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Autor:
Vanessa Bastos Pereira, Tatiane Melo Preisser, Denise Carmona Cara Machado, Vanessa Pecini da Cunha, Mariana Passos Santana, Anderson Miyoshi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Intestinal fibrosis associated with Crohn’s disease (CD), which a common and serious complication of inflammatory bowel diseases. In this context, heat shock proteins (HSPs) might serve as an alternative treatment because these antigens play import
Autor:
José María Zapico, Gonzalo Herradón, Esther Gramage, M. Pilar Ramos-Alvarez, Marta Vicente-Rodríguez, Milagros Galán-Llario, María Uribarri, Rosalía Fernández-Calle, Marcel Ferrer-Alcón, Begoña Zapatería, Beatriz de Pascual-Teresa, Ana Ramos
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels i
Autor:
Tsung Wen Chong, June Jingyi Tai, Shazib Pervaiz, Siew Cheng Wong, Gregory Lucien Bellot, Binbin Wang, Herbert Schwarz, Kartini Iskandar, Fera Yiqian Goh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Sepsis is a potentially fatal condition triggered by systemic inflammatory response to infection. Due to the heightened immune reactivity and multi-organ pathology, treatment options are limited and several clinical trials have not produced the desir
Autor:
Jaemyoung Sung, Takenori Inomata, Yuichi Okumura, Kenta Fujio, Jun Zhu, Akira Murakami, Naoko Negishi, Toshinari Funaki, Hurramhon Shokirova, Mikiko Okano, Maria Miura, Keiichi Fujimoto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Corneal allograft survival is mediated by the variety of immunological reactions and wound healing process. Our aim was to explore the effects of topical administration of ripasudil, a selective Rho-associated coiled-coil protein kinase inhibitor, on
Autor:
Yan-Hong Li, Bin-Bin Fang, Xiao-Mei Li, Xiao-Ming Gao, Fen Liu, Jun-Yi Luo, Ting Tian, Yi-Ning Yang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Myocardial infarction (MI), the leading cause of mortality and disability worldwide, is a disease in which multiple environmental and genetic factors are involved. Recently, researches suggested that insertion/deletion (ins/del) variation of NFKB1 ge
Autor:
Hanne Vanheel, Tim Vanuytsel, Silvia Cocca, Guy E. Boeckxstaens, Ricard Farré, Alison Accarie, Dorien Beeckmans, Gianluca Matteoli, Hans-Reimer Rodewald, María Vicario, Joran Toth, Jan Tack, Lucas Wauters, Gert De Hertogh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports
Duodenal hyperpermeability and low-grade inflammation in functional dyspepsia is potentially related to duodenal acid exposure. We aimed to evaluate in healthy volunteers the involvement of mast cell activation on the duodenogastric reflex and epithe
Autor:
Monika Niewiadomska, Lynsie Morris, Samantha Stansbury, Lyndee Branen, Avery Melton, Angela Herron, Raisa Monteiro, Khaled Elkholey, Mahesh Kumar Sivasubramanian, Priya Balasubramanian, Stavros Stavrakis, Madhan Subramanian, Laura Edwards
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
The anti-inflammatory effects of vagus nerve stimulation are well known. It has recently been shown that low-level, transcutaneous stimulation of vagus nerve at the tragus (LLTS) reduces cardiac inflammation in a rat model of heart failure with prese
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Bovine tuberculosis (bTB), a zoonosis mainly caused by Mycobacterium bovis has severe socio-economic consequences and impact on animal health. Host–pathogen interactions during M. bovis infection are poorly understood, especially early events which
Autor:
Samar Imbaby, Hiroki Yokoo, Yuichi Hattori, Kohshi Hattori, Naoyuki Matsuda, Sailesh Palikhe, Kengo Tomita
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Sepsis is a major clinical challenge with unacceptably high mortality. The signal transducers and activators of transcription (STAT) family of transcription factors is known to activate critical mediators of cytokine responses, and, among this family
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
There are a number of respiratory diseases characterized by the presence of excess neutrophil elastase (NE) activity in tissues, including cystic fibrosis and chronic obstructive pulmonary disease (COPD). NE is considered a primary contributor to dis