Zobrazeno 1 - 10
of 41
pro vyhledávání: '"A Laustsen"'
Autor:
Andreas Hougaard Laustsen, Manuela Berto Pucca, Christoffer V. Sørensen, Figen Caliskan, Rahel Janke, Line Ledsgaard, Erwin M. Schoof, Jonas A. Jürgensen, Shirin Ahmadi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Ahmadi, S, Pucca, M B, Jürgensen, J A, Janke, R, Ledsgaard, L, Schoof, E M, Sørensen, C V, Çalışkan, F & Laustsen, A H 2020, ' An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies ', Scientific Reports, vol. 10, no. 1, 10765 . https://doi.org/10.1038/s41598-020-67654-7
Scientific Reports
Ahmadi, S, Pucca, M B, Jürgensen, J A, Janke, R, Ledsgaard, L, Schoof, E M, Sørensen, C V, Çalışkan, F & Laustsen, A H 2020, ' An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies ', Scientific Reports, vol. 10, no. 1, 10765 . https://doi.org/10.1038/s41598-020-67654-7
Broadly-neutralizing monoclonal antibodies are of high therapeutic utility against infectious diseases caused by bacteria and viruses, as well as different types of intoxications. Snakebite envenoming is one such debilitating pathology, which is curr
Autor:
Lotte Bonde Bertelsen, Haiyun Qi, Per Mose Nielsen, Johan Palmfeldt, Mette Hadberg Løbner, Christoffer Laustsen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Laustsen, C, Nielsen, P M, Qi, H, Løbner, M H, Palmfeldt, J & Bertelsen, L B 2020, ' Hyperpolarized [1,4-13 C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy ', Scientific Reports, vol. 10, 9650 . https://doi.org/10.1038/s41598-020-66265-6
Laustsen, C, Nielsen, P M, Qi, H, Løbner, M H, Palmfeldt, J & Bertelsen, L B 2020, ' Hyperpolarized [1,4-13 C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy ', Scientific Reports, vol. 10, 9650 . https://doi.org/10.1038/s41598-020-66265-6
Today, there is a general lack of prognostic biomarkers for development of renal disease and in particular diabetic nephropathy. Increased glycolytic activity, lactate accumulation and altered mitochondrial oxygen utilization are hallmarks of diabeti
Autor:
Jakob Lindhardt, Nikolaj Bøgh, Robert S. Stephenson, Per Mose Nielsen, Peter Agger, Esben Søvsø Szocska Hansen, Camilla Omann, Vibeke E. Hjortdal, Christoffer Laustsen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Bøgh, N, Søvsø Szocska Hansen, E, Omann, C, Lindhardt, J L, Nielsen, P M, Stephenson, R S, Laustsen, C, Hjortdal, V E & Agger, P 2020, ' Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure ', Scientific Reports, vol. 10, 8158 . https://doi.org/10.1038/s41598-020-65098-7
Scientific Reports
Bøgh, N, Søvsø Szocska Hansen, E, Omann, C, Lindhardt, J L, Nielsen, P M, Stephenson, R S, Laustsen, C, Hjortdal, V E & Agger, P 2020, ' Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure ', Scientific Reports, vol. 10, 8158 . https://doi.org/10.1038/s41598-020-65098-7
In heart failure, myocardial overload causes vast metabolic changes that impair cardiac energy production and contribute to deterioration of contractile function. However, metabolic therapy is not used in heart failure care. We aimed to investigate t
Autor:
Daniel T. Griffiths, Edward W. Masters, Bruno Lomonte, Majken Lindholm, Saioa Oscoz, Rachael A. Leah, Aneesh Karatt-Vellatt, José María Gutiérrez, Ana Silvia Arias, Urska Pus, Alice M. Luther, John McCafferty, Peter Slavny, Andreas Hougaard Laustsen, Cecilie Knudsen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Laustsen, A H, Karatt-Vellatt, A, Masters, E W, Arias, A S, Pus, U, Knudsen, C, Oscoz, S, Slavny, P, Griffiths, D T, Luther, A M, Leah, R A, Lindholm, M, Lomonte, B, Gutiérrez, J M & McCafferty, J 2018, ' In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies ', Nature Communications, vol. 9, no. 1, 3928 . https://doi.org/10.1038/s41467-018-06086-4
Laustsen, A H, Karatt-Vellatt, A, Masters, E W, Arias, A S, Pus, U, Knudsen, C, Oscoz, S, Slavny, P, Griffiths, D T, Luther, A M, Leah, R A, Lindholm, M, Lomonte, B, Gutiérrez, J M & McCafferty, J 2018, ' In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies ', Nature Communications, vol. 9, no. 1, 3928 . https://doi.org/10.1038/s41467-018-06086-4
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Cur
Autor:
Matt Porteus, Niels Uldbjerg, Nadia R. Roan, L Kjær, Satish K. Pillai, Anders Laustsen, J H Egedahl, Paul W. Denton, Christian Krapp, Hai Q Tang, Martin R. Jakobsen, Rasmus O. Bak, Charlotte Christie Petersen, Mette Nyegaard
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Laustsen, A, Bak, R, Krapp, C, Kjær, L, Egedahl, J H, Petersen, C C, Pillai, S, Tang, H Q, Uldbjerg, N, Porteus, M, Roan, N R, Nyegaard, M, Denton, P W & Jakobsen, M R 2018, ' Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function ', Nature Communications, vol. 9, no. 1, 3525 . https://doi.org/10.1038/s41467-018-05816-y
Nature Communications
Laustsen, A, Bak, R, Krapp, C, Kjær, L, Egedahl, J H, Petersen, C C, Pillai, S, Tang, H Q, Uldbjerg, N, Porteus, M, Roan, N R, Nyegaard, M, Denton, P W & Jakobsen, M R 2018, ' Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function ', Nature Communications, vol. 9, no. 1, 3525 . https://doi.org/10.1038/s41467-018-05816-y
Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34+ hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited inductio
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