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Autor:
Zhirong Liu, Zheyu Li, Shuai Zhao, Baorong Zhang, Ziqi Fan, Yueli Zhu, Yanxing Chen, Kaicheng Li, Jing Hu, Ting Shen, Caixiu Lin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Previous research has shown that exposure to volatile anesthetics can induce acute neuroinflammation and neuroapoptopsis in neonatal rodents and that these events can lead to cognitive dysfunction at later stages. Isoflurane and sevoflurane are two o
Autor:
Derek Adler, Shavonne Teng, Sahithi Reddi, D.S. Berger, Patrick Sullivan, Smita Thakker-Varia, Cynthia Zheng, Anna O. Giarratana, Janet Alder
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
After traumatic brain injury (TBI), some people have worse recovery than others. Single nucleotide polymorphisms (SNPs) in Apolipoprotein E (APOE) are known to increase risk for developing Alzheimer’s disease, however there is controversy from huma
Autor:
Vogel, Alexandra, Wilken-Schmitz, Annett, Hummel, Regina, Lang, Manuel, Gurke, Robert, Schreiber, Yannick, Schäfer, Michael K. E., Tegeder, Irmgard
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-22 (2020)
Scientific Reports
Scientific Reports
Traumatic brain injury (TBI) is a frequent cause of chronic headache, fatigue, insomnia, hyperactivity, memory deficits, irritability and posttraumatic stress disorder. Recent evidence suggests beneficial effects of pro-cannabinoid treatments. We ass
Autor:
Yi Zou, Zhao Lai, Dawn Garcia, Theodore J. Price, Jennifer Mecklenburg, Gregory Dussor, Armen N. Akopian, Alexei V. Tumanov, Andi Wangzhou
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Many chronic pain conditions show sex differences in their epidemiology. This could be attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive pathways, including sensory neurons. This study aimed to identify sex-d
Autor:
Wei Xia, Xue Yin, Xue-fei Zhu, Bingyu Zhang, Weiming Liu, Peirong Lu, Chi Ren, Lei Chen, Gaoqin Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Wet age-related macular degeneration (AMD), which can cause progressive blindness, is characterised by choroid neovascularization (CNV) in the macular area. Although close attention has been paid to AMD, and anti-vascular endothelial growth factor (V
Autor:
Evi Paouri, Nikoleta Kalovyrna, Sotiria Boulekou, Athena Boutou, Spiros Georgopoulos, Olympia Apokotou
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine, involved in Alzheimer’s disease pathogenesis. Anti-TNF-α therapeutic approaches currently used in autoimmune diseases have been proposed as a therapeutic strategy in AD. We have pre
Autor:
Aldrin V. Gomes, Brett S. Phinney, Joanne L. Newens, Michelle Salemi, Shuchita Tiwari, Manish Mishra
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, r
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulates gut microbes, and dephosphorylates proinflammatory nucleotides. IAP also exhibits anti-inflammatory effects in a Toll-like Receptor-
Autor:
Lolita Ott, Stefan Schrader, Joana Witt, Jana Dietrich, Gerd Geerling, Sonja Mertsch, M. Roth
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Dry eye disease (DED) is a multifactorial disease characterized by a disrupted tear film homeostasis and inflammation leading to visual impairments and pain in patients. Aqueous-deficient dry eye (ADDE) causes the most severe progressions and depends
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Two distinct p38 signaling pathways, classical and alternative, have been identified to regulate inflammatory responses in host defense and disease development. The role of alternative p38 activation in liver inflammation is elusive, while classical