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Autor:
Tsung Wen Chong, June Jingyi Tai, Shazib Pervaiz, Siew Cheng Wong, Gregory Lucien Bellot, Binbin Wang, Herbert Schwarz, Kartini Iskandar, Fera Yiqian Goh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Sepsis is a potentially fatal condition triggered by systemic inflammatory response to infection. Due to the heightened immune reactivity and multi-organ pathology, treatment options are limited and several clinical trials have not produced the desir
Autor:
Nan Wu, Chunfang Liu, Hong Ji, Ruolin Mao, Yuzhen Zeng, Zhilong Jiang, Zhihong Chen, Juan Song, Zhihui Min, Kan Xu, Zheng Li, Tao Zhu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Airway dendritic cells (DCs) are recognized as important factors in the mechanisms of allergic inflammatory diseases. Suppressor of cytokine signaling 3 (SOCS3) is involved in regulating the functions of T cells and macrophages, but the roles of SOCS
Autor:
Sergei P. Atamas, Patrick Geraghty, Pratap Karki, Nevins W. Todd, Konstantin G. Birukov, Irina G. Luzina, Anne E. Wyman, Trang T. T. Nguyen, Abdoulaye J. Dabo, Theresa G. Feng, Robert F. Foronjy, Anna A. Birukova, Chen-Ou Zhang, Junghyun Kim, Jeffrey D. Hasday, Mohan E. Tulapurkar
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Acute lung injury (ALI), a common condition in critically ill patients, has limited treatments and high mortality. Aging is a risk factor for ALI. Sirtuins (SIRTs), central regulators of the aging process, decrease during normal aging and in aging-re
Autor:
Guohui Li, Da-Cheng Wang, Siying Qin, Kai Zhang, Can Xie, Hang Yin, Fei Sun, Yukun Guan, Run Fang, Honglei Wang, Fangwei Leng, Zhengfan Jiang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
NOD-like receptors (NLRs) localize in the cytosol to recognize intracellular pathogen products and initialize the innate immune response. However, the ligands and ligand specificity of many NLRs remain unclear. One such NLR, NLRP6, plays an important
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Sepsis is typically triggered by an overwhelming systemic inflammatory response to pathogens, and may lead to severe organ dysfunction and/or death. Sepsis consequently has a high mortality rate and a high rate of complications for survivors, despite
Autor:
Sungyong You, Min Young Lee, Muhammad Shahid, Luis Valdiviez, Jayoung Kim, Eunho Cho, Austin Yeon, Vikram Sairam
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Chronic inflammation is a potential systemic risk factor for many bladder dysfunctions, including interstitial cystitis (IC). However, the underlying mechanism through which a healthy bladder protects itself from inflammatory triggers remains unknown
Autor:
Sok Lin Foo, Lina H. K. Lim, Anna-Marie Fairhurst, Tong Gu, Leonardo A. Moraes, Karishma Sachaphibulkij, Yi Qian Toh, Alan Prem Kumar, Hakim M. Lukman, Shreya Kar, Gracemary Yap, Olga Zharkova, Patrick B. Ampomah
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Macrophages are potent immune cells with well-established roles in the response to stress, injury, infection and inflammation. The classically activated macrophages (M1) are induced by lipopolysaccharide (LPS) and express a wide range of pro-inflamma
Autor:
Yuji Ogawa, Yoshio Sumida, Yoshito Itoh, Shingo Kato, Wataru Tomeno, Yasushi Honda, Takaomi Kessoku, Takeharu Yamanaka, Hideyuki Hyogo, Koji Fujita, Satoru Saito, Atsushi Nakajima, Kosei Eguchi, Yusuke Saigusa, Kento Imajo, Masato Yoneda, Koichiro Wada
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Although previous studies have indicated important roles of palmitate, a saturated fatty acid, in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), it remains unclear how palmitate contributes to inflammation and fibrosis in the liver. Ad