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Autor:
Keting Bao, Jinlian Wei, Jian Li, Renbing Jia, Jie Yang, Jin Zhu, Jiahao Shi, Yongyun Li, Fei Mao, Li Ruoxi, Baoli Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Conjunctival melanoma (CM) is a rare and fatal ocular tumour with poor prognosis. There is an urgent need of effective therapeutic drugs against CM. Here, we reported the discovery of a novel potential therapeutic target for CM. Through phenotypic sc
Autor:
Xuxiu Tao, Jinwu Peng, San Xu, Lifang Yang, Dan Li, Xingzhi Peng, Zhuan Zhou, Liangfang Shen, Kun Zhang, Peijun Zhou
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Studies have indicated that dysfunction of autophagy is involved in the initiation and progression of multiple tumors and their chemoradiotherapy. Epstein–Barr virus (EBV) is a lymphotropic human gamma herpes virus that has been implicated in the p
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Osteosarcoma is the most common primary malignant tumor of bone derived from osteoblasts, which is a noteworthy threat to the health of children and adolescents. In this study, we found that MCM8 has significantly higher expression level in osteosarc
Autor:
Huadong Pei, Yiliang Li, Yingtang Gao, Stephanie S. Liu, Wei Zheng, Huiqiang Wei, Hai Yang, Jing Li, Jing Sun, Mingo M. H. Yung, Annie N.Y. Cheung, Ruiqin Wu, Zhuqing Li, John C. Braisted, Hextan Y.S. Ngan, Wenge Zhu, Yi Zhang, David W. Chan, Peter Nemes
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nucleus and
Autor:
Shaobo Wang, Rongrong Zhao, Hao Xue, Xiaofan Guo, Zijie Gao, Ziwen Pan, Xing Guo, Shouji Zhang, Mingyu Qian, Jian Zhang, Jianye Xu, Gang Li, Wei Qiu, Zihang Chen, Zongpu Zhang, Qindong Guo, Xiao Gao, Ping Zhang, Boyan Li, Yanhua Qi, Shulin Zhao, Huizhi Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Exosomes participate in intercellular communication and glioma microenvironment modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote the generation of the immunosuppressive microenvironment are still unclear. Here, we
Autor:
Jan Jacob Schuringa, Luciana Yamamoto Almeida, Thiago Mantello Bianco, Antonio R. Lucena-Araujo, Pedro L Franca-Neto, Juan L Coelho-Silva, Diego A. Pereira-Martins, Rafael F. O. França, Isabel Weinhäuser, Fabiola Traina, Eduardo Magalhães Rego, Cleide Lucia Silva
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell death & disease, 12(4):371. Nature Publishing Group
Cell Death & Disease
Cell death & disease, 12(4):371. Nature Publishing Group
Cell Death & Disease
Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerted by MLL5 in APL regarding cell prolif
Autor:
Xianhui Ruan, Xiangqian Zheng, Dapeng Li, Ming Gao, Wei Zhang, Jingzhu Zhao, Xiukun Hou, Linfei Hu, Songfeng Wei, Xianle Shi, Jihong Yang, Xi Wei
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Cell Death & Disease
Cell Death & Disease
Papillary thyroid carcinoma (PTC) is one of the most common kinds of endocrine-related cancer and has a heterogeneous prognosis. Metabolic reprogramming is one of the hallmarks of cancers. Aberrant glucose metabolism is associated with malignant biol
Autor:
Peter Varughese, Seth Baligod, Junlone Moy, Jose A Colina, Angela Russo, Joanna E. Burdette, Matthew Dean, Austin A. Czarnecki, Daniel D. Lantvit
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the
Autor:
Baiwen Zhang, Cong Zhou, Yao Tang, Xiaojiao Cheng, Qingli Li, Jianzheng Wang, Fuli Li, Wenhui Zhang, Shuiping Tu, Ting-Lei Huang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Utidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, its activity and mechanism in colorectal ca
Autor:
Shiting Li, Xuesheng Zheng, Xuan Zheng, Bowen Chang, Min Yang, Xueyi Wang, Lin Shen, Xiangyu Wei, Zheng Chen, Hanshuo Zhu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) is a subunit of Complex I of the mitochondrial respiratory chain, which is important in metabolic reprogramming and oxidative stress in multiple cancers. However, the biological