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Autor:
Costantino Pitzalis, Esteban A. Gomez, Conrad Bessant, Romain A. Colas, Rebecca Hands, Myles Lewis, Patricia R. Souza, Jesmond Dalli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral
Autor:
David H. Ebb, Cassandra Garbutt, Christopher E. Lietz, Brian Lawney, Vikram Deshpande, Zhenfeng Duan, Yen-Lin Chen, Francis J. Hornicek, Dimitrios Spentzos, Santiago A. Lozano-Calderon, G. Petur Nielsen, Benjamin Haibe-Kains, Gregory M. Cote, John Quackenbush, William T. Barry, Yaoyu E. Wang, Edwin Choy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
BackgroundThere is a lack of well validated biomarkers in osteosarcoma, a rare, recalcitrant disease with variable outcome and poorly understood biologic behavior, for which treatment standards have stalled for decades. The only standard prognostic f
Autor:
Hanqi Tang, Wen Zhang, Panpan Zhang, Jiuliang Zhao, Hua Chen, Yunyun Fei, Di Wu, Xuan Zhang, Shangzhu Zhang, Huaxia Yang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Linyi Peng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
This prospective cohort study aims to investigate the incidence, related factors and prognosis of IgG4-related disease (IgG4-RD) with malignancies in the Chinese cohort. We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical
Autor:
Àngel Argilés, Vasiliki Lygirou, Eleni Petra, Flore Duranton, Harald Mischak, Manousos Makridakis, Jerome Zoidakis, Szymon Filip, Antonia Vlahou, Georgia Kontostathi, Rafael Stroggilos
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Current diagnostic measures for Chronic Kidney Disease (CKD) include detection of reduced estimated glomerular filtration rate (eGFR) and albuminuria, which have suboptimal accuracies in predicting disease progression. The disease complexity and hete
Autor:
Alan I. So, Ninadh M. D'Costa, Yen-Yi Lin, César Monjarás-Ávila, Davide P. Cinà, Faraz Hach, Christian K. Kollmannsberger, Raunak Shrestha, Robert H. Bell, Claudia Chavez-Munoz, Hossein Asghari
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Clear-cell renal cell carcinoma (ccRCC) is a common therapy resistant disease with aberrant angiogenic and immunosuppressive features. Patients with metastatic disease are treated with targeted therapies based on clinical features: low-risk patients
Autor:
Mustafa Ascha, Jill S. Barnholtz-Sloan, Andrew E Sloan, Jacqueline Wang, Carol Kruchko, Priya Kumthekar
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Bevacizumab is FDA-approved in the treatment of primary brain tumors, but its efficacy in patients with brain metastases could be better-studied. This study examines a population of non-small cell lung cancer (NSCLC) patients with synchronous brain m
Autor:
Luisa F. Escobar-Hoyos, Lucia Roa-Peña, Kenneth R. Shroyer, Chun-Hao Pan, Jela Bandovic, Richard A. Moffitt, Cindy V. Leiton, Elizabeth A. Vanner, Ali Akalin, Sruthi Babu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Although the overall five-year survival of patients with pancreatic ductal adenocarcinoma (PDAC) is dismal, there are survival differences between cases with clinically and pathologically indistinguishable characteristics, suggesting that there are u
Autor:
Laguzzi, Federica, Maitusong, Buamina, Strawbridge, Rona J., Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E., Rauramaa, Rainer, Kurl, Sudhir, Smit, Andries J., Giral, Philippe, Silveira, Angela, Tremoli, Elena, Hamsten, Anders, de Faire, Ulf, Gigante, Bruna, Leander, Karin, Sirtori, C. R., Calabresi, L., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Tedesco, C., Coggi, D., Capra, N., Bonomi, A., Eriksson, P., Cooper, J., Acharya, J., Savonen, K., Huttunen, K., Rauramaa, E., Penttila, I. M., Törrönen, J., van Gessel, A. I., van Roon, A. M., Nicolai, A., Mulder, D. J., Kontush, A., Carrié, A., Gallo, A., Karppi, J., Nurmi, T., Nyyssönen, K., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Sennblad, B., Pirro, M., Vaudo, G., Siepi, D., Lupattelli, G., Mannarino, M. R., Bianconi, V.
Publikováno v:
Scientific Reports, 11(1):7866. Nature Publishing Group
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.7866. ⟨10.1038/s41598-021-86324-w⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.7866. ⟨10.1038/s41598-021-86324-w⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it woul
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The risk of osteoporosis in patients with chronic inflammatory neuropathy (CIN) has not been evaluated in detail. We conducted a population-based case-control study nested in a retrospective cohort to analyze osteoporosis risk among patients with CIN
Autor:
Paul Saftig, Peter Kunach, Randall J. Bateman, Wiesje M. van der Flier, Philip Scheltens, Judes Poirier, John C.S. Breitner, Pedro Rosa-Neto, Mark A. Hancock, Christoph Hock, Vivienne Engelschalt, Filip Liebsch, Adeola Shobo, Charlotte E. Teunissen, Irem Ulku, Gerhard Multhaup, Luka Kulic
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10(1):2240. Nature Publishing Group
Nature Communications
Liebsch, F, Kulic, L, Teunissen, C, Shobo, A, Ulku, I, Engelschalt, V, Hancock, M A, van der Flier, W M, Kunach, P, Rosa-Neto, P, Scheltens, P, Poirier, J, Saftig, P, Bateman, R J, Breitner, J, Hock, C & Multhaup, G 2019, ' Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression ', Nature Communications, vol. 10, no. 1, 2240 . https://doi.org/10.1038/s41467-019-10152-w
Nature Communications, 10(1):2240. Nature Publishing Group
Nature Communications
Liebsch, F, Kulic, L, Teunissen, C, Shobo, A, Ulku, I, Engelschalt, V, Hancock, M A, van der Flier, W M, Kunach, P, Rosa-Neto, P, Scheltens, P, Poirier, J, Saftig, P, Bateman, R J, Breitner, J, Hock, C & Multhaup, G 2019, ' Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression ', Nature Communications, vol. 10, no. 1, 2240 . https://doi.org/10.1038/s41467-019-10152-w
The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the generation of Aβ peptides. Here, we provide evidence that altered BACE1 levels and activity