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Autor:
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer
Publikováno v:
Nature Cell Biology, 24(6), 872-884. Nature Publishing Group
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.M
Autor:
Ying-Ying Liang, Fei-Yu Niu, An-An Xu, Li-Li Jiang, Chun-shan Liu, Hui-ping Liang, Yu-Fan Huang, Xun-Fan Shao, Zhi-Wen Mo, Ya-Wei Yuan
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Worldwide, nasopharyngeal carcinoma (NPC) is a rare head and neck cancer; however, it is a common malignancy in southern China. Radiotherapy is the most important treatment strategy for NPC. However, although radiotherapy is a strong tool to kill can
Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice
Autor:
Michelle K. Sercundes, Luana S. Ortolan, Viviane da Silva Julio, Leonardo M. Bella, Thatyane de Castro Quirino, Daniela Debone, Marcela S. Carneiro-Ramos, Marcelo A. Christoffolete, Joilson O. Martins, Maria Regina D’Império Lima, José M. Alvarez, Gustavo P. Amarante-Mendes, Lígia Antunes Gonçalves, Claudio R. F. Marinho, Sabrina Epiphanio
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Malaria is an enormous burden on global health that caused 409,000 deaths in 2019. Severe malaria can manifest in the lungs, an illness known as acute respiratory distress syndrome (ARDS). Not much is known about the development of malaria-associated
Autor:
Danyang Shi, Jinhua Ding, Shouqiang Xie, Lei Huang, Hongmin Zhang, Xiaojie Chen, Xuejun Ren, Sa Zhou, Hongpeng He, Wenjian Ma, Tongcun Zhang, Nan Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Upon vascular injury, vascular smooth muscle cells (VSMCs) change from a contractile phenotype to a synthetic phenotype, thereby leading to atherogenesis and arterial restenosis. Myocardin (MYOCD) is essential for maintaining the contractile phenotyp
Autor:
Maher Albitar, Hong Zhang, Andre Goy, Zijun Y. Xu-Monette, Govind Bhagat, Carlo Visco, Alexandar Tzankov, Xiaosheng Fang, Feng Zhu, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andrés J. M. Ferreri, Michael B. Møller, Benjamin M. Parsons, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Bing Xu, Ken H. Young
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 2, Pp 1-9 (2022)
Blood Cancer Journal, 12
Blood Cancer Journal, 12, 2
Albitar, M, Zhang, H, Goy, A, Xu-Monette, Z Y, Bhagat, G, Visco, C, Tzankov, A, Fang, X, Zhu, F, Dybkaer, K, Chiu, A, Tam, W, Zu, Y, Hsi, E D, Hagemeister, F B, Huh, J, Ponzoni, M, Ferreri, A J M, Møller, M B, Parsons, B M, van Krieken, J H, Piris, M A, Winter, J N, Li, Y, Xu, B & Young, K H 2022, ' Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms ', Blood Cancer Journal, vol. 12, no. 2, 25 . https://doi.org/10.1038/s41408-022-00617-5
Albitar, M, Zhang, H, Goy, A H, Xu-Monette, Z, Bhagat, G, Visco, C, Tzankov, A, Fang, X, Zhu, F, Dybkaer, K, Chiu, A, Tam, W, Zu, Y, Hsi, E D, Hagemeister, F B, Huh, J, Ponzoni, M, Ferreri, A J M, Moller, M, Parsons, B M, Van Krieken, J H J M, Piris, M A, Winter, J N, Li, Y, Xu, B & Young, K H 2021, ' Determining Clinical Course of Diffuse Large B-Cell Lymphoma Using Targeted Transcriptome and Machine Learning Algorithms ', Blood, vol. 138, no. Suppl. 1, 2395 . https://doi.org/10.1182/blood-2021-148841
Blood Cancer Journal
Blood Cancer Journal, 12
Blood Cancer Journal, 12, 2
Albitar, M, Zhang, H, Goy, A, Xu-Monette, Z Y, Bhagat, G, Visco, C, Tzankov, A, Fang, X, Zhu, F, Dybkaer, K, Chiu, A, Tam, W, Zu, Y, Hsi, E D, Hagemeister, F B, Huh, J, Ponzoni, M, Ferreri, A J M, Møller, M B, Parsons, B M, van Krieken, J H, Piris, M A, Winter, J N, Li, Y, Xu, B & Young, K H 2022, ' Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms ', Blood Cancer Journal, vol. 12, no. 2, 25 . https://doi.org/10.1038/s41408-022-00617-5
Albitar, M, Zhang, H, Goy, A H, Xu-Monette, Z, Bhagat, G, Visco, C, Tzankov, A, Fang, X, Zhu, F, Dybkaer, K, Chiu, A, Tam, W, Zu, Y, Hsi, E D, Hagemeister, F B, Huh, J, Ponzoni, M, Ferreri, A J M, Moller, M, Parsons, B M, Van Krieken, J H J M, Piris, M A, Winter, J N, Li, Y, Xu, B & Young, K H 2021, ' Determining Clinical Course of Diffuse Large B-Cell Lymphoma Using Targeted Transcriptome and Machine Learning Algorithms ', Blood, vol. 138, no. Suppl. 1, 2395 . https://doi.org/10.1182/blood-2021-148841
Blood Cancer Journal
Introduction: Multiple studies have demonstrated that diffuse large B-cell lymphoma (DLBCL) can be divided into subgroups based on their biology. However, these biological subgroups overlap clinically. While R-CHOP (rituximab, cyclophosphamide, doxor
Autor:
Yasunari Fukuda, Matias A. Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M. Lopez, Jared K. Burks, Jeffrey E. Lee, Elizabeth A. Grimm, Dave S. B. Hoon, Suhendan Ekmekcioglu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways. Soluble CD74 (sCD74) has been identified in sera of inflammatory diseases and implicated in their pathophysiology; however, few relevant data are available
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-12 (2022)
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library conta
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal inflammatory disease comprising Crohn’s disease and ulcerative colitis, remains unclear. Studies on ubiquitination, which regulates the degradation of inflammati
Autor:
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagné, Pascal Finetti, Katerina Ambrosova, Célia D. Rouault, Arnaud Sergé, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, José Adelaide, Emmanouil Zacharioudakis, Rémy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-15 (2022)
Cell Death and Disease
Cell Death and Disease, 2022, 13 (2), pp.96. ⟨10.1038/s41419-022-04538-w⟩
Cell Death and Disease
Cell Death and Disease, 2022, 13 (2), pp.96. ⟨10.1038/s41419-022-04538-w⟩
Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication. We demonstrated that
Autor:
Zhiling Zhou, Jiaxin Zhan, Qiong Luo, Xinghua Hou, Shuxia Wang, Dingzhang Xiao, Zhi Xie, Haidan Liang, Shuguang Lin, Meng Zheng
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Metastatic tumors are mainly composed of neoplastic cells escaping from the primary tumor and inflammatory cells egressing from bone marrow. Cancer cell and inflammatory cell are remained in the state of immaturity during migration to distant organs.