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Autor:
Lu Liu, Kairong Han, Mingyue Tao, Zhengwei Zhang, Zhen Song, Tong Gu, Weiyong Yu, Xiaofei Chen, Xiaojuan Yu, Li Zhang, Xiujuan Huang, Chao Luo, Hao Gu, Jing Luo, Yali Jun, Qilong Wang, Su’an Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-14 (2021)
Tumor cells require high levels of cholesterol for membrane biogenesis for rapid proliferation during development. Beyond the acquired cholesterol from low-density lipoprotein (LDL) taken up from circulation, tumor cells can also biosynthesize choles
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
The lncRNA ZFAS1 plays a carcinogenic regulatory role in many human tumours, but it is rarely reported in pancreatic cancer. We identify the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in
Autor:
Huan Dou, Jun Liang, Jingman Li, Wei Kong, Li Lu, Yuchen Pan, Jiali Wang, Xiaoyu Xia, Dan Li, Yayi Hou, Tingting Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Recent studies indicate that Toll-like receptors (TLRs) and C-type lectin receptors (CLRs) can function as the signal of pattern recognition receptors, which play a pivotal role in the pathogenesis of the autoimmune disease. Systemic lupus erythemato
Autor:
Zhi Wei, S. Banerjee, Angela De Michele, Erle S. Robertson, Natalie N. C. Shih, Michael Feldman, Thaer Khoury, Dipayan Bose, Tian Tian
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Alterations to the natural microbiome are linked to different diseases, and the presence or absence of specific microbes is directly related to disease outcomes. We performed a comprehensive analysis with unique cohorts of the four subtypes of breast
Autor:
Congcong Zhang, Zhixian Wang, Xin Xu, Lifang Ma, Jiayi Wang, Yongjie Niu, Yongchun Yu, Yan Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Diabetes is an important risk factor for liver cancer, but its mechanism is unknown. Corosolic acid (CA) has been proven to have both hypoglycemic and antitumor effects, so revealing the function of CA can help us understand the relationship between
Autor:
Peijing Zhang, Shan Huang, Yiming Zeng, Manyu Zhao, Hong Luo, Zhicheng Zhou, Yuan Quan, Mengru Ma, Li Su, Lixu Tang, Jongchan Kim
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, h
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two predominant pathways that regulate tumour growth and metastasis. Therefore, we explored the potential crosstalk between these two functionally relevant pathways to co
Autor:
Ji Sun, Cong Zhang, Chunbin Duan, Xueying Wang, Changming An, Zhennan Yuan, Lunhua Guo, Kaibin Song, Hongxue Meng, Erliang Guo, Weiwei Yang, Guohui Wang, Xionghui Mao, Xianguang Yang, Xiaomei Li, Susheng Miao, Xiwei Zhang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anilin actin-binding protein (ANLN) has been reported to be associated with carcinogenesis in multiple tumors. However, the expression pattern and functional effect
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
Neurofibromatosis type 1 (NF1), an autosomal dominant and multisystem disorder, is generally considered to be caused by NF1 inactivation. However, there are also numerous studies showing that Neurofibromatosis type 1-like phenotype can be caused by t
Autor:
Zheng Dong, Jane Ding, Yunhong Zha, Han Fei Ding, Chunhong Yan, Yajie Yu, Ahmet Alptekin, Shunqin Zhu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Metabolic reprogramming is an integral part of the growth-promoting program driven by the MYC family of oncogenes. However, this reprogramming also imposes metabolic dependencies that could be exploited therapeutically. Here we report that the pyrimi