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pro vyhledávání: ''
Autor:
Vanessa Bastos Pereira, Tatiane Melo Preisser, Denise Carmona Cara Machado, Vanessa Pecini da Cunha, Mariana Passos Santana, Anderson Miyoshi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Intestinal fibrosis associated with Crohn’s disease (CD), which a common and serious complication of inflammatory bowel diseases. In this context, heat shock proteins (HSPs) might serve as an alternative treatment because these antigens play import
Autor:
Tsung Wen Chong, June Jingyi Tai, Shazib Pervaiz, Siew Cheng Wong, Gregory Lucien Bellot, Binbin Wang, Herbert Schwarz, Kartini Iskandar, Fera Yiqian Goh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Sepsis is a potentially fatal condition triggered by systemic inflammatory response to infection. Due to the heightened immune reactivity and multi-organ pathology, treatment options are limited and several clinical trials have not produced the desir
Autor:
Derek Adler, Shavonne Teng, Sahithi Reddi, D.S. Berger, Patrick Sullivan, Smita Thakker-Varia, Cynthia Zheng, Anna O. Giarratana, Janet Alder
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
After traumatic brain injury (TBI), some people have worse recovery than others. Single nucleotide polymorphisms (SNPs) in Apolipoprotein E (APOE) are known to increase risk for developing Alzheimer’s disease, however there is controversy from huma
Autor:
Patrick M Noone, Masayuki Yamamoto, Haranatha R. Potteti, Thomas W. Kensler, Narsa M. Reddy, Chandra Mohan Tamatam, Aparna Ankireddy, Sekhar P. Reddy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Bronchopulmonary dysplasia (BPD) is a chronic disease of preterm babies with poor clinical outcomes. Nrf2 transcription factor is crucial for cytoprotective response, whereas Keap1—an endogenous inhibitor of Nrf2 signaling—dampens these protectiv
Autor:
Masafumi Matsuo, Takashi Matsuwaki, Keitaro Yamanouchi, Takanori Shiga, Hidetoshi Sugihara, Ichizo Nishino, Naomi Teramoto, Taku Shirakawa, Masashi Ogasawara, Katsuyuki Nakamura, Masugi Nishihara
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Duchenne muscular dystrophy (DMD) is a progressive disease characterised by chronic muscle degeneration and inflammation. Our previously established DMD model rats (DMD rats) have a more severe disease phenotype than the broadly used mouse model. We
Autor:
Amin Marghalani, Wael Yaghmoor, Isabel Carreras, Jae-Yong Ahn, Christina M. Tognoni, Danielle Stephens, Alpaslan Dedeoglu, Alpdogan Kantarci
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Periodontal disease (PD) has been suggested to be a risk factor for Alzheimer’s disease (AD). We tested the impact of ligature-induced PD on 5xFAD mice and WT littermates. At baseline, 5xFAD mice presented significant alveolar bone loss compared to
Autor:
Kiyoko Fukami, Kengo Totoki, Yoshikazu Nakamura, Keisuke Nakase, Karen Nakamura, Kaori Kanemaru, Madoka Shoji, Norihisa Noguchi, Hidemasa Nakaminami
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Staphylococcus aureus (S. aureus) commonly colonizes the human skin and nostrils. However, it is also associated with a wide variety of diseases. S. aureus is frequently isolated from the skin of patients with atopic dermatitis (AD), and is linked to
Autor:
Watcharamat Muangkaew, Kanchana Kengkoom, Passanesh Sukphopetch, Sumate Ampawong, Tapanee Kanjanapruthipong, Theerapong Buaban, Pornanong Aramwit
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Psoriasis is mainly caused because of inappropriate immune responses in the epidermis. Rice (Oryza sativa L.: SRNC05053-6-2) consists of anthocyanin, which exhibits strong antioxidative and anti-inflammatory properties. This study aimed to evaluate t
Autor:
Harshal Hanumant Nandurkar, Melrine Pereira, Carly Selan, Natasha Ting Lee, David W. Wright, Akram Zamani, Maithili Sashindranath, Sharelle Anne Sturgeon, Joanne S. J. Chia
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Stroke is caused by obstructed blood flow (ischaemia) or unrestricted bleeding in the brain (haemorrhage). Global brain ischaemia occurs after restricted cerebral blood flow e.g. during cardiac arrest. Following ischaemic injury, restoration of blood
Autor:
Samar Imbaby, Hiroki Yokoo, Yuichi Hattori, Kohshi Hattori, Naoyuki Matsuda, Sailesh Palikhe, Kengo Tomita
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Sepsis is a major clinical challenge with unacceptably high mortality. The signal transducers and activators of transcription (STAT) family of transcription factors is known to activate critical mediators of cytokine responses, and, among this family