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Autor:
Yong-Mei Fu, Wei Bi, Xiaofeng Cheng, Shu Xiao, Xin Lan, Hongmei Li, Jiayi Zhao, Daxiang Lu, Wei Wei, Jiawei Zhang, Yanping Wang, Lihong Zhu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and Western blot. We found that LPS t
Cold-inducible RNA-binding Protein Induces Neutrophil Extracellular Traps in the Lungs during Sepsis
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Extracellular cold-inducible RNA-binding protein (CIRP) exaggerates inflammation and tissue injury in sepsis. Neutrophil extracellular traps (NETs) are released by activated neutrophils during sepsis. NETs contribute to pathogen clearance, but excess
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Sepsis, a systemic inflammatory response syndrome caused by infection, is the most common disease in patients treated in intensive care units. Endotoxic shock, the most critical form of sepsis, is caused by gram-negative bacterial infection. However,
Autor:
Valderlane L. P. Colares, Nágila Caroline Fialho Sousa, Cristina de Andrade Monteiro, Mizael Calácio Araújo, Simone A. Teixeira, Suellen Nogueira Linares Lima, Walter L. Siqueira, Eduardo Buozi Moffa, Marcelo Nicolas Muscará, Domingos M. S. Pereira, Saulo J. F. Mendes, Matheus Coelho Bandeca, Elizabeth S. Fernandes
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Hydrogen peroxide (H2O2)-based products are effective in tooth whitening; however, their safety is controversial as they may harm patient tissues/cells. These effects are suggested to be concentration-dependent; nonetheless, to date, there are no rep
Autor:
Subhra K. Biswas, Sajay Bhuvanendran Nair Gourikutty, Yunxiao Liu, Shilpi Gupta, Patthara Kongsuphol, Qasem Ramadan
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Chronic inflammation mediated by the interaction of immune cells and adipocytes is a key underlying factor in obesity-associated type 2 diabetes mellitus (T2DM). Therefore, methods to investigate adipocyte-immune cells interaction and their immuno-me
Autor:
Sung-Gyoo Park, Jung Eun Park, Jung Sup Lee, Kyu-Young Sim, Jeonghwan Gwak, Byeong C. Kim, Kyu Yeong Choi, Woo Keun Song, Sang-Heon Park, Kun Ho Lee
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
The symptoms of Alzheimer’s disease (AD), a major cause of dementia in older adults, are linked directly with neuronal cell death, which is thought to be due to aberrant neuronal inflammation. Autoantibodies formed during neuronal inflammation show
Autor:
Ruey-Hsing Chou, Shing Jong Lin, Chi-Yu Chen, Po Hsun Huang, Chun-Chin Chang, I-Chun Chen, Chin-Sung Kuo, Hsin-Lei Huang, Jaw Wen Chen, Ya Wen Lu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Trimethylamine N-oxide (TMAO) is a metabolite originated from bacterial metabolism of choline-rich foods. Evidence suggests an association between TMAO and atherosclerosis, but the relationship between TMAO and endothelial progenitor cells (EPCs) rem
Autor:
M. B. Perez Lana, M. Pelayo, Patricia Maidana, S. Mallea-Gil, Mónica Rosales, Analy Fritzler, Gonzalez D, E. Lamas Majek, Bibiana Fabre, Viviana Mesch, Y. Mocarbel, K. Sternberg, F. González de Chazal, E. Genovesi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
Scientific Reports
Scientific Reports
Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish
Autor:
Susanne Michen, Andreas Janke, Dietmar Appelhans, Achim Temme, Alexander Hagstotz, Gabriele Schackert, Isabell Schau
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Application of Toll-like receptor (TLR) agonists is a promising approach to treat cancer. In particular, nucleic acid-based TLR agonists such as short ssRNA and dsRNA molecules, which activate endosomal TLRs, can be delivered to tumors by use of nano
Autor:
Anita Krnjic, Rayko Evstatiev, Kristine Jimenez, Maximilian Baumgartner, Christina Gmainer, Adrian Frick, Christoph Gasche, Michaela Lang, Mario Asboth, Vineeta Khare
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Disruption of mucosal structure and barrier function contribute to the pathogenesis of inflammatory bowel disease (IBD). Efficacy of therapy in IBD is based on endoscopic mucosal healing, which occurs by a dynamic interplay of epithelial cell regener