Zobrazeno 61 - 70
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Autor:
Lolita Ott, Stefan Schrader, Joana Witt, Jana Dietrich, Gerd Geerling, Sonja Mertsch, M. Roth
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Dry eye disease (DED) is a multifactorial disease characterized by a disrupted tear film homeostasis and inflammation leading to visual impairments and pain in patients. Aqueous-deficient dry eye (ADDE) causes the most severe progressions and depends
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
In cancer patients, a high pre-treatment neutrophil-to-lymphocyte ratio (NLR) is associated with poorer survival outcomes. Significant variation in the magnitude of this association has been observed between studies, but sources of this variation are
Autor:
Jeljeli, Mohamed, Riccio, Luiza Gama Coelho, Doridot, Ludivine, Chêne, Charlotte, Nicco, Carole, Chouzenoux, Sandrine, Deletang, Quentin, Allanore, Yannick, Kavian, Niloufar, Batteux, Frédéric
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or low
Autor:
Megan Cullen, Brian C. Gilger, Jacquelyn J. Bower, Telmo Llanga, Elizabeth Crabtree, Jacklyn H. Salmon, Liujiang Song, Matthew L. Hirsch
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Non-infectious uveitis (NIU) is an intractable, recurrent, and painful disease that is a common cause of vision loss. Available treatments of NIU, such as the use of topical corticosteroids, are non-specific and have serious side effects which limits
Autor:
Uma S. Sajjan, Sudhir Kotnala, Joao Gimenes-Junior, Wuyan Li, Nathaniel Xander, Hymavathi Reddy Vari, Nicole Owuar
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Forkhead transcription factor class O (FOXO)3a, which plays a critical role in a wide variety of cellular processes, was also found to regulate cell-type-specific antiviral responses. Airway epithelial cells express FOXO3a and play an important role
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
The epithelial-to-mesenchymal transition (EMT) is an essential developmental process which can be hijacked by cancer cells, leading to enhanced metastasis and chemoresistance in experimental models. Recent studies have linked gene expression of EMT-a
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Two distinct p38 signaling pathways, classical and alternative, have been identified to regulate inflammatory responses in host defense and disease development. The role of alternative p38 activation in liver inflammation is elusive, while classical
Autor:
Pascal O. Bessong, Zulfiqar A Bhutta, Richard L. Guerrant, Sadia Shakoor, James A Platts-Mills, Ahshanul Haque, Ashraful Alam, Gagandeep Kang, Tahmeed Ahmed, Alexandre Havt, Dennis Lang, Estomih Mduma, Sanjaya K. Shrestha, Aldo A. M. Lima, Mustafa Mahfuz, Amidou Samie, Eric R. Houpt, Ladaporn Bodhidatta, Margaret Kosek
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of thi
Autor:
Jim Petrik, Michael G. Surette, Deborah M. Sloboda, Erica Yeo, Yu Fei Xia, Dawn M. E. Bowdish, Christian J. Bellissimo, Jessica G. Wallace
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports
We investigated whether diet-induced changes in the maternal intestinal microbiota were associated with changes in bacterial metabolites and their receptors, intestinal inflammation, and placental inflammation at mid-gestation (E14.5) in female mice
Autor:
Bin Yoo, Tae-Hwan Kim, Yong-Gil Kim, Jeehee Youn, Eunju Lee, Seokchan Hong, Chang-Keun Lee, Doo-Ho Lim, Oh Chan Kwon
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
To prevent spinal progression in ankylosing spondylitis, initiating TNF-inhibitor treatment as early as possible is suggested. However, the outcomes are inconsistent in previous clinical studies. Here, we investigated the effect of TNF inhibition alo