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pro vyhledávání: ''
Autor:
Patrick M Noone, Masayuki Yamamoto, Haranatha R. Potteti, Thomas W. Kensler, Narsa M. Reddy, Chandra Mohan Tamatam, Aparna Ankireddy, Sekhar P. Reddy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Bronchopulmonary dysplasia (BPD) is a chronic disease of preterm babies with poor clinical outcomes. Nrf2 transcription factor is crucial for cytoprotective response, whereas Keap1—an endogenous inhibitor of Nrf2 signaling—dampens these protectiv
Autor:
Michelle Warren Millar, Fabeha Fazal, Arshad Rahman, Antony Leonard, Mohammad Shadab, Spencer A. Slavin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Endothelial cell (EC) inflammation and permeability are critical pathogenic mechanisms in many inflammatory conditions including acute lung injury. In this study, we investigated the role of ATG7, an essential autophagy regulator with no autophagy-un
Autor:
Sergei P. Atamas, Patrick Geraghty, Pratap Karki, Nevins W. Todd, Konstantin G. Birukov, Irina G. Luzina, Anne E. Wyman, Trang T. T. Nguyen, Abdoulaye J. Dabo, Theresa G. Feng, Robert F. Foronjy, Anna A. Birukova, Chen-Ou Zhang, Junghyun Kim, Jeffrey D. Hasday, Mohan E. Tulapurkar
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Acute lung injury (ALI), a common condition in critically ill patients, has limited treatments and high mortality. Aging is a risk factor for ALI. Sirtuins (SIRTs), central regulators of the aging process, decrease during normal aging and in aging-re
Autor:
Ritsumi Saito, Teiji Tominaga, Masayuki Yamamoto, Daisuke Saigusa, Takahiro Yamazaki, Yoshihisa Tomioka, Akira Uruno, Yotaro Matsumoto, Sherif Rashad, Kuniyasu Niizuma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Understanding the root causes of neuronal vulnerability to ischemia is paramount to the development of new therapies for stroke. Transient global cerebral ischemia (tGCI) leads to selective neuronal cell death in the CA1 sub-region of the hippocampus
Autor:
Benito A. Yard, Carolina De La Torre, Nicolas Krapp, Anna-Isabelle Kälsch, Bernhard K. Krämer, Marloes Sol, M Kolibabka, Prama Pallavi, Björn B. Hofmann, Jana D. Braun, Yingchun Li
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, 9:19338. Nature Publishing Group
Scientific Reports
Scientific Reports, 9:19338. Nature Publishing Group
Scientific Reports
IFNγ enhances allograft immunogenicity and facilitates T-cell mediated rejection. This may cause interstitial fibrosis and tubular atrophy (IFTA), contributing to chronic allograft loss. We assessed if inhibition of T-cell activation by N-octanoyl d
Autor:
David Bryder, Isabella Artner, Rashmi B. Prasad, Luis Sarmiento, Malin Fex, Ewa Sitnicka, Monika Dudenhöffer-Pfeifer, Luis Rodrigo Cataldo, P. Chaves, Tania Singh, Lisbeth Hansen, Sara Bsharat, Corrado M. Cilio, Jesper K. Colberg, Dan Holmberg
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Maf transcription factors are critical regulators of beta-cell function. We have previously shown that reduced MafA expression in human and mouse islets is associated with a pro-inflammatory gene signature. Here, we investigate if the loss of Maf tra
Autor:
AlAsfoor, Shefaa, Rohm, Theresa V., Bosch, Angela J. T., Dervos, Thomas, Calabrese, Diego, Matter, Matthias S., Weber, Achim, Cavelti-Weder, Claudia
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Macrophages have been recognized as key players in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether pharmacological attenuation of macrophages can be achieved by imatinib, an anti-leukemia drug with known anti-inflammatory and
Autor:
Marco C. J. M. Kelders, Annemie M. W. J. Schols, C. C. de Theije, Anita Kneppers, Mitja Lainscak, Harry R. Gosker, Pieter A. Leermakers
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports, 8:15007. Nature Publishing Group
Scientific Reports
Scientific Reports, 8:15007. Nature Publishing Group
Loss of skeletal muscle mitochondrial oxidative capacity is well-established in patients with COPD, but the role of mitochondrial breakdown herein is largely unexplored. Currently, we studied if mitochondrial breakdown signalling is increased in skel
Autor:
Francisco Ruiz-Marcos, Julia González-Gómez, Victoriano Baladrón, María Luisa Nueda, María José Romero de Ávila, Isabella Screpanti, María José Díaz-Guerra, Maria Pia Felli, Natalia Carolina Hernández de León, Jorge Laborda, José J. García-Ramírez, Susana López-López, Eva M. Monsalve, María J. García-León
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
instname
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Macrophage activation by Toll receptors is an essential event in the development of the response against pathogens. NOTCH signaling pathway is involved in the control of macrophage activation and the inflammatory processes. In this work, we have char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bcfee6462b55b07970a3c9d4831d7d
http://hdl.handle.net/10261/237976
http://hdl.handle.net/10261/237976
Autor:
Jie Zhou, Charles N. Rotimi, Adebowale Adeyemo, Amadou Gaye, Gary H. Gibbons, Ayo P. Doumatey, Lin Lei, William J. He
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Obese individuals without expected metabolic co-morbidities are referred to as metabolically healthy obese (MHO). The molecular mechanisms underlying this phenotype remain elusive. MicroRNAs may be involved in the MHO phenotype. To test this hypothes