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Akademický článek
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Autor:
Zhenfei Bi, Weiqi Hong, Haiying Que, Cai He, Wenyan Ren, Jingyun Yang, Tianqi Lu, Li Chen, Shuaiyao Lu, Xiaozhong Peng, Xiawei Wei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The development of animal models for COVID-19 is essential for basic research and drug/vaccine screening. Previously reported COVID-19 animal models need to be established under a high biosafety level condition for the utilization of live SARS-CoV-2,
Autor:
Tong Dai, Bin Wang, Linghui Zeng, Fangfang Zhou, Lei Zhang, Long Zhang, Yetian Dong, Jun Huang, Haiyan Yan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-14 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rol
Autor:
Xiuying Li, Tiao Li, Seyed Mehdi Nouraie, Janet S. Lee, Kong Chen, Georgios D Kitsios, Rama K. Mallampalli, Bryan J. McVerry, Yingze Zhang, Yandong Lai, Chunbin Zou, Toru Nyunoya
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Lung epithelial cell death is a prominent feature of acute lung injury and acute respiratory distress syndrome (ALI/ARDS), which results from severe pulmonary infection leading to respiratory failure. Multiple mechanisms are believed to contribute to
Akademický článek
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Autor:
Zhenwei Xia, Zhihan Wang, Shugang Qin, Ping Lin, Pan Gao, Min Wu, Nadeem Khan, Colin K. Combs, Kai Guo, Qinqin Pu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-10 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Bitter receptors function primarily in sensing taste, but may also have other functions, such as detecting pathogenic organisms due to their agile response to foreign objects. The mouse taste receptor type-2 member 138 (TAS2R138) is a member of the G
Autor:
Siwen Zhao, Jingmei Li, Xingli Qian, Haixuan Wang, Wenhai Yu, Xiaozhong Peng, Dexuan Kuang, Bin Yin, Longjiang Xu, Kaiyun Ding, Jiahong Gao, Junbin Wang, Haiting Long, Li Jiao, Shuaiyao Lu, Haiyan Li, Jingwen Xu, Mengli Yang, Fangyu Luo, Yun Yang, Wei Liu, Hongqi Liu, Jing Yang, Yuan Zhao, Chunxia Ma
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of C
Autor:
Jin-Kui Yang, Li Zhang, Youchun Wang, Fang-Yuan Yang, Wei Hou, Yingmei Feng, Changfa Fan, Wei-Li Yang, Rong-Hua Jin, Miao-Miao Zhao, Weijin Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SUMMARYTo discover new drugs to combat coronavirus disease 2019 (COVID-19), an understanding of the molecular basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is urgently needed. Here, for the first time, we report the
Akademický článek
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