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Autor:
H Fiegl, Lourdes Rocamora-Reverte, Walther Parson, Claudia Soratroi, Gerlinde Karbon, Haschka, Hubert Hackl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mitochondri
Autor:
Hongli Li, Ruijun Feng, Chonggao Yin, Yuanhang Zheng, Lihong Shi, Wenhao Wang, Zhimei Sheng, Chong Hao, Qinpei Xiao, Ziqian Yan, Baogang Zhang, Hao Luo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is particularly important. In this study, we com
Autor:
Georg Halder, Nathalie Eysackers, Inge Mannaerts, Stefaan Verhulst, Leo A. van Grunsven, Mina Kazemzadeh Dastjerd, Vincent Merens, Vincent De Smet
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates largely focus on targeti
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
While long noncoding RNAs (lncRNAs) have been reported to play an important role in human cancer types, they remain poorly understood in papillary thyroid carcinoma (PTC). The aim of this study was to use genome-wide expression profiling to identify
Autor:
Giorgio Zauli, Barbara Toffoli, Federica Tonon, Veronica Tisato, Bruno Fabris, Paola Secchiero, Stella Bernardi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
TNF-related apoptosis-inducing ligand (TRAIL) is a protein that induces apoptosis in cancer cells but not in normal ones, where its effects remain to be fully understood. Previous studies have shown that in high-fat diet (HFD)-fed mice, TRAIL treatme
Autor:
Xiaofeng Zou, Quanliang Liu, Guancheng Xiao, Kaiyang Qiu, Yuting Wu, Junrong Zou, Guoxi Zhang, Gengqing Wu, Rihai Xiao, Hui Xu, Biao Qian, Yunfeng Liao, Yanmin Li, Tianpeng Xie, Jinglin Shi, Zhihua He, Yuanhu Yuan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinom
Autor:
Min Zhou, Xiaoyu He, Yiyi Feng, Renbing Jia, Jiayan Fan, Yongyun Li, Xiaofang Xu, Chunyan Zong, Yanping Han, Jie Yang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing o
Autor:
Wen-Jie Luo, Dingwei Ye, Yongqiang Huang, Yuan-Yuan Qu, Wenhao Xu, Mengfei Yao, Jun Wang, Chunguang Ma, Yiping Zhu, Hailiang Zhang, Fangning Wan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and prog
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Autor:
Yuan-Ting Kuo, Kai-Ti Lin, Yi-Hsiang Wang, Wen-Hung Kuo, Chia-Yi Shen, Lu-Hai Wang, Wen-Ching Wang, Yu-Ling Hsu, Sheng-Chieh Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast ca