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Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Innate radioresistance substantially limits the effectiveness of radiotherapy for colorectal cancer (CRC); thus, a strategy to enhance the radiosensitivity of CRC is urgently needed. Herein, we reported that ankyrin repeat and KH domain containing 1
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-14 (2022)
Breast cancer is the most common malignancy among women across the globe. Recent studies have revealed that many long non-coding RNAs (lncRNAs) regulate the Wnt/β-catenin signaling pathway in several types of cancer. Hyperactivation of the Wnt/β-ca
Autor:
Minle Li, Xue Zhao, Hongmei Yong, Jian Xu, Pengfei Qu, Shuxi Qiao, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-12 (2022)
Transketolase (TKT) which is an important metabolic enzyme in the pentose phosphate pathway (PPP) participates in maintaining ribose 5-phosphate levels. TKT is necessary for maintaining cell growth. However, we found that in addition to this, TKT can
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Hepatitis B virus (HBV) infection is the predominant causes of hepatocellular carcinoma (HCC). HBV X protein (HBx), as the most frequently integrated viral gene sequence following HBV infection, plays a critical role in the pathogenesis of HCC. H3K27
Autor:
Sharon J. Manley, Appolinaire A. Olou, Jarrid L. Jack, Mariana T. Ruckert, R. McKinnon Walsh, Austin E. Eades, Bailey A. Bye, Joe Ambrose, Fanuel Messaggio, Shrikant Anant, Michael N. VanSaun
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-10 (2022)
Obesity creates a localized inflammatory reaction in the adipose, altering secretion of adipocyte-derived factors that contribute to pathologies including cancer. We have previously shown that adiponectin inhibits pancreatic cancer by antagonizing le
Autor:
Seung Un Seo, Seon Min Woo, Seung-Soon Im, Younghoon Jang, Eugene Han, Sang Hyun Kim, Hongchan Lee, Hyun-Shik Lee, Ju-Ock Nam, Edward Gabrielson, Kyoung-jin Min, Taeg Kyu Kwon
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Cathepsin D (Cat D) is well known for its roles in metastasis, angiogenesis, proliferation, and carcinogenesis in cancer. Despite Cat D being a promising target in cancer cells, effects and underlying mechanism of its inhibition remain unclear. Here,
Autor:
Kuo-Chung Lan, Kuo-Ting Wei, Pei-Wen Lin, Ching-Chen Lin, Pei-Ling Won, Ya-Fen Liu, Yun-Ju Chen, Bi-Hua Cheng, Tien-Min G. Chu, Jia-Feng Chen, Ko-En Huang, Chawnshang Chang, Hong-Yo Kang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Low testosterone level is an independent predictor of osteoporotic fracture in elderly men as well as increased fracture risk in men undergoing androgen deprivation. Androgens and androgen receptor (AR) actions are essential for bone development and
Autor:
Jianyang Xiang, Wahafu Alafate, Wei Wu, Yichang Wang, Xiaodong Li, Wanfu Xie, Xiaobin Bai, Ruichun Li, Maode Wang, Jia Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Cell Death & Disease
Cell Death & Disease
Glioblastoma (GBM) is one of the most lethal primary brain tumor with a poor median survival less than 15 months. Despite the development of the clinical strategies over the decades, the outcomes for GBM patients remain dismal due to the strong proli
Autor:
Ying Yu, Bing Liu, Xuexiang Li, Dingheng Lu, Likun Yang, Liang Chen, Yunxue Li, Lulin Cheng, Fang Lv, Pu Zhang, Yarong Song, Yifei Xing
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Cell Death & Disease
Cell Death & Disease
The survival of cancer cells after detaching from the extracellular matrix (ECM) is essential for the metastatic cascade. The programmed cell death after detachment is known as anoikis, acting as a metastasis barrier. However, the most aggressive can
Autor:
Zhang, Xiao-Wei, Li, Lin, Hu, Wen-Qian, Hu, Ming-Ning, Tao, Yan, Hu, Hui, Miao, Xiao-Kang, Yang, Wen-Le, Zhu, Qiong, Mou, Ling-Yun
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Cell Death & Disease
Cell Death & Disease
Despite the great advances in target therapy, lung cancer remains the top cause of cancer-related death worldwide. G protein-coupled receptor neurokinin-1 (NK1R) is shown to play multiple roles in various cancers; however, the pathological roles and