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Publikováno v:
British Journal of Cancer
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Bisphosphonates are well established in the management of breast-cancer-induced bone disease. Recent studies have suggested that these compounds are effective in preventing the development of bone metastases. However, it is unclear whether this refle
Autor:
Hans Gelderblom, I Camlett, Jaap Verweij, B Hennis, M.E.L. van der Burg, Alex Sparreboom, E Wilms, Walter J. Loos, Marijke A. Mantel, M.J.A. de Jonge
Publikováno v:
British Journal of Cancer
British Journal of Cancer, 85(8), 1124-1129. Nature Publishing Group
British Journal of Cancer, 85(8), 1124-1129. Nature Publishing Group
Both weekly cisplatin chemotherapy and single agent topotecan have proven to be effective in recurrent ovarian cancer. Preclinical data show synergism between cisplatin and topotecan. Side effects for this combination are drug sequence dependent and
Autor:
Jennifer Treleaven, R. L. Powles, Jayesh Mehta, Radovan Saso, Bhawna Sirohi, Clive Horton, Samar Kulkarni, Claudius Rudin, Seema Singhal, A Rigg
Publikováno v:
British Journal of Cancer
We correlated age and body surface area corrected glomerular filtration rate (GFR) at the time of high-dose melphalan (HDM) administration with treatment-related toxicity (TT), time to disease progression and survival. Between 8/85 and 6/98, 144 newl
Autor:
M.D. Peake, P M Hepburn, Julia Brown, K.M. Poulter, E M Gurney, Vicky Napp, Peter Johnson, M.F. Muers
Publikováno v:
British Journal of Cancer
A randomized trial was conducted to determine whether administration of Amifostine with chemotherapy for small cell lung cancer could decrease the toxicity. 84 patients with small cell lung cancer of favourable prognosis (limited disease, performance
Autor:
Hitoshi Kawamata, Fumie Omotehara, Nasima-Mila Begum, Mitsunobu Sato, Daisuke Uchida, Koh-ichi Nakashiro, Takahiro Fujimori, S Hino, Mohammad O. Hoque, Hideo Yoshida
Publikováno v:
British Journal of Cancer
Retinoids inhibit the proliferation of several types of tumour cells, and are used for patients with several malignant tumours. In this study, we examined the effect of retinoic acids (RAs) on the invasive potentials of the oral squamous cell carcino
Autor:
Xavier Pivot, B Laguerre, L. Cals, M. Schneider, L. Kayitalire, V Ripoche, J L Lefebvre, Eric Raymond, D Gedouin, J Latz, M Degardin, J.P. Armand, C. Niyikiza, R Johnson
Publikováno v:
British Journal of Cancer
This phase II study determined response rate of patients with locally advanced or metastatic head and neck cancer treated with pemetrexed disodium, a new multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase and glycina
Publikováno v:
British Journal of Cancer
Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclea
Publikováno v:
British Journal of Cancer
Neuroblastoma, the most common extracranial solid tumour in children, may undergo spontaneous differentiation or regression, but the majority of metastatic neuroblastomas have poor prognosis despite intensive treatment. Retinoic acid regulates growth
Autor:
Tuula Salo, Ulf-Håkan Stenman, Erkki Koivunen, Timo Sorsa, Caj Haglund, Annukka Paju, Torsten Wahlström, Taina Tervahartiala, Arto Leminen
Publikováno v:
British Journal of Cancer
Proteolysis mediated by matrix metalloproteinases (MMPs) and serine proteinases is associated with cancer invasion and metastasis. Activation of latent proMMPs, and especially the proforms of the type IV collagen degrading gelatinases A and B (proMMP
Autor:
R J Sambrook, David J. Girling
Publikováno v:
British Journal of Cancer
Many chemotherapy regimens are used for treating SCLC in the United Kingdom, but it is not known, in any detail, which regimens are used, by which specialists, for which types of patient. We conducted a survey among all medical and clinical oncologis