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Autor:
Jing Jing Zhao, Yulong Han, Hao Chen, Tong Xiang, De-Sheng Weng, Jian-Chuan Xia, Feng-Ze Sun, Qijing Wang, Yan Tang, Ruiqing Peng, Yuanyuan Chen, Yuan-Yuan Liu, Jia He, Han Li, Yongqiang Li, Chaopin Yang, J. Yang, Mengjia Song, Yue Huang, Qiu-Zhong Pan, Tingting Gong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
Most patients with hepatocellular carcinoma (HCC) are in the middle or advanced stage at the time of diagnosis, and the therapeutic effect is limited. Therefore, this study aimed to verify whether deoxythymidylate kinase (DTYMK) increased in HCC and
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
While long noncoding RNAs (lncRNAs) have been reported to play an important role in human cancer types, they remain poorly understood in papillary thyroid carcinoma (PTC). The aim of this study was to use genome-wide expression profiling to identify
Autor:
Xiaofeng Zou, Quanliang Liu, Guancheng Xiao, Kaiyang Qiu, Yuting Wu, Junrong Zou, Guoxi Zhang, Gengqing Wu, Rihai Xiao, Hui Xu, Biao Qian, Yunfeng Liao, Yanmin Li, Tianpeng Xie, Jinglin Shi, Zhihua He, Yuanhu Yuan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinom
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Mounting studies have substantiated that abrogating autophagy contributes to cardiac hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported to support autophagy and inhibit CH. However, the upstream regulation mechanism behind the regulation of SIRT1
Autor:
Wen-Jie Luo, Dingwei Ye, Yongqiang Huang, Yuan-Yuan Qu, Wenhao Xu, Mengfei Yao, Jun Wang, Chunguang Ma, Yiping Zhu, Hailiang Zhang, Fangning Wan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and prog
Autor:
Jun Zhang, Li Hou, Xiao Yu, Huan Zhang, Qingqing Zhang, Fei Ling, Yunliang Sun, Jinyi Meng, He Huang, Jaceline Gislaine Pires Sanches, Bo Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and metastasis is the major cause of the high mortality of HCC. In this study, we identified that AnnexinA7 (ANXA7) and Sorcin (SRI) are overexpressed and interacting protein
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Colorectal tumorigenesis is a heterogeneous disease driven by multiple genetic and epigenetic alterations. F-box and WD repeat domain containing 11 (FBXW11) is a member of the F-box protein family that regulates the ubiquitination of key factors asso
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two predominant pathways that regulate tumour growth and metastasis. Therefore, we explored the potential crosstalk between these two functionally relevant pathways to co
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Lung squamous cell carcinoma (LUSC) has a poor clinical prognosis and lacks effective targeted therapy. The transmembrane emp24 trafficking protein 3 (TMED3) belongs to the TMED family, which is responsible for the transport of intracellular proteins
Autor:
Yafeng Jiang, Guangsen Zhang, Yujiao Luo, Hongling Peng, Shangjie Wu, Piao Hu, Yewei Wang, Doudou Tang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Uncontrolled proliferation is the hallmark of cancer cells. Previous studies mainly focused on the role of protein-coding genes in cancer cell proliferation. Emerging evidence showed that long non-coding RNAs (lncRNAs) also play critical roles in can