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pro vyhledávání: ''
Autor:
Xianhui Ruan, Xiangqian Zheng, Dapeng Li, Ming Gao, Wei Zhang, Jingzhu Zhao, Xiukun Hou, Linfei Hu, Songfeng Wei, Xianle Shi, Jihong Yang, Xi Wei
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Cell Death & Disease
Cell Death & Disease
Papillary thyroid carcinoma (PTC) is one of the most common kinds of endocrine-related cancer and has a heterogeneous prognosis. Metabolic reprogramming is one of the hallmarks of cancers. Aberrant glucose metabolism is associated with malignant biol
Autor:
Peter Varughese, Seth Baligod, Junlone Moy, Jose A Colina, Angela Russo, Joanna E. Burdette, Matthew Dean, Austin A. Czarnecki, Daniel D. Lantvit
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selective killing of cancer cells underlines its anticancer potential. However, poor tolerability and resistance underscores the need to identify cancer-selective TRAIL-sensitizing agent
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent report
Autor:
Jian Sun, Zhang-Fu Yang, Shuang-Jian Qiu, Yong Yi, Cheng Zhou, Ruo-Yu Guan, Gao Liu, Bao-Ye Sun, Pei-Yun Zhou, Jian Zhou, Jia Fan, Zhu-Tao Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-19 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix (ECM)-producing myofibroblasts, a phenotypes with multiple roles in hepatic fibrogenesis and carcinogenesis via crosstalk with cohabitating stromal/cancer cells
Autor:
Lan Zhou, Jiaqi Wang, Fucun Xie, Lin Wang, Yongsheng Huang, Meng Nie, Hongyang Quan, Yeqing Dong, Jiang Ji, Qianqian Fan, Zhi Zheng, Chuang Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
p97/VCP, an evolutionarily concerned ATPase, partakes in multiple cellular proteostatic processes, including the endoplasmic reticulum (ER)-associated protein degradation (ERAD). Elevated expression of p97 is common in many cancers and is often assoc
Autor:
Xuelei Ruan, Yixue Xue, Lianqi Shao, Di Wang, Xiaobai Liu, Yunhui Liu, Qianshuo Liu, Chunqing Yang, Sifei Yu, Lu Zhu, Fangfang Zhang, Yang Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)
Cell Death & Disease
Cell Death & Disease
Studies have found that RNA-binding proteins (RBPs) are dysfunctional and play a significant regulatory role in the development of glioma. Based on The Cancer Genome Atlas database and the previous studies, we selected heterogeneous nuclear ribonucle
Autor:
Liang Zhu, Jianjia Ma, Weiqin Lu, Yawei Bi, Eunice Kim, Catherine K. Luo, Dan Wang, Vincent W. Yang, Juntao Ji, Guoqiang Wang, Xiaokun Li, James L. Abbruzzese, Zhao-Shen Li, Haojie Huang, Lianghao Hu, Muyun Liu, Yongde Luo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Oncogenic RAS is a critical driver for the initiation and progression of several types of cancers. However, effective therapeutic strategies by targeting RAS, in particular RASG12D and RASG12V, and associated downstream pathways have been so far unsu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
ABIN-1, also called TNIP1, is an ubiquitin-binding protein that serves an important role in suppressing RIPK1-independent apoptosis, necroptosis, and NF-κB activation. However, the involvement of ABIN-1 in the regulation of RIPK1-dependent apoptosis