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of 680
pro vyhledávání: ''
Autor:
Aleksandra Sobiborowicz, Dominika Nowis, Paweł Jabłoński, Agnieszka Borowiec, Anna A Marusiak, Alicja Mazan, Monika K. Prelowska, Dawid Mehlich, Adam Gorczyński, Ewa Iżycka-Świeszewska, Michał Łomiak, Łukasz M. Szewczyk, Dagmara Dymerska, Anna Mehlich
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Conventional chemotherapy is still of great utility in oncology and rationally constructing combinations with it remains a top priority. Drug-induced mitochondrial apoptotic priming, measured by dynamic BH3 profiling (DBP), has been shown in multiple
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Chemotherapy remains the primary treatment of advanced solid cancer, including lung cancer. However, as first-line treatment, cisplatin-based therapy is restricted by the frequent development of drug resistance. Increasing data showed that the progra
Autor:
Jiarui Liu, Shuai Ren, Yang Han, Xin Wang, Xiangxiang Zhou, Shunfeng Hu, Juan Yang, Yi Zhao, Yiqing Cai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of chem
Autor:
Changrui Qian, Yaqi Wang, Kaiyan Yang, Tianhao Ren, Hongzhi Li, Jiawei Cao, Yingshuai Lv, Haihua Gu, Jieyi Wang, Yang Wang, Du Wu, Guang Wu, Licai He, Wei Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Although endocrine therapies targeting estrogen receptor α (ERα) are effective in managing ER positive (+) breast cancer, many patients have primary resistance or develop resistance to endocrine therapies. In addition, ER+ breast cancer with PIK3CA
Autor:
Angang Yang, Baile Zuo, Wenjin Xi, Rui Zhang, Wei-Hong Wen, Zhangyan Guo, Lin-Tao Jia, Weimiao Li, Guoxu Zheng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Despite the successful use of the humanized monoclonal antibody trastuzumab (Herceptin) in the clinical treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, the frequently occurring drug resistance remains to be
Autor:
Junjie Xu, Liye Tao, Zhongjie Lin, Shunjie Xia, Yifan Wang, Xiao Liang, Liuxin Cai, Zhe Wan, Junhao Zheng, Xiujun Cai, Lin Ji, Yeling Ruan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. The first targeted therapy, sorafenib, prolonged the overall survival by months. However, resistance often occurs, largely limits its
Autor:
Eirini P. Papapetrou, Oliver Soehnlein, Andriana G. Kotini, Ying Wei, Ross L. Levine, David G. Thomas, Marit Westerterp, Joachim Pircher, Hans-Willem Snoeck, Steffen Massberg, Alan R. Tall, Larry Luchsinger, Nan Wang, Chenyi Xue, Carlos Silvestre-Roig, Tong Xiao, M. Yalcinkaya, Trevor P. Fidler, Peter Libby, Christian Schulz, Mohammad Ali Hajebrahimi, Brian Hardaway, Wenli Liu, Muredach P. Reilly, Benjamin L. Ebert, Sandra Abramowicz
Publikováno v:
The journal of cardiovascular aging
Nature, 592(7853), 296-301. Nature Publishing Group
Nature
Nature, 592(7853), 296-301. Nature Publishing Group
Nature
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and stroke independen
Autor:
Keting Bao, Jinlian Wei, Jian Li, Renbing Jia, Jie Yang, Jin Zhu, Jiahao Shi, Yongyun Li, Fei Mao, Li Ruoxi, Baoli Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Conjunctival melanoma (CM) is a rare and fatal ocular tumour with poor prognosis. There is an urgent need of effective therapeutic drugs against CM. Here, we reported the discovery of a novel potential therapeutic target for CM. Through phenotypic sc