Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alzheimer's Disease Neuroimaging Initiative"'
Autor:
Jing Tian, Kun Jia, Tienju Wang, Lan Guo, Zhenyu Xuan, Elias K. Michaelis, Russell H. Swerdlow, Alzheimer’s Disease Neuroimaging Initiative, Heng Du
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and genetic risks. Although the role of mitochondrial dysfun
Externí odkaz:
https://doaj.org/article/a34bda56f50e4eb085e3cf1b8b00de17
Autor:
Xue-Ning Shen, Yu-Yuan Huang, Shi-Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer’s diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed to evaluate whether it could serve as a marker for Alzheimer’s path
Externí odkaz:
https://doaj.org/article/ed93184db7324f0790dfe024c06363af
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The purpose of this study is to investigate the complex connection between apathy and cognitive decline that remains unclear. A total of 1057 non-dementia elderly from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database receive
Externí odkaz:
https://doaj.org/article/ed55588e207e42b0bdb584b3eb87abff
Autor:
Shi-Dong Chen, Yu-Yuan Huang, Xue-Ning Shen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract To assess plasma phosphorylated tau181 (p-tau181) as a progression biomarker in Alzheimer’s disease (AD), we examined longitudinal plasma p-tau181 of 1184 participants (403 cognitively normal (CN), 560 patients with mild cognitive impairme
Externí odkaz:
https://doaj.org/article/ff2a6ea7014a4fd5b6f449f29a1f71c1
Autor:
Qiang Dong, Shi-Dong Chen, Xue-Ning Shen, Yu-Yuan Huang, Yu Guo, Jin-Tai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry
Translational Psychiatry
To assess plasma phosphorylated tau181 (p-tau181) as a progression biomarker in Alzheimer’s disease (AD), we examined longitudinal plasma p-tau181 of 1184 participants (403 cognitively normal (CN), 560 patients with mild cognitive impairment (MCI),
Autor:
Alzheimer’s Disease Neuroimaging Initiative, Manolis Kellis, David A. Bennett, Alexander M. Kulminski, Liang He, Yury Loika, Yongjin Park
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Translational Psychiatry
Translational Psychiatry
Despite recent discoveries in genome-wide association studies (GWAS) of genomic variants associated with Alzheimer’s disease (AD), its underlying biological mechanisms are still elusive. The discovery of novel AD-associated genetic variants, partic
Autor:
Fu, A.K.Y., Kwok, T.C.Y., Mok, V.C.T., Ip, F.C., Sullivan, P.F., Mullapudi, N., Hardy, J., Chen, Y., Giusti-Rodríguez, P., Alzheimer's Disease Neuroimaging Initiative, Li, Y., Mok, K.Y., Ip, N.Y., Zhou, X., Guo, Q.
Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c310987845f11c7e3a8882db5fae5e
Autor:
Jung-Min Pyun, Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae-Won Jang, Jihwan You, Kwangsik Nho, SangYun Kim, the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Various plasma biomarkers for amyloid-β (Aβ) have shown high predictability of amyloid PET positivity. However, the characteristics of discordance between amyloid PET and plasma Aβ42/40 positivity are poorly understood. Thorough interpret
Externí odkaz:
https://doaj.org/article/c4261899c6e84d078775daff928aa6fa
Autor:
Caihua Wang, Hisateru Tachimori, Hiroyuki Yamaguchi, Atsushi Sekiguchi, Yuanzhong Li, Yuichi Yamashita, for Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Alzheimer’s disease is one of the most important health-care challenges in the world. For decades, numerous efforts have been made to develop therapeutics for Alzheimer’s disease, but most clinical trials have failed to show significant
Externí odkaz:
https://doaj.org/article/0c9ef0f7ea7540348a7fba545972910f
Autor:
Sarah Prieto, Kate E. Nolan, Jena N. Moody, Scott M. Hayes, Jasmeet P. Hayes, for the Department of Defense Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Chronic stress is a risk factor for dementia but whether it explains unique variance in cognitive decline in older adults above Alzheimer’s disease (AD) biomarkers is unknown. In a preclinical cohort of Vietnam Veterans, we examined the re
Externí odkaz:
https://doaj.org/article/86631bdfde1d49d9b8792cac082aec05