jaroonwitchawan, Kunihiro Otsuka, Tomoko Kobayashi, Koji Yasutomo, Michittra Boonchan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of
Autor:
Yoshiaki Maru, Makiko Enaka, Kentaro Fushimi, Akihiro Suzuki, Shingo Kato, Tomohiko Tamura, Takuma Higurashi, Noritoshi Kobayashi, Atsushi Nakajima, Yuichiro Yabuki, Yoshitaka Hippo, Daisuke Kurotaki, Sho Hasegawa, Masato Yoneda, Tetsuya Matsuura
Publikováno v:
Oncogenesis, Vol 10, Iss 4, Pp 1-13 (2021)
Oncogenesis
Oncogenesis
Genetically engineered mice (GEM) are the gold standard for cancer modeling. However, strict recapitulation of stepwise carcinogenesis from a single tumor-initiating epithelial cell among genetically intact cells in adults is not feasible with the cu
Autor:
Toshio Yamazaki, Nan Wu, Naohiro Kobayashi, Yutaka Kuroda, Kengo Tsuda, Satoru Unzai, Tomonori Saotome
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structur
Autor:
Sayaka Yoshimura, Toshiya Murai, Hironobu Fujiwara, Kei Kobayashi, Tsukasa Ueno, Takashi Miyagi, Naoya Oishi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Resilience is a dynamic process that enables organisms to cope with demanding environments. Resting-state functional MRI (fMRI) studies have demonstrated a negative correlation between resilience and functional connectivities (FCs) within the default
Autor:
Shoko Kobayashi, Kenjiro Ono, Toshitada Nagai, Kazuo Iwasa, Junji Komatsu, Moeko Noguchi-Shinohara, Kunihiko Yokoyama, Miharu Samuraki-Yokohama, Masahito Yamada, Hiroyuki Nakamura, Tsuyoshi Hamaguchi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
We conducted a randomized placebo-controlled double-blind 24-week trial using Melissa officinalis (M. officinalis) extract richly containing rosmarinic acid (RA) on patients with mild dementia due to Alzheimer’s disease (AD) with the aim to examine
Autor:
Aasa Shimizu, Tadashi Kimura, Masaki Kobayashi, Misa Yamamoto, Kyoso Ishida, Koji Nakamura, Akihiko Yoshimura, Kenjiro Sawada, Kae Hashimoto, Michiko Kodama, Mayuko Miyamoto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Paclitaxel resistance is a critical challenge in ovarian cancer treatment. This study aimed to identify microRNAs (miRNAs) that modulate paclitaxel resistance for use as potential therapeutic targets in such settings. Paclitaxel-resistant cell lines