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Autor:
Thiago C. Genaro-Mattos, Allison Anderson, Zeljka Korade, Luke B. Allen, Keri A. Tallman, Ned A. Porter, Karoly Mirnics
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholesterol (7-DH
Autor:
Etienne Challet, Hicham Farsi, Khalid El Allali, Mohamed Rachid Achaâban, Paul Pévet, Mohammed Piro, Mohammed Ouassat, Béatrice Bothorel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-76535-y⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-76535-y⟩
In the dromedary camel, a well-adapted desert mammal, daily ambient temperature (Ta)-cycles have been shown to synchronize the central circadian clock. Such entrainment has been demonstrated by examining two circadian outputs, body temperature and me
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
The glucocorticoid stress response is frequently used to indicate vertebrate response to the environment. Body temperature may affect glucocorticoid concentrations, particularly in ectotherms. We conducted lab manipulations and field measurements to
Autor:
Douglas G. McMahon, Chad R. Jackson, Pat Levitt, Justin K. Siemann, Turnee N Malik, Noah H. Green, Ronald B. Emeson, Piper Williams
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Photoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we eval
Autor:
Yuxi Li, Jung-Chien Cheng, Sijia Wang, Zhen Wang, Xiaoyu Han, Yiran Li, Yingpu Sun, Yang Yan, Lanlan Fang, Ze Wu, Qiongqiong Jia
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1341-1350 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment. Although the pathogenesis of OHS
Autor:
Elisa N. Cannon, Joseph Biederman, Deirdre M. McCarthy, Pradeep G. Bhide, Thomas J. Morgan, Thomas J. Spencer, Sarah E. Lowe
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The use of non-nutritive sweeteners such as saccharin is widely prevalent. Although saccharin is considered safe for human consumption, it produces behavioral changes in experimental animals. We report that saccharin’s behavioral effects are much m
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Medaka (Oryzias latipes) is a teleost fish with an XX/XY sex determination system, similar to that of mammals. However, under high temperature conditions, XX medaka is masculinised by elevation of cortisol, the major teleost glucocorticoid. In this s
Autor:
Ghadeer K. Dawwas, Warren B. Bilker, Samantha E. Soprano, Joshua J. Gagne, Charles E. Leonard, Sean Hennessy, James H. Flory, Colleen M. Brensinger, Neil Dhopeshwarkar
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Sulfonylureas are commonly used to treat type 2 diabetes mellitus. Despite awareness of their effects on cardiac physiology, a knowledge gap exists regarding their effects on cardiovascular events in real-world populations. Prior studies reported sul
Autor:
Kushal Kapse, Adre J. du Plessis, Taeun Chang, Mariam Said, Subechhya Pradhan, Matthew T. Whitehead, Jonathan Murnick, Sudeepta K Basu, Catherine Limperopoulos, Marni B. Jacobs
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Gamma-aminobutyric acid (GABA) and glutamate are principal neurotransmitters essential for late gestational brain development and may play an important role in prematurity-related brain injury. In vivo investigation of GABA in the preterm infant with
Autor:
Jeanie B. Tryggestad, April M. Teague, Shaoning Jiang, Mary Ellen Jensen, Steven D. Chernausek
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain