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Autor:
H Fiegl, Lourdes Rocamora-Reverte, Walther Parson, Claudia Soratroi, Gerlinde Karbon, Haschka, Hubert Hackl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mitochondri
Autor:
Jing Zhao, Han Xiao, Ping Liang, Ning Jiang, Li Zhang, Shuyue Zheng, Hui Gan, Xuan Zhai, Hui Chen, Lu Wang
Publikováno v:
Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1807-1818 (2021)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The NLRC4 inflammasome, a member of the nucleotide-binding and oligomerization domain-like receptor (NLR) family, amplifies inflammation by facilitating the processing of caspase-1, interleukin (IL)–1β, and IL-18. We explored whether NLRC4 knockdo
Autor:
Sara Hultberg, Kurt Wahlstedt, Margareta Reis, Jörgen Rosén, Kristoffer N.T. Månsson, Olof R. Hjorth, Malin Gingnell, Vanda Faria, Andreas Frick, Johanna M. Hoppe, Mark Lubberink, Mats Fredrikson, Iman Alaie, Tomas Furmark, Gunnar Antoni, My Jonasson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with serotonin transporte
Autor:
Yifang Liu, Jiaojiao Yang, Li Luo, Wei Wu, Kaijing Zhong, Jiyao Li, Mingyue Han, Lizhong Sun, Shijie Shi, Libang He
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-14 (2021)
International Journal of Oral Science
International Journal of Oral Science
Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflamm
Autor:
Jean-Michel Hartmann, Nicolas Pauc, Emilie Sakat, Frederic Boeuf, Jérémie Chrétien, Julien Chaste, Vincent Calvo, Alexei Chelnokov, Moustafa El Kurdi, Marvin Frauenrath, Vincent Reboud, Maksym Gromovyi, Andjelika Bjelajac, Binbin Wang, Gilles Patriarche, Etienne Herth, Philippe Boucaud
Publikováno v:
Light: Science & Applications, Vol 10, Iss 1, Pp 1-13 (2021)
Light: Science and Applications
Light: Science and Applications, Nature Publishing Group, 2021, 10, ⟨10.1038/s41377-021-00675-7⟩
Light, Science & Applications
Light: Science and Applications, 2021, 10, ⟨10.1038/s41377-021-00675-7⟩
Light: Science and Applications
Light: Science and Applications, Nature Publishing Group, 2021, 10, ⟨10.1038/s41377-021-00675-7⟩
Light, Science & Applications
Light: Science and Applications, 2021, 10, ⟨10.1038/s41377-021-00675-7⟩
GeSn alloys are promising materials for CMOS-compatible mid-infrared lasers manufacturing. Indeed, Sn alloying and tensile strain can transform them into direct bandgap semiconductors. This growing laser technology however suffers from a number of li
Autor:
Zhonghua Zhao, Huijuan Wu, Jinfang Bao, Jun Liu, Yili Fang, Nan Zhu, Chenyang Qi, Zhihuang Zheng, Chuanlei Li, Kexin Xu, Qing Yu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Nod-like receptor protein 3 (NLRP3), as an inflammatory regulator, has been implicated in acute kidney injury (AKI). Failed recovery after AKI can lead to chronic kidney disease (CKD). However, the role of NLRP3 in the AKI-CKD transition is still unk
Autor:
Yiwei Huang, Guoshu Bi, Zhencong Chen, Zongwei Chen, Lijie Tan, Yuansheng Zheng, Zhengyang Hu, Qun Wang, Weigang Guo, Zongwu Lin, Yunyi Bian, Mengnan Zhao, Cheng Zhan, Yanrui Pang
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-13 (2021)
Oncogenesis
Oncogenesis
Esophageal squamous cell carcinoma (ESCC) accounts for 90% of all cases of esophageal cancers worldwide. Although neoadjuvant chemotherapy (NACT-ESCC) improves the survival of ESCC patients, the five-year survival rate of these patients is dismal. Th
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-7 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
This study (ORIENT-4) aimed to assess the efficacy and safety of sintilimab, a humanized anti-PD-1 antibody, in patients with relapsed/refractory extranodal NK/T cell lymphoma (r/r ENKTL). ORIENT-4 is a multicenter, single-arm, phase 2 clinical trial
Autor:
Fei Zhang, Lei Wang, Yanglin Yan, Jian Zhang, Tao Wang, Hong Luo, Wuxun Peng, Zhihong Xie, Wentao Dong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Novel therapies for the treatment of early steroid-induced osteonecrosis of the femoral head (SONFH) are urgently needed in orthopedics. Transplantation of bone marrow mesenchymal stem cells (BMSCs) provides new strategies for treating this condition
Autor:
Kelly K Noah, Geeta Sarphare, Elaine Tierney, Forbes D. Porter, Audrey Thurm, Irena Bukelis, Christopher A. Wassif, Joan E. Bailey-Wilson, Lisa E. Kratz, Leah Jager, Alan T. Remaley, Eun Sol Jung, Boudewien Brand
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with