Zobrazeno 61 - 70
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pro vyhledávání: ''
Autor:
Kariena R. Andres, Eric C. Rouchka, Sujata Saraswat Ohri, Scott R. Whittemore, Julia H. Chariker, Scott A. Myers, Michal Hetman, Molly V. Parsh, Lukasz P. Slomnicki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
The transcription factor BMAL1/ARNTL is a non-redundant component of the clock pathway that regulates circadian oscillations of gene expression. Loss of BMAL1 perturbs organismal homeostasis and usually exacerbates pathological responses to many type
Autor:
Jungwan Hong, Dongyeong Yoon, Youngpyo Nam, Tae Yong Lee, Kyoungho Suk, Kyung Suk Kim, Min Sung Kim, Sang Ryong Kim, Jong-Heon Kim, Ho-Won Lee, Pan-Woo Ko, Donggun Seo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Most cerebellar ataxias (CAs) are incurable neurological disorders, resulting in a lack of voluntary control by inflamed or damaged cerebellum. Although CA can be either directly or indirectly related to cerebellar inflammation, there is no suitable
Autor:
Nian Liu, Pingping Zhu, Yong Tian, Liuliu Yang, Zusen Fan, Buqing Ye, L.L. He, H.B. Li, Benyu Liu, Tiankun Lu, Xiaoxiao Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that is
Autor:
Jan L. Breslow, David Danko, Simone Zuffa, Christopher E. Mason, Sandra Garcet, Jose O. Aleman, Peter R. Holt, James G. Krueger, Jeanne M. Walker, Jonathan R. Swann
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Obesity is accompanied by dysfunction of many organs, but effects on the skin have received little attention. We studied differences in epithelial thickness by histology and gene expression by Affymetrix gene arrays and PCR in the skin of 10 obese (B
Autor:
Michelle Warren Millar, Fabeha Fazal, Arshad Rahman, Antony Leonard, Mohammad Shadab, Spencer A. Slavin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Endothelial cell (EC) inflammation and permeability are critical pathogenic mechanisms in many inflammatory conditions including acute lung injury. In this study, we investigated the role of ATG7, an essential autophagy regulator with no autophagy-un
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Ulcerative colitis (UC) is one of the most common forms of inflammatory bowel disease (IBD) characterized by inflammation of the mucosal layer of the colon. Diagnosis of UC is based on clinical symptoms, and then confirmed based on endoscopic, histol
Autor:
Jeong-a Kim, Qinglin Yang, Sushant Bhatnagar, Hae-Suk Kim, Teayoun Kim, Young Yil Bahk, Guang Ren
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Autophagy, an integral part of the waste recycling process, plays an important role in cellular physiology and pathophysiology. Impaired autophagic flux causes ectopic lipid deposition, which is defined as the accumulation of lipids in non-adipose ti
Autor:
Asaf Spiegel, Hassan Massalha, Shalev Itzkovitz, Orit Kollet, Eman Khatib-Massalha, Isabell Brandenburger, Suditi Bhattacharya, Francesca Avemaria, Ronen Alon, Ziv Shulman, Zachary Gerhart-Hines, Amiram Ariel, Tsvee Lapidot, Tomer Itkin, Adi Biram, Karin Golan, Ekaterina Petrovich-Kopitman, Anju Kumari, Stefan Offermanns, Matthias Gunzer, Shiri Gur-Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neut
Autor:
Charlotte Hansen, Marcus Altfeld, Claudia Marggraff, Jill Noll, Stefan Hoenow, Iris Bruchhaus, Nahla Galal Metwally, Marie Weskamm, Marie Groneberg, Christoph Dorn, Stephanie Stanelle-Bertram, Svenja Kuehl, Harald Ittrich, Thomas Jacobs, Sven Hendrik Hagen, Julie Sellau, Egbert Tannich, Julia Wernecke, Vincent Wolf, Helena Fehling, Thorsten Thye, Hannelore Lotter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of
Autor:
Chang Ho Song, Dong-Uk Shin, Yan Jing Fan, Hyeon-Ji Song, Chun Hua Piao, Seung Yong Kim, Hee Soon Shin, Thi Van Nguyen, Ok Hee Chai
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
An ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model was established to investigate whether α-Lipoic acid (LA) has a protective effect against upper respiratory tract inflammation. BALB/c mice were sensitized by intraperitoneal injection an